Entrez Gene

Basic Information
Gene ID	5331
Name	PLCB3
Synonymous	phospholipase C, beta 3 (phosphatidylinositol-specific);PLCB3;phospholipase C, beta 3 (phosphatidylinositol-specific)
Definition	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3\|PLC beta 3\|PLC-beta-3\|phosphoinositide phospholipase C-beta-3
Position	11q13
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.14.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1161G>A; p.V387V; 11:64258621-64258621	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.227G>A; p.R76Q; 11:64254797-64254797	breast	carcinoma	Substitution - Missense
c.1133C>T; p.T378I; 11:64258593-64258593	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1913+4T>A; p.?; 11:64261669-64261669	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.1369C>T; p.Q457*; 11:64259088-64259088	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.781G>A; p.E261K; 11:64256458-64256458	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1288C>T; p.R430C; 11:64258919-64258919	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2269G>A; p.D757N; 11:64262722-64262722	breast	carcinoma	Substitution - Missense
c.366C>T; p.A122A; 11:64255017-64255017	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.366C>T; p.A122A; 11:64255017-64255017	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.711C>A; p.G237G; 11:64256388-64256388	thyroid	other; neoplasm	Substitution - coding silent
c.1763A>T; p.E588V; 11:64261431-64261431	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.978C>A; p.Y326*; 11:64256730-64256730	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1212G>A; p.S404S; 11:64258672-64258672	thyroid	other; neoplasm	Substitution - coding silent
c.2454C>T; p.S818S; 11:64263596-64263596	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1711delA; p.K572fs*13; 11:64260214-64260214	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.113G>T; p.R38L; 11:64254428-64254428	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2160G>A; p.V720V; 11:64262528-64262528	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2947C>T; p.R983W; 11:64265414-64265414	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1278T>G; p.A426A; 11:64258909-64258909	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1266G>T; p.Q422H; 11:64258897-64258897	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1278T>G; p.A426A; 11:64258909-64258909	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1140C>T; p.G380G; 11:64258600-64258600	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.606C>T; p.S202S; 11:64255729-64255729	skin	malignant_melanoma	Substitution - coding silent
c.3588G>A; p.P1196P; 11:64267439-64267439	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3606G>A; p.G1202G; 11:64267457-64267457	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3606G>A; p.G1202G; 11:64267457-64267457	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2058C>T; p.N686N; 11:64262426-64262426	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2058C>T; p.N686N; 11:64262426-64262426	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3543G>A; p.A1181A; 11:64267394-64267394	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.3071G>A; p.G1024E; 11:64265921-64265921	pancreas	NS	Substitution - Missense
c.2401G>T; p.E801*; 11:64263543-64263543	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - Nonsense
c.2065G>A; p.V689I; 11:64262433-64262433	pancreas	carcinoma	Substitution - Missense
c.3365C>G; p.T1122R; 11:64266503-64266503	urinary_tract; bladder	carcinoma	Substitution - Missense
c.314C>T; p.T105M; 11:64254965-64254965	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.298G>T; p.E100*; 11:64254949-64254949	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.314C>T; p.T105M; 11:64254965-64254965	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.140C>A; p.P47H; 11:64254455-64254455	urinary_tract; bladder	carcinoma	Substitution - Missense
c.127C>T; p.L43L; 11:64254442-64254442	skin	malignant_melanoma	Substitution - coding silent
c.1232C>T; p.S411F; 11:64258692-64258692	skin	malignant_melanoma	Substitution - Missense
c.673G>A; p.D225N; 11:64255796-64255796	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1232C>T; p.S411F; 11:64258692-64258692	skin	malignant_melanoma	Substitution - Missense
c.1232C>T; p.S411F; 11:64258692-64258692	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.474G>A; p.T158T; 11:64255402-64255402	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2022C>T; p.L674L; 11:64262060-64262060	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.159C>G; p.Y53*; 11:64254474-64254474	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3466C>T; p.Q1156*; 11:64267236-64267236	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Nonsense
c.1845C>T; p.F615F; 11:64261597-64261597	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1845C>T; p.F615F; 11:64261597-64261597	breast	carcinoma	Substitution - coding silent
c.1356C>T; p.P452P; 11:64259075-64259075	NS	malignant_melanoma	Substitution - coding silent
c.1356C>T; p.P452P; 11:64259075-64259075	NS	malignant_melanoma	Substitution - coding silent
c.765C>T; p.R255R; 11:64256442-64256442	prostate	carcinoma	Substitution - coding silent
c.1610C>G; p.S537C; 11:64260113-64260113	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.667C>T; p.R223W; 11:64255790-64255790	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1092C>T; p.D364D; 11:64258552-64258552	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2302C>T; p.Q768*; 11:64262755-64262755	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.2302C>T; p.Q768*; 11:64262755-64262755	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2481C>T; p.N827N; 11:64263716-64263716	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2335G>T; p.E779*; 11:64262788-64262788	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Nonsense
c.1211C>T; p.S404L; 11:64258671-64258671	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1958G>A; p.R653H; 11:64261996-64261996	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.830A>G; p.E277G; 11:64256507-64256507	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3057G>T; p.E1019D; 11:64265907-64265907	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2061G>A; p.A687A; 11:64262429-64262429	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.3185G>T; p.R1062I; 11:64266035-64266035	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2568G>A; p.A856A; 11:64264028-64264028	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - coding silent
c.2349C>T; p.F783F; 11:64262802-64262802	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2955A>G; p.A985A; 11:64265422-64265422	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2459A>T; p.Y820F; 11:64263694-64263694	liver	carcinoma	Substitution - Missense
c.2459A>T; p.Y820F; 11:64263694-64263694	liver	carcinoma	Substitution - Missense
c.1227C>T; p.I409I; 11:64258687-64258687	skin	malignant_melanoma	Substitution - coding silent
c.891C>T; p.S297S; 11:64256643-64256643	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.585C>T; p.L195L; 11:64255604-64255604	skin	malignant_melanoma	Substitution - coding silent
c.2149G>A; p.E717K; 11:64262517-64262517	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2535G>C; p.S845S; 11:64263770-64263770	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.2083C>T; p.R695C; 11:64262451-64262451	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1826G>A; p.R609Q; 11:64261494-64261494	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2339_2340CC>TT; p.P780L; 11:64262792-64262793	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2852C>T; p.P951L; 11:64265319-64265319	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2083C>T; p.R695C; 11:64262451-64262451	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2280C>T; p.R760R; 11:64262733-64262733	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2725A>C; p.T909P; 11:64265023-64265023	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2725A>C; p.T909P; 11:64265023-64265023	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.598-9G>T; p.?; 11:64255712-64255712	pancreas	carcinoma	Unknown
c.3387C>T; p.I1129I; 11:64266525-64266525	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.818G>A; p.R273Q; 11:64256495-64256495	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.3387C>T; p.I1129I; 11:64266525-64266525	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2217C>T; p.S739S; 11:64262670-64262670	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2217C>T; p.S739S; 11:64262670-64262670	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2275C>T; p.R759W; 11:64262728-64262728	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2275C>T; p.R759W; 11:64262728-64262728	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2275C>T; p.R759W; 11:64262728-64262728	large_intestine; colon	carcinoma	Substitution - Missense
c.2275C>T; p.R759W; 11:64262728-64262728	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.922C>T; p.L308L; 11:64256674-64256674	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1494C>T; p.S498S; 11:64259213-64259213	breast	carcinoma	Substitution - coding silent
c.1494C>T; p.S498S; 11:64259213-64259213	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1494C>T; p.S498S; 11:64259213-64259213	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1494C>T; p.S498S; 11:64259213-64259213	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3252A>T; p.K1084N; 11:64266188-64266188	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1494C>T; p.S498S; 11:64259213-64259213	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1494C>T; p.S498S; 11:64259213-64259213	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1494C>T; p.S498S; 11:64259213-64259213	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1494C>T; p.S498S; 11:64259213-64259213	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.896A>G; p.Y299C; 11:64256648-64256648	skin	malignant_melanoma	Substitution - Missense
c.1932C>T; p.L644L; 11:64261970-64261970	skin	malignant_melanoma	Substitution - coding silent
c.2804C>T; p.P935L; 11:64265102-64265102	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3214G>A; p.V1072I; 11:64266150-64266150	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2384G>A; p.R795H; 11:64263526-64263526	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.659T>G; p.L220R; 11:64255782-64255782	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.3256A>C; p.M1086L; 11:64266192-64266192	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2119C>T; p.R707W; 11:64262487-64262487	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2119C>T; p.R707W; 11:64262487-64262487	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2262C>T; p.L754L; 11:64262715-64262715	skin	malignant_melanoma	Substitution - coding silent
c.822G>A; p.L274L; 11:64256499-64256499	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.822G>A; p.L274L; 11:64256499-64256499	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.977A>G; p.Y326C; 11:64256729-64256729	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1469G>A; p.S490N; 11:64259188-64259188	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1124C>T; p.P375L; 11:64258584-64258584	skin	malignant_melanoma	Substitution - Missense
c.627C>T; p.S209S; 11:64255750-64255750	skin	malignant_melanoma	Substitution - coding silent
c.2737C>T; p.L913L; 11:64265035-64265035	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2595C>T; p.H865H; 11:64264055-64264055	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2595C>T; p.H865H; 11:64264055-64264055	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.131G>A; p.R44H; 11:64254446-64254446	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.643C>T; p.R215W; 11:64255766-64255766	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.643C>T; p.R215W; 11:64255766-64255766	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1448G>A; p.R483H; 11:64259167-64259167	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1448G>A; p.R483H; 11:64259167-64259167	thyroid	other; neoplasm	Substitution - Missense
c.1448G>A; p.R483H; 11:64259167-64259167	thyroid	other; neoplasm	Substitution - Missense
c.2567C>T; p.A856V; 11:64264027-64264027	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1745G>T; p.S582I; 11:64261413-64261413	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2567C>T; p.A856V; 11:64264027-64264027	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2860C>T; p.L954L; 11:64265327-64265327	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1372G>T; p.D458Y; 11:64259091-64259091	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.512C>T; p.P171L; 11:64255440-64255440	skin	malignant_melanoma	Substitution - Missense
c.2753G>C; p.R918P; 11:64265051-64265051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2872C>T; p.R958*; 11:64265339-64265339	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1876A>G; p.M626V; 11:64261628-64261628	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2753G>C; p.R918P; 11:64265051-64265051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2753G>C; p.R918P; 11:64265051-64265051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1192G>T; p.E398*; 11:64258652-64258652	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1248G>T; p.V416V; 11:64258708-64258708	skin	malignant_melanoma	Substitution - coding silent
c.906C>T; p.G302G; 11:64256658-64256658	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1247T>C; p.V416A; 11:64258707-64258707	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1634G>A; p.R545Q; 11:64260137-64260137	oesophagus	carcinoma	Substitution - Missense
c.2922G>A; p.L974L; 11:64265389-64265389	prostate	carcinoma	Substitution - coding silent
c.2857C>T; p.P953S; 11:64265324-64265324	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.834G>C; p.K278N; 11:64256511-64256511	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.335C>T; p.P112L; 11:64254986-64254986	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.591C>T; p.F197F; 11:64255610-64255610	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2231G>A; p.G744D; 11:64262684-64262684	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2747delC; p.R918fs*95; 11:64265045-64265045	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2747delC; p.R918fs*95; 11:64265045-64265045	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3079G>A; p.E1027K; 11:64265929-64265929	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.951G>A; p.T317T; 11:64256703-64256703	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.97G>A; p.E33K; 11:64251746-64251746	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2120G>A; p.R707Q; 11:64262488-64262488	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1629G>T; p.L543L; 11:64260132-64260132	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1669G>T; p.D557Y; 11:64260172-64260172	oesophagus	carcinoma	Substitution - Missense
c.921C>T; p.I307I; 11:64256673-64256673	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.708_709GG>AA; p.G237S; 11:64256385-64256386	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.887T>G; p.F296C; 11:64256639-64256639	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2748C>T; p.S916S; 11:64265046-64265046	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.887T>G; p.F296C; 11:64256639-64256639	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1223T>C; p.V408A; 11:64258683-64258683	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1747G>A; p.E583K; 11:64261415-64261415	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2828C>T; p.A943V; 11:64265213-64265213	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3690G>A; p.E1230E; 11:64267541-64267541	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2173G>A; p.A725T; 11:64262541-64262541	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.273C>T; p.G91G; 11:64254924-64254924	skin	malignant_melanoma	Substitution - coding silent
c.2383delC; p.R795fs*12; 11:64263525-64263525	prostate	carcinoma	Deletion - Frameshift
c.2285A>G; p.Y762C; 11:64262738-64262738	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2116C>T; p.R706W; 11:64262484-64262484	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.2566G>A; p.A856T; 11:64264026-64264026	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3601G>T; p.D1201Y; 11:64267452-64267452	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2632G>A; p.A878T; 11:64264092-64264092	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1093G>A; p.V365M; 11:64258553-64258553	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1080C>T; p.C360C; 11:64258540-64258540	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.828C>T; p.I276I; 11:64256505-64256505	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1854G>A; p.S618S; 11:64261606-64261606	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.467C>T; p.A156V; 11:64255313-64255313	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3365C>A; p.T1122K; 11:64266503-64266503	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1213C>G; p.P405A; 11:64258673-64258673	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.764G>A; p.R255H; 11:64256441-64256441	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.829G>A; p.E277K; 11:64256506-64256506	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.473C>T; p.T158M; 11:64255401-64255401	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2551G>A; p.D851N; 11:64263786-64263786	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2137G>A; p.D713N; 11:64262505-64262505	thyroid	other; neoplasm	Substitution - Missense
c.709G>T; p.G237C; 11:64256386-64256386	thyroid	other; neoplasm	Substitution - Missense
c.2507C>T; p.P836L; 11:64263742-64263742	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1108C>T; p.P370S; 11:64258568-64258568	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1108C>T; p.P370S; 11:64258568-64258568	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.3291C>G; p.I1097M; 11:64266339-64266339	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.3233C>A; p.T1078N; 11:64266169-64266169	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1125C>A; p.P375P; 11:64258585-64258585	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2923C>T; p.R975W; 11:64265390-64265390	breast	carcinoma	Substitution - Missense
c.1771T>G; p.S591A; 11:64261439-64261439	thyroid	carcinoma	Substitution - Missense
c.2958C>T; p.V986V; 11:64265425-64265425	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2206C>T; p.Q736*; 11:64262659-64262659	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.107C>T; p.S36F; 11:64254422-64254422	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1422C>T; p.S474S; 11:64259141-64259141	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2527G>A; p.E843K; 11:64263762-64263762	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1959C>T; p.R653R; 11:64261997-64261997	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1791C>T; p.I597I; 11:64261459-64261459	skin	malignant_melanoma	Substitution - coding silent
c.1128C>G; p.F376L; 11:64258588-64258588	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2343C>T; p.F781F; 11:64262796-64262796	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2079C>T; p.N693N; 11:64262447-64262447	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1293C>G; p.S431S; 11:64258924-64258924	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.130C>T; p.R44C; 11:64254445-64254445	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.130C>T; p.R44C; 11:64254445-64254445	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1076G>A; p.R359H; 11:64258536-64258536	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1076G>A; p.R359H; 11:64258536-64258536	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1553G>T; p.G518V; 11:64260056-64260056	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1317C>T; p.I439I; 11:64258948-64258948	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - coding silent
c.1098G>A; p.W366*; 11:64258558-64258558	breast	carcinoma	Substitution - Nonsense
c.1047G>A; p.M349I; 11:64258507-64258507	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.581G>T; p.G194V; 11:64255600-64255600	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1029G>T; p.G343G; 11:64258489-64258489	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1029G>T; p.G343G; 11:64258489-64258489	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.3274A>T; p.K1092*; 11:64266322-64266322	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.260G>A; p.R87Q; 11:64254911-64254911	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3532G>A; p.E1178K; 11:64267383-64267383	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.554G>T; p.R185L; 11:64255573-64255573	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3379C>T; p.R1127W; 11:64266517-64266517	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1778T>G; p.L593R; 11:64261446-64261446	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1442C>T; p.A481V; 11:64259161-64259161	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2629G>T; p.A877S; 11:64264089-64264089	skin	malignant_melanoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]