| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6387 |
Name | CXCL12 |
Synonymous | chemokine (C-X-C motif) ligand 12;CXCL12;chemokine (C-X-C motif) ligand 12 |
Definition | intercrine reduced in hepatomas|pre-B cell growth-stimulating factor|stromal cell-derived factor 1 |
Position | 10q11.1 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.25. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.238C>T; p.Q80*; 10:44378665-44378665 |
lung | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.248T>C; p.L83P; 10:44378655-44378655 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.158C>T; p.P53L; 10:44380784-44380784 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.185_186GG>AA; p.R62>?; 10:44378717-44378718 |
skin; trunk | malignant_melanoma | Complex |
c.232T>C; p.W78R; 10:44378671-44378671 |
pancreas | carcinoma | Substitution - Missense |
c.275A>G; p.K92R; 10:44373335-44373335 |
skin | malignant_melanoma | Substitution - Missense |
c.48C>G; p.L16L; 10:44384958-44384958 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.205C>A; p.Q69K; 10:44378698-44378698 |
liver | carcinoma | Substitution - Missense |
c.205C>A; p.Q69K; 10:44378698-44378698 |
liver | carcinoma | Substitution - Missense |
c.69C>T; p.P23P; 10:44380873-44380873 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - coding silent |
c.74G>A; p.S25N; 10:44380868-44380868 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.250G>T; p.E84*; 10:44378653-44378653 |
liver | carcinoma | Substitution - Nonsense |
c.250G>T; p.E84*; 10:44378653-44378653 |
liver | carcinoma | Substitution - Nonsense |
c.125C>T; p.A42V; 10:44380817-44380817 |
skin | malignant_melanoma | Substitution - Missense |
c.184C>T; p.R62W; 10:44378719-44378719 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.98G>A; p.R33Q; 10:44380844-44380844 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.179+4A>C; p.?; 10:44380759-44380759 |
oesophagus | carcinoma; adenocarcinoma | Unknown |
c.212G>A; p.C71Y; 10:44378691-44378691 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.223A>G; p.K75E; 10:44378680-44378680 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.162C>T; p.N54N; 10:44380780-44380780 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.169C>A; p.L57I; 10:44380773-44380773 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.33C>T; p.L11L; 10:44384973-44384973 |
skin | malignant_melanoma | Substitution - coding silent |
c.62-1G>T; p.?; 10:44380881-44380881 |
skin | malignant_melanoma | Unknown |
c.235A>G; p.I79V; 10:44378668-44378668 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.222G>A; p.P74P; 10:44378681-44378681 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |