Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5516

Name

PPP2CB

Synonymous

protein phosphatase 2, catalytic subunit, beta isozyme;PPP2CB;protein phosphatase 2, catalytic subunit, beta isozyme

Definition

PP2A-beta|protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform|protein phosphatase 2, catalytic subunit, beta isoform|protein phosphatase 2A catalytic subunit, beta isoform|protein phosphatase type 2A catalytic subunit|serine/threonine pro

Position

8p12

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.17.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.849A>C; p.K283N; 8:30791205-30791205

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.922_924delTTC; p.F308delF; 8:30786241-30786243

 livercarcinomaDeletion - In frame

c.915A>C; p.P305P; 8:30786250-30786250

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.316C>T; p.R106C; 8:30797751-30797751

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.616C>T; p.R206C; 8:30794039-30794039

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.616C>T; p.R206C; 8:30794039-30794039

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.146G>A; p.R49H; 8:30799712-30799712

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.687C>T; p.N229N; 8:30793968-30793968

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.635C>A; p.S212*; 8:30794020-30794020

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.640C>T; p.R214C; 8:30794015-30794015

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.285G>C; p.E95D; 8:30799573-30799573

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.502G>C; p.G168R; 8:30794266-30794266

 breastcarcinomaSubstitution - Missense

c.152C>T; p.P51L; 8:30799706-30799706

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.803G>A; p.R268H; 8:30791251-30791251

 breastcarcinomaSubstitution - Missense

c.509T>A; p.L170H; 8:30794259-30794259

 skin; earcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.514C>T; p.P172S; 8:30794254-30794254

 skinmalignant_melanomaSubstitution - Missense

c.312G>T; p.K104N; 8:30799546-30799546

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.188A>G; p.H63R; 8:30799670-30799670

 pancreascarcinomaSubstitution - Missense

c.746A>G; p.N249S; 8:30791308-30791308

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.724C>G; p.Q242E; 8:30793931-30793931

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.337A>G; p.I113V; 8:30797730-30797730

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.337A>G; p.I113V; 8:30797730-30797730

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.469G>A; p.A157T; 8:30797598-30797598

 skinmalignant_melanomaSubstitution - Missense

c.647C>T; p.A216V; 8:30794008-30794008

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.487-3T>G; p.?; 8:30794284-30794284

 stomachcarcinoma; intestinal_adenocarcinomaUnknown

c.858-8A>G; p.?; 8:30786315-30786315

 livercarcinomaUnknown

c.858-8A>G; p.?; 8:30786315-30786315

 livercarcinomaUnknown

c.193C>A; p.L65I; 8:30799665-30799665

 pancreaspancreatic_intraepithelial_neoplasia_(PanIN)Substitution - Missense

c.739G>T; p.G247*; 8:30791315-30791315

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.443A>G; p.D148G; 8:30797624-30797624

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.403C>T; p.R135*; 8:30797664-30797664

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Nonsense

c.733A>G; p.M245V; 8:30793922-30793922

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.740G>T; p.G247V; 8:30791314-30791314

 livercarcinomaSubstitution - Missense

c.467C>T; p.T156I; 8:30797600-30797600

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.653A>G; p.Y218C; 8:30794002-30794002

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.404G>A; p.R135Q; 8:30797663-30797663

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.73G>C; p.E25Q; 8:30812349-30812349

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.930A>C; p.*310Y; 8:30786235-30786235

 endometriumcarcinoma; endometrioid_carcinomaNonstop extension

c.428G>T; p.W143L; 8:30797639-30797639

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.229G>T; p.D77Y; 8:30799629-30799629

 breastcarcinomaSubstitution - Missense

c.354C>T; p.H118H; 8:30797713-30797713

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

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