| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 51684 |
Name | SUFU |
Synonymous | suppressor of fused homolog (Drosophila);SUFU;suppressor of fused homolog (Drosophila) |
Definition | suppressor of fused homolog |
Position | 10q24.32 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.23. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.1396G>A; p.E466K; 10:102630096-102630096 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.984C>A; p.N328K; 10:102599506-102599506 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - Missense |
c.984C>A; p.N328K; 10:102599506-102599506 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.1091G>A; p.R364Q; 10:102615336-102615336 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.742G>A; p.D248N; 10:102594051-102594051 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.317+2T>C; p.?; 10:102509305-102509305 |
large_intestine; colon | carcinoma; adenocarcinoma | Unknown |
c.96G>T; p.P32P; 10:102504248-102504248 |
prostate | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1368C>G; p.F456L; 10:102630068-102630068 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.591C>T; p.F197F; 10:102592718-102592718 |
skin; face | carcinoma; basal_cell_carcinoma | Substitution - coding silent |
c.1129_1135delTCCGGAG; p.S377fs*7; 10:102615374-102615380 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma; desmoplastic | Deletion - Frameshift |
c.1088C>T; p.T363M; 10:102615333-102615333 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.433G>A; p.A145T; 10:102550085-102550085 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.598-1G>C; p.?; 10:102593635-102593635 |
lung | carcinoma; squamous_cell_carcinoma | Unknown |
c.1157+1G>A; p.?; 10:102615403-102615403 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma | Unknown |
c.1136C>T; p.A379V; 10:102615381-102615381 |
skin | malignant_melanoma | Substitution - Missense |
c.436C>T; p.R146*; 10:102550088-102550088 |
oesophagus; lower_third | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.741C>T; p.I247I; 10:102594050-102594050 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1069C>T; p.P357S; 10:102615314-102615314 |
skin | malignant_melanoma | Substitution - Missense |
c.1366-1G>A; p.?; 10:102630065-102630065 |
stomach | carcinoma; adenocarcinoma | Unknown |
c.1309G>A; p.E437K; 10:102627187-102627187 |
breast | carcinoma | Substitution - Missense |
c.94C>T; p.P32S; 10:102504246-102504246 |
skin | malignant_melanoma | Substitution - Missense |
c.315T>C; p.H105H; 10:102509301-102509301 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.423G>A; p.M141I; 10:102550075-102550075 |
kidney | other; neoplasm | Substitution - Missense |
c.442_448delGTGTTCC; p.V148fs*30; 10:102550094-102550100 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma; medullomyoblastoma | Deletion - Frameshift |
c.442_448delGTGTTCC; p.V148fs*30; 10:102550094-102550100 |
central_nervous_system; cerebellum | primitive_neuroectodermal_tumour-medulloblastoma; SHH_subtype | Deletion - Frameshift |
c.1123C>T; p.Q375*; 10:102615368-102615368 |
bone; pelvis | chondrosarcoma | Substitution - Nonsense |
c.395C>G; p.A132G; 10:102550047-102550047 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.279C>T; p.F93F; 10:102509265-102509265 |
skin | malignant_melanoma | Substitution - coding silent |
c.1105G>A; p.V369I; 10:102615350-102615350 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1085G>A; p.R362H; 10:102615330-102615330 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1085G>A; p.R362H; 10:102615330-102615330 |
skin | malignant_melanoma | Substitution - Missense |
c.1445C>T; p.P482L; 10:102630145-102630145 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.541G>C; p.E181Q; 10:102592668-102592668 |
biliary_tract; gallbladder | carcinoma; adenocarcinoma | Substitution - Missense |
c.541G>C; p.E181Q; 10:102592668-102592668 |
biliary_tract; gallbladder | carcinoma; adenocarcinoma | Substitution - Missense |
c.635A>G; p.Q212R; 10:102593673-102593673 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.635A>G; p.Q212R; 10:102593673-102593673 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.442G>A; p.V148M; 10:102550094-102550094 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.123C>T; p.C41C; 10:102504275-102504275 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1158-3C>T; p.?; 10:102617287-102617287 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Unknown |
c.1004T>G; p.L335R; 10:102599526-102599526 |
pancreas | carcinoma | Substitution - Missense |
c.1299T>C; p.I433I; 10:102627177-102627177 |
biliary_tract; gallbladder | carcinoma; adenocarcinoma | Substitution - coding silent |
c.671G>A; p.R224Q; 10:102593709-102593709 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.64_65insC; p.A25fs*23; 10:102504216-102504217 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.778_779insAGGGA; p.T261fs*8; 10:102597161-102597162 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma; medullomyoblastoma | Insertion - Frameshift |
c.778_779insAGGGA; p.T261fs*8; 10:102597161-102597162 |
central_nervous_system; cerebellum | primitive_neuroectodermal_tumour-medulloblastoma; SHH_subtype | Insertion - Frameshift |
c.756+1G>T; p.?; 10:102594066-102594066 |
central_nervous_system; brain | glioma | Unknown |
c.1177C>T; p.R393W; 10:102617309-102617309 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.881_882insG; p.T295fs*56; 10:102597264-102597265 |
salivary_gland; maxilla | carcinoma; adenoid_cystic_carcinoma | Insertion - Frameshift |
c.1437C>T; p.F479F; 10:102630137-102630137 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.561C>A; p.P187P; 10:102592688-102592688 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - coding silent |
c.170T>A; p.I57N; 10:102504322-102504322 |
oesophagus | carcinoma | Substitution - Missense |
c.367C>T; p.R123C; 10:102550019-102550019 |
skin | malignant_melanoma | Substitution - Missense |
c.560C>T; p.P187L; 10:102592687-102592687 |
skin; face | carcinoma; basal_cell_carcinoma | Substitution - Missense |
c.1241A>G; p.E414G; 10:102617373-102617373 |
prostate | carcinoma | Substitution - Missense |
c.600C>T; p.I200I; 10:102593638-102593638 |
bone | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - coding silent |
c.850G>T; p.D284Y; 10:102597233-102597233 |
lung; right_lower_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.881G>A; p.G294D; 10:102597264-102597264 |
skin | malignant_melanoma | Substitution - Missense |
c.897A>G; p.R299R; 10:102597280-102597280 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - coding silent |
c.881G>A; p.G294D; 10:102597264-102597264 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.1023-2A>G; p.?; 10:102615266-102615266 |
urinary_tract; bladder | carcinoma | Unknown |
c.896G>A; p.R299Q; 10:102597279-102597279 |
breast | carcinoma; HER-positive_carcinoma | Substitution - Missense |
c.217A>G; p.M73V; 10:102509203-102509203 |
pancreas | carcinoma | Substitution - Missense |
c.217A>G; p.M73V; 10:102509203-102509203 |
pancreas | carcinoid-endocrine_tumour | Substitution - Missense |
c.1022+1G>A; p.?; 10:102599545-102599545 |
oesophagus | carcinoma | Unknown |
c.1022+1G>A; p.?; 10:102599545-102599545 |
large_intestine; colon | carcinoma; adenocarcinoma | Unknown |
c.1022+1G>A; p.?; 10:102599545-102599545 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma; desmoplastic | Unknown |
c.1022+1G>A; p.?; 10:102599545-102599545 |
endometrium | carcinoma; endometrioid_carcinoma | Unknown |
c.135C>T; p.Y45Y; 10:102504287-102504287 |
skin | malignant_melanoma | Substitution - coding silent |
c.1429G>C; p.V477L; 10:102630129-102630129 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.220T>C; p.Y74H; 10:102509206-102509206 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.847G>A; p.E283K; 10:102597230-102597230 |
breast | carcinoma | Substitution - Missense |
c.191G>T; p.G64V; 10:102509177-102509177 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.622C>A; p.L208I; 10:102593660-102593660 |
kidney | carcinoma; papillary_renal_cell_carcinoma | Substitution - Missense |
c.1005C>T; p.L335L; 10:102599527-102599527 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.429C>T; p.G143G; 10:102550081-102550081 |
thyroid | carcinoma | Substitution - coding silent |
c.1221G>A; p.T407T; 10:102617353-102617353 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1233G>T; p.T411T; 10:102617365-102617365 |
prostate | carcinoma; adenocarcinoma | Substitution - coding silent |
c.778G>A; p.E260K; 10:102597161-102597161 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.660G>A; p.L220L; 10:102593698-102593698 |
thyroid | carcinoma | Substitution - coding silent |
c.486C>A; p.S162S; 10:102592613-102592613 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1232C>T; p.T411M; 10:102617364-102617364 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1232C>T; p.T411M; 10:102617364-102617364 |
pleura | mesothelioma | Substitution - Missense |
c.1265A>G; p.H422R; 10:102617397-102617397 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.716G>A; p.R239Q; 10:102594025-102594025 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.221A>G; p.Y74C; 10:102509207-102509207 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1174G>T; p.G392*; 10:102617306-102617306 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.1016G>C; p.R339P; 10:102599538-102599538 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.736G>C; p.E246Q; 10:102594045-102594045 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - Missense |
c.736G>C; p.E246Q; 10:102594045-102594045 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.846C>T; p.P282P; 10:102597229-102597229 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1022C>T; p.P341L; 10:102599544-102599544 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1084C>T; p.R362C; 10:102615329-102615329 |
central_nervous_system; cerebellum | primitive_neuroectodermal_tumour-medulloblastoma; large_cell | Substitution - Missense |
c.634C>T; p.Q212*; 10:102593672-102593672 |
thyroid | carcinoma | Substitution - Nonsense |
c.63T>A; p.T21T; 10:102504215-102504215 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - coding silent |
c.305_306delAC; p.N102fs*4; 10:102509291-102509292 |
pleura | pulmonary_blastoma | Deletion - Frameshift |