Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

650

Name

BMP2

Synonymous

BDA2|BMP2A;bone morphogenetic protein 2;BMP2;bone morphogenetic protein 2

Definition

BMP-2A|bone morphogenetic protein 2A

Position

20p12

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

BMP2A(h) + Drm(x) <==> BMP2A(h):Drm(x) (binding)
BMP2A(h) + Drm(h) <==> BMP2A(h):Drm(h) (binding)
BMP2A(h) + DAN(m) <==> BMP2A(h):DAN(m) (binding)
BMP2A(h) + Cer1(h) <==> BMP2A(h):Cer1(h) (binding)
BMP2A(h) + BMPR-II(h) + BMPR-IA(h) <==> BMP2A(h):BMPR-IA(h):BMPR-II(h) (binding)
BMP2A(h) + BMPR-IB(m) + BMPR-IA(h) <==> BMP2A(h):BMPR-IA(h):BMPR-IB(m) (binding)
BMP2A(h) + BMPR-IB(m) + BMPR-II(h) <==> BMP2A(h):BMPR-IB(m):BMPR-II(h) (binding)
BMP2A(h) --/ Nodal(c) (transrepression)
BMP2A(h) + chordin(x) <==> BMP2A(h):chordin(x) (binding)
BMP2A(h) + 2 BMPR-IB(m) <==> BMP2A(h):BMPR-IB(m):BMPR-IB(m) (binding)
BMP2A(h) + BMPR-IA(h):BMPR-IA(h) <==> BMP2A(h):BMPR-IA(h):BMPR-IA(h) (binding)
BMP2A(h) + BMPR-IA(h) <==> BMP2A(h):BMPR-IA(h) (binding)
BMP2A(h) + BMPR-II(h) <==> BMP2A(h):BMPR-II(h) (binding)
BMP2A(h) + ActR-II(h) <==> BMP2A(h):ActR-II(h) (binding)
BMP2A(h) + BMPR-IB(h) <==> BMP2A(h):BMPR-IB(h) (binding)
BMP2A(h) --> Smad1(m) (activation; phosphorylation)
BMP2A(h) + noggin(h) <==> BMP2A(h):noggin(h) (binding)
BMP2A(h) --> CDKN1A(h) (transactivation)
BMP2A(h) --> CDKN1B(h) (transactivation)
BMP2A(h) --/ pRb(h) (inhibition)
BMP2A(h) --/ BCL2L1(h) (transrepression)
BMP2A(h) --/ STAT3(h) (transrepression)
BMP2A(h) + Tkv(d) <==> BMP2A(h):Tkv(d) (binding)
BMP2A(h) + Daf-4(ce) + Tkv(d) <==> BMP2A(h):Daf-4(ce):Tkv(d) (binding)
BMP2A(h) --/ Fgf4(m) (transrepression)
BMP2A(h) --> Smad6(r) (increase of abundance)
BMP2(h) --> BMP2A(h) (expression).
BMP2A(h) --> RUNX2(m) (transactivation)
BMP2A(h) --> Zfp64(m) (transactivation)
BMP2A(h) --> Hey1(m) (transactivation)
BMP2(h) --> BMP2A(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

135N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
163N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
164N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
200N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr20

Promoter: 6695245 - 6697245Agilent_014791

chr20

Promoter: 6695245 - 6697245GoldenGate_Methylation_Cancer_Panel_I

chr20

Promoter: 6695245 - 6697245GSE27584

chr20

Promoter: 6695245 - 6697245Agilent_014791_44K

chr20

Promoter: 6695245 - 6697245Agilent_014791

chr20

Promoter: 6695245 - 6697245PMID:16314833

chr20

Promoter: 6695245 - 6697245PMID:15342377


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