Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

56940

Name

DUSP22

Synonymous

dual specificity phosphatase 22;DUSP22;dual specificity phosphatase 22

Definition

JNK-stimulating phosphatase 1|JNK-stimulatory phosphatase-1|MAP kinase phosphatase x|dual specificity protein phosphatase 22|homolog of mouse dual specificity phosphatase LMW-DSP2|low molecular weight dual specificity phosphatase 2|mitogen-activated prote

Position

6p25.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.12.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.310A>G; p.M104V; 6:348149-348149

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.279C>T; p.S93S; 6:348118-348118

 livercarcinomaSubstitution - coding silent

c.283A>T; p.S95C; 6:348122-348122

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.70G>T; p.E24*; 6:311894-311894

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.283A>T; p.S95C; 6:348122-348122

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.283A>T; p.S95C; 6:348122-348122

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.425A>G; p.E142G; 6:348264-348264

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.149A>G; p.Y50C; 6:335124-335124

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.306C>T; p.Y102Y; 6:348145-348145

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.426G>T; p.E142D; 6:348265-348265

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.301G>A; p.A101T; 6:348140-348140

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.281G>T; p.R94M; 6:348120-348120

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.297G>A; p.V99V; 6:348136-348136

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.463G>T; p.G155*; 6:348796-348796

 livercarcinoma; hepatocellular_carcinomaSubstitution - Nonsense

c.378delC; p.N128fs*23; 6:348217-348217

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.518G>A; p.G173E; 6:350831-350831

 skinmalignant_melanomaSubstitution - Missense

c.433C>T; p.Q145*; 6:348272-348272

 central_nervous_system; braingliomaSubstitution - Nonsense

c.300C>A; p.I100I; 6:348139-348139

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.442C>T; p.Q148*; 6:348775-348775

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.342C>T; p.A114A; 6:348181-348181

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.441G>T; p.R147R; 6:348774-348774

 central_nervous_system; braingliomaSubstitution - coding silent

c.300C>T; p.I100I; 6:348139-348139

 skinmalignant_melanomaSubstitution - coding silent

c.300C>T; p.I100I; 6:348139-348139

 skinmalignant_melanomaSubstitution - coding silent

c.300C>T; p.I100I; 6:348139-348139

 skinmalignant_melanomaSubstitution - coding silent

c.241G>A; p.G81S; 6:345906-345906

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.115G>A; p.D39N; 6:311939-311939

 skinmalignant_melanomaSubstitution - Missense

c.517G>A; p.G173R; 6:350830-350830

 skinmalignant_melanomaSubstitution - Missense

c.115G>A; p.D39N; 6:311939-311939

 skinmalignant_melanomaSubstitution - Missense

c.435+1G>T; p.?; 6:348275-348275

 livercarcinomaUnknown

c.122C>T; p.A41V; 6:311946-311946

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.120T>G; p.S40R; 6:311944-311944

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.233G>A; p.R78Q; 6:345898-345898

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.267G>T; p.L89L; 6:348106-348106

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.548G>T; p.R183I; 6:350861-350861

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.5G>A; p.G2E; 6:292544-292544

 skinmalignant_melanomaSubstitution - Missense

c.513T>G; p.A171A; 6:350826-350826

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.485C>A; p.A162E; 6:348818-348818

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.486A>G; p.A162A; 6:348819-348819

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.486A>G; p.A162A; 6:348819-348819

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.450G>C; p.L150L; 6:348783-348783

 autonomic_ganglianeuroblastomaSubstitution - coding silent

c.271G>T; p.G91W; 6:348110-348110

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.317T>C; p.V106A; 6:348156-348156

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.223C>T; p.H75Y; 6:345888-345888

 livercarcinomaSubstitution - Missense

c.485C>T; p.A162V; 6:348818-348818

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.223C>T; p.H75Y; 6:345888-345888

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.228G>C; p.E76D; 6:345893-345893

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.525G>A; p.L175L; 6:350838-350838

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.525G>A; p.L175L; 6:350838-350838

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.142G>T; p.V48F; 6:335117-335117

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.139-1G>T; p.?; 6:335113-335113

 lungcarcinoma; adenocarcinomaUnknown

c.484G>C; p.A162P; 6:348817-348817

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.168G>A; p.A56A; 6:335143-335143

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.124A>C; p.R42R; 6:311948-311948

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.139-2A>T; p.?; 6:335112-335112

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.484G>A; p.A162T; 6:348817-348817

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.167C>T; p.A56V; 6:335142-335142

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.167C>T; p.A56V; 6:335142-335142

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.270C>T; p.A90A; 6:348109-348109

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.439C>T; p.R147W; 6:348772-348772

 skinmalignant_melanomaSubstitution - Missense

c.439C>T; p.R147W; 6:348772-348772

 skinmalignant_melanomaSubstitution - Missense

c.112C>A; p.H38N; 6:311936-311936

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.463G>A; p.G155R; 6:348796-348796

 skinmalignant_melanomaSubstitution - Missense

c.463G>A; p.G155R; 6:348796-348796

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.258A>C; p.V86V; 6:345923-345923

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.408G>A; p.Q136Q; 6:348247-348247

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.408G>A; p.Q136Q; 6:348247-348247

 livercarcinomaSubstitution - coding silent

c.351C>T; p.T117T; 6:348190-348190

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.286G>A; p.V96M; 6:348125-348125

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.466G>A; p.E156K; 6:348799-348799

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.286G>A; p.V96M; 6:348125-348125

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.389G>A; p.G130D; 6:348228-348228

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.316G>A; p.V106I; 6:348155-348155

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.316G>A; p.V106I; 6:348155-348155

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.365G>A; p.R122K; 6:348204-348204

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.352G>A; p.V118M; 6:348191-348191

 pancreascarcinomaSubstitution - Missense

c.352G>A; p.V118M; 6:348191-348191

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.205G>T; p.E69*; 6:345870-345870

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.205G>T; p.E69*; 6:345870-345870

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.405C>T; p.L135L; 6:348244-348244

 skinmalignant_melanomaSubstitution - coding silent

c.70G>A; p.E24K; 6:311894-311894

 skin; extremitymalignant_melanomaSubstitution - Missense

c.352G>T; p.V118L; 6:348191-348191

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.240C>T; p.R80R; 6:345905-345905

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.366A>G; p.R122R; 6:348205-348205

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.378C>A; p.N126K; 6:348217-348217

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.189G>T; p.L63L; 6:345854-345854

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.32G>A; p.G11D; 6:304638-304638

 skinmalignant_melanomaSubstitution - Missense

c.219C>T; p.F73F; 6:345884-345884

 skinmalignant_melanomaSubstitution - coding silent

c.239G>A; p.R80H; 6:345904-345904

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.239G>A; p.R80H; 6:345904-345904

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.495_500delCAAAAA; p.K166_N167delKN; 6:348828-348833

 large_intestinecarcinoma; adenocarcinomaDeletion - In frame

c.511G>T; p.A171S; 6:350824-350824

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.438T>C; p.Y146Y; 6:348771-348771

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.531C>A; p.F177L; 6:350844-350844

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.464G>A; p.G155E; 6:348797-348797

 skinmalignant_melanomaSubstitution - Missense

c.385G>A; p.V129M; 6:348224-348224

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.173C>T; p.S58L; 6:335148-335148

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.173C>T; p.S58L; 6:335148-335148

 skinmalignant_melanomaSubstitution - Missense

c.330C>T; p.G110G; 6:348169-348169

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.168G>T; p.A56A; 6:335143-335143

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.355C>T; p.R119C; 6:348194-348194

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.300C>G; p.I100M; 6:348139-348139

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.355C>T; p.R119C; 6:348194-348194

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.371G>T; p.C124F; 6:348210-348210

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.371G>T; p.C124F; 6:348210-348210

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.4G>A; p.G2R; 6:292543-292543

 skin; legmalignant_melanomaSubstitution - Missense

c.534G>A; p.W178*; 6:350847-350847

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

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