Entrez Gene

Basic Information
Gene ID	5331
Name	PLCB3
Synonymous	-;phospholipase C, beta 3 (phosphatidylinositol-specific);PLCB3;phospholipase C, beta 3 (phosphatidylinositol-specific)
Definition	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3\|PLC beta 3\|PLC-beta-3\|phosphoinositide phospholipase C-beta-3
Position	11q13
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
NHERF-2(h) + PLCbeta3(h) <==> NHERF-2(h):PLCbeta3(h) (binding)
PLCbeta3(h) + ATP --PKCbeta1(h)--> PLCbeta3(h){p} + ADP (phosphorylation)
PLCbeta3(h) + ATP --PKCgamma(h)--> PLCbeta3(h){p} + ADP (phosphorylation)
PLCbeta3(h) + NHERF-2(h) + edg4-xbb2(h) <==> PLCbeta3(h):NHERF-2(h):edg4-xbb2(h) (binding)
PLCbeta3(h) + RGS12(h) <==> PLCbeta3(h):RGS12(h) (binding)
G-beta(b):G-gamma(b) --> PLCbeta3(h) (binding)
PLCB3(h) --> PLCbeta3(h) (expression).
G-beta-1(b):G-gamma-2(b) --> PLCbeta3(h) (activation)
PIP2 --PLCbeta3(h)--> DAG + IP3 (hydrolysis)
PLCbeta3(h) + G-alpha-q(h) <==> PLCbeta3(h):G-alpha-q(h) (binding)
PLCbeta3(h) + Rac1(h):GTP <==> PLCbeta3(h):Rac1(h):GTP (binding)
PLCbeta3(h) + Rac2(h):GTP <==> PLCbeta3(h):Rac2(h):GTP (binding)
PLCbeta3(h) + Rac3(h):GTP <==> PLCbeta3(h):Rac3(h):GTP (binding)
G-beta-1(b):G-gamma-2(b) + PLCbeta3(h) <==> PLCbeta3(h):G-beta-1(b):G-gamma-2(b) (binding)
PLCB3(h) --> PLCbeta3(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
537	Phosphoserine.		Swiss-Prot 53.0
1122	Phosphothreonine.		Swiss-Prot 53.0
26	Phosphoserine (PKG2/cGK-II)	11278298	Phospho.ELM 6.0
1105	Phosphoserine (PKC alpha;PK)	11278298;15302935;10893237;9660757	Phospho.ELM 6.0