| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 638 |
Name | BIK |
Synonymous | BCL2-interacting killer (apoptosis-inducing);BIK;BCL2-interacting killer (apoptosis-inducing) |
Definition | apoptosis inducer NBK|apoptosis-inducing NBK|bcl-2-interacting killer |
Position | 22q13.31 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.33. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.381C>T; p.P127P; 22:43128616-43128616 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.46C>T; p.L16F; 22:43124068-43124068 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.91G>A; p.G31S; 22:43124113-43124113 |
skin | malignant_melanoma | Substitution - Missense |
c.94A>C; p.M32L; 22:43124116-43124116 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.380_381CC>TT; p.P127L; 22:43128615-43128616 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.28G>C; p.D10H; 22:43124050-43124050 |
breast | carcinoma; HER-positive_carcinoma | Substitution - Missense |
c.407_424del18; p.L143_L148delLLALLL; 22:43129229-43129246 |
breast | carcinoma | Deletion - In frame |
c.426_427GC>AA; p.L142>?; 22:43129248-43129249 |
large_intestine; colon | carcinoma; adenocarcinoma | Complex |
c.458G>A; p.G153E; 22:43129280-43129280 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.445C>G; p.P149A; 22:43129267-43129267 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.428_445del18; p.L143_L148delLLALLL; 22:43129250-43129267 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; hairy_cell_leukaemia | Deletion - In frame |
c.483A>T; p.*161C; 22:43129305-43129305 |
large_intestine; colon | carcinoma; adenocarcinoma | Nonstop extension |
c.111_116delGGACCT; p.L39_D40delLD; 22:43124133-43124138 |
oesophagus | carcinoma; adenocarcinoma | Deletion - In frame |
c.429_434delGCTGGC; p.A145_L146delAL; 22:43129251-43129256 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - In frame |
c.185C>T; p.A62V; 22:43127720-43127720 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.283G>A; p.D95N; 22:43128518-43128518 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.447G>T; p.P149P; 22:43129269-43129269 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.193G>T; p.G65W; 22:43127728-43127728 |
kidney | carcinoma; papillary_renal_cell_carcinoma | Substitution - Missense |
c.379C>T; p.P127S; 22:43128614-43128614 |
skin | malignant_melanoma | Substitution - Missense |
c.135C>T; p.F45F; 22:43124157-43124157 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.400G>A; p.E134K; 22:43129222-43129222 |
cervix | carcinoma; squamous_cell_carcinoma | Substitution - Missense |