Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

56475

Name

RPRM

Synonymous

reprimo, TP53 dependent G2 arrest mediator candidate;RPRM;reprimo, TP53 dependent G2 arrest mediator candidate

Definition

candidate mediator of the p53 dependent G2 arrest|candidate mediator of the p53-dependent G2 arrest|protein reprimo|reprimo, TP53 dependant G2 arrest mediator candidate

Position

2q23.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.182T>C; p.V61A; 2:153478384-153478384

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.238C>G; p.L80V; 2:153478328-153478328

 breastcarcinomaSubstitution - Missense

c.310G>A; p.V104M; 2:153478256-153478256

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.310G>A; p.V104M; 2:153478256-153478256

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.81G>A; p.V27V; 2:153478485-153478485

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.85T>C; p.C29R; 2:153478481-153478481

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.43T>G; p.F15V; 2:153478523-153478523

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.238C>T; p.L80L; 2:153478328-153478328

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.180G>A; p.A60A; 2:153478386-153478386

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.74G>A; p.R25Q; 2:153478492-153478492

 skinmalignant_melanomaSubstitution - Missense

c.16G>A; p.G6S; 2:153478550-153478550

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.137C>A; p.P46Q; 2:153478429-153478429

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.287G>A; p.R96K; 2:153478279-153478279

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.203C>T; p.T68I; 2:153478363-153478363

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.99G>A; p.A33A; 2:153478467-153478467

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.139G>A; p.D47N; 2:153478427-153478427

 prostatecarcinomaSubstitution - Missense

c.228C>T; p.L76L; 2:153478338-153478338

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.274G>A; p.V92M; 2:153478292-153478292

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.137C>T; p.P46L; 2:153478429-153478429

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.190G>A; p.V64M; 2:153478376-153478376

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.167T>G; p.V56G; 2:153478399-153478399

 bone; tibiaEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.79G>A; p.V27M; 2:153478487-153478487

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.124G>A; p.A42T; 2:153478442-153478442

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.291G>A; p.P97P; 2:153478275-153478275

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.102C>T; p.S34S; 2:153478464-153478464

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.291G>A; p.P97P; 2:153478275-153478275

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.39C>A; p.G13G; 2:153478527-153478527

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.61G>A; p.E21K; 2:153478505-153478505

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.131G>A; p.G44E; 2:153478435-153478435

 skinmalignant_melanomaSubstitution - Missense

c.287G>T; p.R96M; 2:153478279-153478279

 large_intestine; coloncarcinomaSubstitution - Missense

c.164G>A; p.R55H; 2:153478402-153478402

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.192G>C; p.V64V; 2:153478374-153478374

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.192G>C; p.V64V; 2:153478374-153478374

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.27G>T; p.T9T; 2:153478539-153478539

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.319G>A; p.G107R; 2:153478247-153478247

 skinmalignant_melanomaSubstitution - Missense

c.138G>A; p.P46P; 2:153478428-153478428

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

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