| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 56998 |
Name | CTNNBIP1 |
Synonymous | catenin, beta interacting protein 1;CTNNBIP1;catenin, beta interacting protein 1 |
Definition | beta-catenin-interacting protein 1|beta-catenin-interacting protein ICAT|inhibitor of beta-catenin and Tcf-4 |
Position | 1p36.22 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.33. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.86T>C; p.M29T; 1:9871979-9871979 |
skin | malignant_melanoma | Substitution - Missense |
c.121C>A; p.L41M; 1:9871253-9871253 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.49C>T; p.Q17*; 1:9872016-9872016 |
cervix | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.204G>A; p.V68V; 1:9850760-9850760 |
ovary | carcinoma; serous_carcinoma | Substitution - coding silent |
c.32C>T; p.P11L; 1:9872033-9872033 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.184C>G; p.Q62E; 1:9871190-9871190 |
ovary | other; neoplasm | Substitution - Missense |
c.22G>A; p.G8R; 1:9872043-9872043 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.203T>C; p.V68A; 1:9850761-9850761 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.10G>T; p.E4*; 1:9872055-9872055 |
urinary_tract; bladder | carcinoma | Substitution - Nonsense |
c.240G>A; p.R80R; 1:9850724-9850724 |
breast | carcinoma | Substitution - coding silent |
c.198C>T; p.D66D; 1:9850766-9850766 |
lung | carcinoma; small_cell_carcinoma | Substitution - coding silent |
c.129C>T; p.T43T; 1:9871245-9871245 |
skin | malignant_melanoma | Substitution - coding silent |
c.129C>T; p.T43T; 1:9871245-9871245 |
prostate | carcinoma; adenocarcinoma | Substitution - coding silent |
c.92C>T; p.S31L; 1:9871973-9871973 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.115G>C; p.E39Q; 1:9871259-9871259 |
urinary_tract; bladder | carcinoma | Substitution - Missense |