| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 650 |
Name | BMP2 |
Synonymous | bone morphogenetic protein 2;BMP2;bone morphogenetic protein 2 |
Definition | BMP-2A|bone morphogenetic protein 2A |
Position | 20p12 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.11. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.1075G>C; p.A359P; 20:6778973-6778973 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.798T>A; p.T266T; 20:6778696-6778696 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.393A>T; p.R131S; 20:6778291-6778291 |
breast | carcinoma | Substitution - Missense |
c.106G>A; p.A36T; 20:6770232-6770232 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.372G>A; p.T124T; 20:6778270-6778270 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.251G>A; p.R84H; 20:6770377-6770377 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.509G>A; p.R170Q; 20:6778407-6778407 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.509G>A; p.R170Q; 20:6778407-6778407 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.509G>A; p.R170Q; 20:6778407-6778407 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.509G>A; p.R170Q; 20:6778407-6778407 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1036C>T; p.Q346*; 20:6778934-6778934 |
breast | carcinoma | Substitution - Nonsense |
c.226C>A; p.P76T; 20:6770352-6770352 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.907G>A; p.V303M; 20:6778805-6778805 |
pancreas | carcinoma | Substitution - Missense |
c.878A>C; p.K293T; 20:6778776-6778776 |
skin | malignant_melanoma | Substitution - Missense |
c.417C>T; p.I139I; 20:6778315-6778315 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.110C>T; p.S37L; 20:6770236-6770236 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.383delC; p.T128fs*9; 20:6778281-6778281 |
bone; pelvis | chondrosarcoma | Deletion - Frameshift |
c.829C>A; p.H277N; 20:6778727-6778727 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.101C>T; p.A34V; 20:6770227-6770227 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.678C>T; p.F226F; 20:6778576-6778576 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.114G>A; p.S38S; 20:6770240-6770240 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.678C>T; p.F226F; 20:6778576-6778576 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.102G>T; p.A34A; 20:6770228-6770228 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.430T>G; p.F144V; 20:6778328-6778328 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.663C>T; p.H221H; 20:6778561-6778561 |
oesophagus | carcinoma; adenocarcinoma | Substitution - coding silent |
c.430T>G; p.F144V; 20:6778328-6778328 |
kidney | carcinoma; renal_cell_carcinoma | Substitution - Missense |
c.186C>T; p.G62G; 20:6770312-6770312 |
skin | malignant_melanoma | Substitution - coding silent |
c.867G>A; p.R289R; 20:6778765-6778765 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1052C>G; p.S351C; 20:6778950-6778950 |
oesophagus | carcinoma | Substitution - Missense |
c.497G>A; p.S166N; 20:6778395-6778395 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.871C>T; p.R291C; 20:6778769-6778769 |
breast | carcinoma | Substitution - Missense |
c.994C>T; p.P332S; 20:6778892-6778892 |
skin | malignant_melanoma | Substitution - Missense |
c.906C>T; p.Y302Y; 20:6778804-6778804 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.72C>T; p.L24L; 20:6770198-6770198 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.222G>A; p.V74V; 20:6770348-6770348 |
skin | malignant_melanoma | Substitution - coding silent |
c.953C>G; p.P318R; 20:6778851-6778851 |
pancreas | carcinoma | Substitution - Missense |
c.953C>G; p.P318R; 20:6778851-6778851 |
pancreas | carcinoma | Substitution - Missense |
c.966C>T; p.A322A; 20:6778864-6778864 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.501C>G; p.F167L; 20:6778399-6778399 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.980G>A; p.G327E; 20:6778878-6778878 |
breast | carcinoma; HER-positive_carcinoma | Substitution - Missense |
c.463G>T; p.E155*; 20:6778361-6778361 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.979G>A; p.G327R; 20:6778877-6778877 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.376G>A; p.G126R; 20:6778274-6778274 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.1110G>A; p.S370S; 20:6779008-6779008 |
skin | malignant_melanoma | Substitution - coding silent |
c.356A>T; p.E119V; 20:6778254-6778254 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.703G>A; p.E235K; 20:6778601-6778601 |
skin | malignant_melanoma | Substitution - Missense |
c.1077A>G; p.A359A; 20:6778975-6778975 |
lung | carcinoma; small_cell_carcinoma | Substitution - coding silent |
c.684G>T; p.V228V; 20:6778582-6778582 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.673G>A; p.G225R; 20:6778571-6778571 |
skin | malignant_melanoma | Substitution - Missense |
c.772T>C; p.S258P; 20:6778670-6778670 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.754C>T; p.Q252*; 20:6778652-6778652 |
skin | malignant_melanoma | Substitution - Nonsense |
c.124T>G; p.S42A; 20:6770250-6770250 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.434T>C; p.I145T; 20:6778332-6778332 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.778A>G; p.I260V; 20:6778676-6778676 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.633C>T; p.P211P; 20:6778531-6778531 |
skin | malignant_melanoma | Substitution - coding silent |
c.1038G>C; p.Q346H; 20:6778936-6778936 |
skin | malignant_melanoma | Substitution - Missense |
c.292C>T; p.R98W; 20:6770418-6770418 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.891G>C; p.K297N; 20:6778789-6778789 |
breast | carcinoma | Substitution - Missense |
c.623A>G; p.D208G; 20:6778521-6778521 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.679G>A; p.V227M; 20:6778577-6778577 |
skin | malignant_melanoma | Substitution - Missense |
c.416_417insC; p.T141fs*25; 20:6778314-6778315 |
large_intestine; caecum | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.25C>T; p.L9L; 20:6770151-6770151 |
biliary_tract; gallbladder | carcinoma; adenocarcinoma | Substitution - coding silent |
c.25C>T; p.L9L; 20:6770151-6770151 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.949C>T; p.P317S; 20:6778847-6778847 |
skin | malignant_melanoma | Substitution - Missense |
c.949C>T; p.P317S; 20:6778847-6778847 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.866G>A; p.R289Q; 20:6778764-6778764 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1050C>G; p.N350K; 20:6778948-6778948 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.922G>A; p.V308M; 20:6778820-6778820 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.558C>T; p.F186F; 20:6778456-6778456 |
skin | malignant_melanoma | Substitution - coding silent |
c.392G>T; p.R131I; 20:6778290-6778290 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.465A>G; p.E155E; 20:6778363-6778363 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.570A>T; p.R190S; 20:6778468-6778468 |
thyroid | other; neoplasm | Substitution - Missense |
c.756A>G; p.Q252Q; 20:6778654-6778654 |
ovary | carcinoma; serous_carcinoma | Substitution - coding silent |
c.261A>G; p.S87S; 20:6770387-6770387 |
breast | carcinoma | Substitution - coding silent |
c.141C>G; p.D47E; 20:6770267-6770267 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.261A>G; p.S87S; 20:6770387-6770387 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.261A>G; p.S87S; 20:6770387-6770387 |
breast | carcinoma | Substitution - coding silent |
c.389G>A; p.R130Q; 20:6778287-6778287 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.261A>G; p.S87S; 20:6770387-6770387 |
breast | carcinoma | Substitution - coding silent |
c.422C>T; p.T141M; 20:6778320-6778320 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.1132G>A; p.E378K; 20:6779030-6779030 |
skin | malignant_melanoma | Substitution - Missense |
c.1040C>T; p.T347M; 20:6778938-6778938 |
pancreas | carcinoma; ductal_carcinoma | Substitution - Missense |
c.187C>G; p.L63V; 20:6770313-6770313 |
peritoneum; appendix | other; pseudomyxoma_peritonei | Substitution - Missense |
c.93G>A; p.R31R; 20:6770219-6770219 |
skin | malignant_melanoma | Substitution - coding silent |
c.93G>A; p.R31R; 20:6770219-6770219 |
skin | malignant_melanoma | Substitution - coding silent |
c.691G>T; p.A231S; 20:6778589-6778589 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1149G>T; p.K383N; 20:6779047-6779047 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.433A>C; p.I145L; 20:6778331-6778331 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.664G>A; p.A222T; 20:6778562-6778562 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1137G>A; p.K379K; 20:6779035-6779035 |
skin | malignant_melanoma | Substitution - coding silent |