Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5320

Name

PLA2G2A

Synonymous

phospholipase A2, group IIA (platelets, synovial fluid);PLA2G2A;phospholipase A2, group IIA (platelets, synovial fluid)

Definition

GIIC sPLA2|NPS-PLA2|group IIA phospholipase A2|non-pancreatic secretory phospholipase A2|phosphatidylcholine 2-acylhydrolase 2A|phospholipase A2, membrane associated

Position

1p35

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.55C>T; p.H19Y; 1:19978510-19978510

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.55C>T; p.H19Y; 1:19978510-19978510

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.101G>A; p.G34E; 1:19978464-19978464

 skinmalignant_melanomaSubstitution - Missense

c.385T>C; p.Y129H; 1:19975751-19975751

 livercarcinomaSubstitution - Missense

c.385T>C; p.Y129H; 1:19975751-19975751

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.112G>A; p.A38T; 1:19978453-19978453

 livercarcinomaSubstitution - Missense

c.148G>A; p.V50M; 1:19978417-19978417

 skinmalignant_melanomaSubstitution - Missense

c.153T>G; p.G51G; 1:19978412-19978412

 thyroidother; neoplasmSubstitution - coding silent

c.138C>T; p.C46C; 1:19978427-19978427

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.34A>T; p.I12F; 1:19978740-19978740

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.118A>G; p.S40G; 1:19978447-19978447

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.374A>G; p.Y125C; 1:19975762-19975762

 thyroidcarcinomaSubstitution - Missense

c.229C>T; p.R77C; 1:19978078-19978078

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.23C>T; p.A8V; 1:19978751-19978751

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.190T>C; p.C64R; 1:19978117-19978117

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.132C>T; p.Y44Y; 1:19978433-19978433

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.132C>T; p.Y44Y; 1:19978433-19978433

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastoma; large_cellSubstitution - coding silent

c.395A>G; p.Y132C; 1:19975741-19975741

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.184C>T; p.R62C; 1:19978381-19978381

 skinmalignant_melanomaSubstitution - Missense

c.90G>C; p.K30N; 1:19978475-19978475

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.373T>A; p.Y125N; 1:19975763-19975763

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.311G>A; p.R104K; 1:19975825-19975825

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.421A>C; p.T141P; 1:19975715-19975715

 breastcarcinomaSubstitution - Missense

c.187T>A; p.C63S; 1:19978120-19978120

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.272C>T; p.S91L; 1:19978035-19978035

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.327G>T; p.E109D; 1:19975809-19975809

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.290G>T; p.C97F; 1:19978017-19978017

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.413G>A; p.R138K; 1:19975723-19975723

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.279C>T; p.S93S; 1:19978028-19978028

 pancreascarcinoma; ductal_carcinomaSubstitution - coding silent

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