Entrez Gene

Basic Information
Gene ID	6196
Name	RPS6KA2
Synonymous	ribosomal protein S6 kinase, 90kDa, polypeptide 2;RPS6KA2;ribosomal protein S6 kinase, 90kDa, polypeptide 2
Definition	90 kDa ribosomal protein S6 kinase 2\|MAP kinase-activated protein kinase 1c\|MAPK-activated protein kinase 1c\|MAPKAP kinase 1c\|MAPKAPK-1c\|RSK-3\|S6K-alpha-2\|p90-RSK 2\|p90RSK2\|ribosomal S6 kinase 3\|ribosomal protein S6 kinase 90kDa polypeptide 2\|ribosomal pr
Position	6q27
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.14.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1665C>T; p.F555F; 6:166423334-166423334	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1665C>T; p.F555F; 6:166423334-166423334	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1237G>A; p.D413N; 6:166448819-166448819	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.132C>T; p.S44S; 6:166538752-166538752	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.837G>A; p.P279P; 6:166488903-166488903	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.45T>C; p.S15S; 6:166626975-166626975	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.720C>T; p.A240A; 6:166498535-166498535	liver	carcinoma	Substitution - coding silent
c.720C>T; p.A240A; 6:166498535-166498535	liver	carcinoma	Substitution - coding silent
c.837G>A; p.P279P; 6:166488903-166488903	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.720C>T; p.A240A; 6:166498535-166498535	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1956G>C; p.M652I; 6:166413914-166413914	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.45T>C; p.S15S; 6:166626975-166626975	thyroid	other; neoplasm	Substitution - coding silent
c.1005C>T; p.F335F; 6:166459519-166459519	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1852A>G; p.T618A; 6:166418311-166418311	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1005C>T; p.F335F; 6:166459519-166459519	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.521A>T; p.H174L; 6:166504551-166504551	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.162A>G; p.A54A; 6:166538722-166538722	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1688delC; p.A563fs*7; 6:166423311-166423311	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.162A>G; p.A54A; 6:166538722-166538722	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2120A>G; p.Q707R; 6:166412844-166412844	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.402C>T; p.L134L; 6:166508260-166508260	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1953G>T; p.K651N; 6:166413917-166413917	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.802A>G; p.M268V; 6:166490687-166490687	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1310C>T; p.T437I; 6:166448746-166448746	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.567C>A; p.N189K; 6:166500924-166500924	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1103A>G; p.N368S; 6:166451206-166451206	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1081C>A; p.P361T; 6:166451228-166451228	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2148A>G; p.S716S; 6:166412816-166412816	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2148A>G; p.S716S; 6:166412816-166412816	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2148A>G; p.S716S; 6:166412816-166412816	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2148A>G; p.S716S; 6:166412816-166412816	thyroid	other; neoplasm	Substitution - coding silent
c.2148A>G; p.S716S; 6:166412816-166412816	thyroid	other; neoplasm	Substitution - coding silent
c.684C>T; p.P228P; 6:166498571-166498571	skin	malignant_melanoma	Substitution - coding silent
c.378T>A; p.Y126*; 6:166510278-166510278	pancreas	carcinoma	Substitution - Nonsense
c.710C>T; p.T237M; 6:166498545-166498545	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1361C>T; p.S454L; 6:166432462-166432462	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2037C>T; p.S679S; 6:166413833-166413833	NS	malignant_melanoma	Substitution - coding silent
c.2037C>T; p.S679S; 6:166413833-166413833	NS	malignant_melanoma	Substitution - coding silent
c.1666G>A; p.G556S; 6:166423333-166423333	prostate	carcinoma	Substitution - Missense
c.2054G>T; p.R685L; 6:166413816-166413816	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1108C>T; p.H370Y; 6:166451201-166451201	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1989G>A; p.A663A; 6:166413881-166413881	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.509T>A; p.L170*; 6:166504563-166504563	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1468C>T; p.R490C; 6:166430566-166430566	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1312G>A; p.D438N; 6:166448744-166448744	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1739C>T; p.P580L; 6:166423260-166423260	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1739C>T; p.P580L; 6:166423260-166423260	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1631C>T; p.S544L; 6:166423368-166423368	skin; scalp	malignant_melanoma	Substitution - Missense
c.265G>A; p.A89T; 6:166531265-166531265	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.352C>T; p.H118Y; 6:166510304-166510304	skin	malignant_melanoma	Substitution - Missense
c.736G>A; p.G246S; 6:166498519-166498519	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.352C>T; p.H118Y; 6:166510304-166510304	skin	malignant_melanoma	Substitution - Missense
c.1174C>T; p.L392L; 6:166451135-166451135	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.314G>A; p.R105K; 6:166510342-166510342	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1339G>T; p.D447Y; 6:166432484-166432484	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1027G>A; p.E343K; 6:166459497-166459497	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1499G>A; p.R500Q; 6:166430535-166430535	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1829C>T; p.P610L; 6:166418334-166418334	skin; trunk	malignant_melanoma	Substitution - Missense
c.1063C>T; p.R355W; 6:166459461-166459461	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1063C>T; p.R355W; 6:166459461-166459461	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.178G>C; p.E60Q; 6:166538706-166538706	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1876A>T; p.I626F; 6:166418287-166418287	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.267C>T; p.A89A; 6:166531263-166531263	skin	malignant_melanoma	Substitution - coding silent
c.103G>A; p.E35K; 6:166538781-166538781	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.941G>A; p.R314H; 6:166469872-166469872	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.732C>A; p.S244S; 6:166498523-166498523	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.338T>C; p.L113S; 6:166510318-166510318	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.39C>A; p.F13L; 6:166626981-166626981	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.286G>A; p.A96T; 6:166531244-166531244	skin	malignant_melanoma	Substitution - Missense
c.1945G>A; p.V649M; 6:166413925-166413925	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.389C>T; p.T130M; 6:166508273-166508273	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1448A>G; p.Y483C; 6:166430586-166430586	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.940C>T; p.R314C; 6:166469873-166469873	meninges	meningioma	Substitution - Missense
c.1690G>A; p.G564R; 6:166423309-166423309	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1772C>T; p.A591V; 6:166419930-166419930	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.648G>A; p.A216A; 6:166498607-166498607	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2187G>C; p.T729T; 6:166412777-166412777	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2187G>C; p.T729T; 6:166412777-166412777	thyroid	other; neoplasm	Substitution - coding silent
c.636C>T; p.H212H; 6:166498619-166498619	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1050C>T; p.P350P; 6:166459474-166459474	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.317C>A; p.S106*; 6:166510339-166510339	breast	carcinoma	Substitution - Nonsense
c.1490G>A; p.R497H; 6:166430544-166430544	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.470C>T; p.T157M; 6:166504602-166504602	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.1482C>T; p.L494L; 6:166430552-166430552	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1741G>A; p.E581K; 6:166423258-166423258	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2053C>T; p.R685*; 6:166413817-166413817	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2197C>T; p.L733L; 6:166412767-166412767	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2197C>T; p.L733L; 6:166412767-166412767	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2197C>T; p.L733L; 6:166412767-166412767	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2197C>T; p.L733L; 6:166412767-166412767	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1317C>T; p.T439T; 6:166448739-166448739	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1317C>T; p.T439T; 6:166448739-166448739	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.466T>C; p.F156L; 6:166504606-166504606	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1696G>A; p.G566R; 6:166423303-166423303	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1031A>G; p.D344G; 6:166459493-166459493	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1801T>G; p.L601V; 6:166419901-166419901	breast	carcinoma	Substitution - Missense
c.460-1G>T; p.?; 6:166504613-166504613	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1396C>T; p.H466Y; 6:166432427-166432427	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1685G>A; p.R562H; 6:166423314-166423314	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1840G>A; p.G614R; 6:166418323-166418323	skin	malignant_melanoma	Substitution - Missense
c.931G>A; p.E311K; 6:166469882-166469882	skin	malignant_melanoma	Substitution - Missense
c.931G>A; p.E311K; 6:166469882-166469882	skin	malignant_melanoma	Substitution - Missense
c.931G>A; p.E311K; 6:166469882-166469882	skin	malignant_melanoma	Substitution - Missense
c.931G>A; p.E311K; 6:166469882-166469882	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.343G>A; p.E115K; 6:166510313-166510313	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1769C>T; p.A590V; 6:166419933-166419933	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1753C>T; p.R585C; 6:166419949-166419949	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.611G>A; p.G204D; 6:166498644-166498644	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1769C>T; p.A590V; 6:166419933-166419933	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.611G>A; p.G204D; 6:166498644-166498644	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1686C>T; p.R562R; 6:166423313-166423313	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1686C>T; p.R562R; 6:166423313-166423313	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.287C>A; p.A96D; 6:166531243-166531243	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1775G>A; p.C592Y; 6:166419927-166419927	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.697C>T; p.R233W; 6:166498558-166498558	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1849G>A; p.D617N; 6:166418314-166418314	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1917C>A; p.D639E; 6:166418246-166418246	breast	carcinoma	Substitution - Missense
c.1395G>T; p.Q465H; 6:166432428-166432428	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.109G>A; p.V37I; 6:166538775-166538775	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1515G>A; p.S505S; 6:166430519-166430519	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1515G>A; p.S505S; 6:166430519-166430519	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.103G>C; p.E35Q; 6:166538781-166538781	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1577A>G; p.Q526R; 6:166430457-166430457	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.462C>G; p.V154V; 6:166504610-166504610	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1104C>T; p.N368N; 6:166451205-166451205	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1581+1G>A; p.?; 6:166430452-166430452	ovary	carcinoma; mucinous_carcinoma	Unknown
c.1581+1G>A; p.?; 6:166430452-166430452	ovary	carcinoma; mucinous_carcinoma	Unknown
c.373C>A; p.H125N; 6:166510283-166510283	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.226G>A; p.V76M; 6:166531304-166531304	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.37T>A; p.F13I; 6:166626983-166626983	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1825A>G; p.T609A; 6:166418338-166418338	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1087G>A; p.V363I; 6:166451222-166451222	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1087G>A; p.V363I; 6:166451222-166451222	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1798C>T; p.L600L; 6:166419904-166419904	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1897C>T; p.L633F; 6:166418266-166418266	skin	malignant_melanoma	Substitution - Missense
c.1236C>T; p.T412T; 6:166448820-166448820	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1514C>T; p.S505L; 6:166430520-166430520	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1206+1G>A; p.?; 6:166451102-166451102	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.982C>T; p.R328W; 6:166459542-166459542	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1940A>G; p.D647G; 6:166413930-166413930	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1684C>T; p.R562C; 6:166423315-166423315	oesophagus	carcinoma	Substitution - Missense
c.1516G>C; p.E506Q; 6:166430518-166430518	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2077-1G>A; p.?; 6:166412888-166412888	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1854C>T; p.T618T; 6:166418309-166418309	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.700C>T; p.R234*; 6:166498555-166498555	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.426_427GG>TT; p.G143*; 6:166508235-166508236	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2064G>T; p.V688V; 6:166413806-166413806	thyroid	other; neoplasm	Substitution - coding silent
c.1064G>A; p.R355Q; 6:166459460-166459460	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1647C>T; p.S549S; 6:166423352-166423352	liver	carcinoma	Substitution - coding silent
c.1960C>T; p.H654Y; 6:166413910-166413910	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.45T>A; p.S15S; 6:166626975-166626975	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1280C>G; p.S427*; 6:166448776-166448776	lung	carcinoma; non_small_cell_carcinoma	Substitution - Nonsense
c.1280C>G; p.S427*; 6:166448776-166448776	lung	carcinoma; non_small_cell_carcinoma	Substitution - Nonsense
c.1280C>G; p.S427*; 6:166448776-166448776	lung	carcinoma; non_small_cell_carcinoma	Substitution - Nonsense
c.1280C>G; p.S427*; 6:166448776-166448776	lung	carcinoma; non_small_cell_carcinoma	Substitution - Nonsense
c.1763A>G; p.Y588C; 6:166419939-166419939	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1985C>T; p.T662M; 6:166413885-166413885	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.1569C>A; p.L523L; 6:166430465-166430465	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1695C>T; p.N565N; 6:166423304-166423304	pancreas	carcinoma	Substitution - coding silent
c.1279T>C; p.S427P; 6:166448777-166448777	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1722G>A; p.T574T; 6:166423277-166423277	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.301C>T; p.R101W; 6:166510355-166510355	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1627G>A; p.E543K; 6:166423372-166423372	skin	malignant_melanoma	Substitution - Missense
c.665C>T; p.T222M; 6:166498590-166498590	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.665C>T; p.T222M; 6:166498590-166498590	breast	carcinoma	Substitution - Missense
c.552T>G; p.D184E; 6:166504520-166504520	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1464G>A; p.L488L; 6:166430570-166430570	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1823T>G; p.F608C; 6:166418340-166418340	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1919C>T; p.S640L; 6:166418244-166418244	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1280C>A; p.S427*; 6:166448776-166448776	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.563_566+35del39; p.?; 6:166504471-166504509	stomach	carcinoma; intestinal_adenocarcinoma	Unknown
c.1591C>T; p.R531*; 6:166423408-166423408	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2195G>A; p.R732Q; 6:166412769-166412769	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2195G>A; p.R732Q; 6:166412769-166412769	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.222C>T; p.F74F; 6:166531308-166531308	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.947C>T; p.P316L; 6:166469866-166469866	skin	malignant_melanoma	Substitution - Missense
c.568A>G; p.I190V; 6:166500923-166500923	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1773G>A; p.A591A; 6:166419929-166419929	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1688C>T; p.A563V; 6:166423311-166423311	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1688C>T; p.A563V; 6:166423311-166423311	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1095G>A; p.P365P; 6:166451214-166451214	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1258G>A; p.D420N; 6:166448798-166448798	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.133C>T; p.H45Y; 6:166538751-166538751	skin	malignant_melanoma	Substitution - Missense
c.983G>A; p.R328Q; 6:166459541-166459541	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.831G>C; p.G277G; 6:166488909-166488909	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1871C>T; p.A624V; 6:166418292-166418292	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.861G>A; p.Q287Q; 6:166488879-166488879	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2186C>T; p.T729M; 6:166412778-166412778	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.678G>T; p.M226I; 6:166498577-166498577	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1636A>T; p.S546C; 6:166423363-166423363	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1444G>A; p.V482M; 6:166430590-166430590	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.354C>T; p.H118H; 6:166510302-166510302	skin	malignant_melanoma	Substitution - coding silent
c.1963G>A; p.V655M; 6:166413907-166413907	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.468C>G; p.F156L; 6:166504604-166504604	breast	carcinoma	Substitution - Missense
c.156G>A; p.E52E; 6:166538728-166538728	breast	carcinoma	Substitution - coding silent
c.495G>T; p.L165L; 6:166504577-166504577	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.765G>A; p.G255G; 6:166490724-166490724	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2128C>T; p.R710W; 6:166412836-166412836	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2128C>T; p.R710W; 6:166412836-166412836	liver	carcinoma	Substitution - Missense
c.2128C>T; p.R710W; 6:166412836-166412836	liver	carcinoma	Substitution - Missense
c.2054G>A; p.R685Q; 6:166413816-166413816	pancreas	carcinoma	Substitution - Missense
c.100-1G>T; p.?; 6:166538785-166538785	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.520C>A; p.H174N; 6:166504552-166504552	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.959C>T; p.T320I; 6:166469854-166469854	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.207C>A; p.S69S; 6:166538677-166538677	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.711G>A; p.T237T; 6:166498544-166498544	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.148G>A; p.G50S; 6:166538736-166538736	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2192C>T; p.T731M; 6:166412772-166412772	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.259C>T; p.L87F; 6:166531271-166531271	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1225A>G; p.I409V; 6:166448831-166448831	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.259C>T; p.L87F; 6:166531271-166531271	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1760G>T; p.G587V; 6:166419942-166419942	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1281A>G; p.S427S; 6:166448775-166448775	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1910delA; p.N637fs*25; 6:166418253-166418253	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1938+6T>G; p.?; 6:166418219-166418219	liver	carcinoma	Unknown
c.1216G>A; p.G406R; 6:166448840-166448840	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]