| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5889 |
Name | RAD51C |
Synonymous | RAD51 paralog C;RAD51C;RAD51 paralog C |
Definition | DNA repair protein RAD51 homolog 3|RAD51-like protein 2|yeast RAD51 homolog 3 |
Position | 17q22 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.25. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.12G>A; p.K4K; 17:58692655-58692655 |
oesophagus | carcinoma; adenocarcinoma | Substitution - coding silent |
c.354G>A; p.M118I; 17:58695139-58695139 |
upper_aerodigestive_tract; pharynx | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.211A>G; p.N71D; 17:58694996-58694996 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.259G>A; p.A87T; 17:58695044-58695044 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.135G>C; p.E45D; 17:58692778-58692778 |
biliary_tract; bile_duct | carcinoma; adenocarcinoma | Substitution - Missense |
c.61C>T; p.P21S; 17:58692704-58692704 |
breast | carcinoma | Substitution - Missense |
c.145+1G>A; p.?; 17:58692789-58692789 |
endometrium | carcinoma; endometrioid_carcinoma | Unknown |
c.61C>A; p.P21T; 17:58692704-58692704 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.314delC; p.S105fs*1; 17:58695099-58695099 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.52C>T; p.P18S; 17:58692695-58692695 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.234A>G; p.T78T; 17:58695019-58695019 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - coding silent |