| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6776 |
Name | STAT5A |
Synonymous | signal transducer and activator of transcription 5A;STAT5A;signal transducer and activator of transcription 5A |
Definition | - |
Position | 17q11.2 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.15. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.1071C>T; p.G357G; 17:42301356-42301356 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.559G>T; p.A187S; 17:42299759-42299759 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.2377_2378delCT; p.S794fs?; 17:42310661-42310662 |
stomach | carcinoma; intestinal_adenocarcinoma | Deletion - Frameshift |
c.1664G>A; p.W555*; 17:42306431-42306431 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.2018G>A; p.R673H; 17:42308289-42308289 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.2018G>A; p.R673H; 17:42308289-42308289 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.850G>A; p.E284K; 17:42300731-42300731 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.2040C>T; p.S680S; 17:42308311-42308311 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1413C>T; p.H471H; 17:42305642-42305642 |
pancreas | carcinoma | Substitution - coding silent |
c.1413C>T; p.H471H; 17:42305642-42305642 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1170C>T; p.N390N; 17:42304342-42304342 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.819C>T; p.D273D; 17:42300267-42300267 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.271G>A; p.A91T; 17:42290008-42290008 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.271G>A; p.A91T; 17:42290008-42290008 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1096delC; p.Q368fs*2; 17:42301381-42301381 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.1038C>A; p.T346T; 17:42301323-42301323 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.1015C>T; p.P339S; 17:42301300-42301300 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1096delC; p.Q368fs*2; 17:42301381-42301381 |
large_intestine; caecum | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.1038C>A; p.T346T; 17:42301323-42301323 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - coding silent |
c.805G>C; p.E269Q; 17:42300253-42300253 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.805G>C; p.E269Q; 17:42300253-42300253 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.805G>C; p.E269Q; 17:42300253-42300253 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.805G>C; p.E269Q; 17:42300253-42300253 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.805G>C; p.E269Q; 17:42300253-42300253 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.799C>G; p.P267A; 17:42300247-42300247 |
thyroid | other; neoplasm | Substitution - Missense |
c.320G>A; p.R107H; 17:42292006-42292006 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.878T>C; p.I293T; 17:42300759-42300759 |
pancreas | pancreatic_intraepithelial_neoplasia_(PanIN) | Substitution - Missense |
c.1054G>A; p.V352I; 17:42301339-42301339 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1099C>T; p.P367S; 17:42301384-42301384 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.834G>A; p.W278*; 17:42300715-42300715 |
lung | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1694G>A; p.G565D; 17:42307415-42307415 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1492G>A; p.V498M; 17:42306259-42306259 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1363C>T; p.L455F; 17:42304635-42304635 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.2305C>T; p.R769C; 17:42310589-42310589 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1907C>T; p.P636L; 17:42308178-42308178 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1091T>G; p.M364R; 17:42301376-42301376 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.118A>T; p.S40C; 17:42289529-42289529 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1151A>G; p.K384R; 17:42301436-42301436 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1906C>T; p.P636S; 17:42307723-42307723 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.98A>T; p.Y33F; 17:42289509-42289509 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1888G>A; p.A630T; 17:42307705-42307705 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1888G>A; p.A630T; 17:42307705-42307705 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1096C>T; p.P366S; 17:42301381-42301381 |
skin | malignant_melanoma | Substitution - Missense |
c.152C>T; p.P51L; 17:42289889-42289889 |
oesophagus; lower_third | carcinoma; adenocarcinoma | Substitution - Missense |
c.1946G>A; p.R649Q; 17:42308217-42308217 |
breast | carcinoma | Substitution - Missense |
c.1568G>A; p.R523Q; 17:42306335-42306335 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1393C>T; p.P465S; 17:42305622-42305622 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1882A>G; p.T628A; 17:42307699-42307699 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.346G>T; p.E116*; 17:42292032-42292032 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1314G>T; p.E438D; 17:42304586-42304586 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.795_796insG; p.P267fs*14; 17:42300243-42300244 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.1887C>T; p.I629I; 17:42307704-42307704 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma | Substitution - coding silent |
c.2334C>T; p.R778R; 17:42310618-42310618 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1770T>A; p.N590K; 17:42307491-42307491 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1019A>G; p.Q340R; 17:42301304-42301304 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1902C>A; p.D634E; 17:42307719-42307719 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.1657G>A; p.V553M; 17:42306424-42306424 |
breast | carcinoma | Substitution - Missense |
c.1565A>G; p.N522S; 17:42306332-42306332 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.1905C>T; p.S635S; 17:42307722-42307722 |
skin | malignant_melanoma | Substitution - coding silent |
c.1905C>T; p.S635S; 17:42307722-42307722 |
skin | malignant_melanoma | Substitution - coding silent |
c.1007A>G; p.K336R; 17:42301292-42301292 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.1974C>G; p.D658E; 17:42308245-42308245 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.996C>T; p.F332F; 17:42301281-42301281 |
upper_aerodigestive_tract; pharynx | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1203C>T; p.C401C; 17:42304375-42304375 |
breast | carcinoma | Substitution - coding silent |
c.1064T>C; p.L355P; 17:42301349-42301349 |
skin | malignant_melanoma | Substitution - Missense |
c.1064T>C; p.L355P; 17:42301349-42301349 |
skin | malignant_melanoma | Substitution - Missense |
c.2271C>T; p.T757T; 17:42310555-42310555 |
oesophagus; lower_third | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1064T>C; p.L355P; 17:42301349-42301349 |
skin | malignant_melanoma | Substitution - Missense |
c.1303G>A; p.V435M; 17:42304575-42304575 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.2330C>A; p.S777Y; 17:42310614-42310614 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.82A>G; p.I28V; 17:42289493-42289493 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.82A>G; p.I28V; 17:42289493-42289493 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1058G>A; p.R353H; 17:42301343-42301343 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.40G>T; p.A14S; 17:42289451-42289451 |
large_intestine | adenoma | Substitution - Missense |
c.1490C>T; p.A497V; 17:42306257-42306257 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1072G>A; p.G358R; 17:42301357-42301357 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1551C>T; p.A517A; 17:42306318-42306318 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1513C>T; p.P505S; 17:42306280-42306280 |
breast | carcinoma | Substitution - Missense |
c.1126G>T; p.E376*; 17:42301411-42301411 |
breast | carcinoma | Substitution - Nonsense |
c.2034C>T; p.V678V; 17:42308305-42308305 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - coding silent |
c.405C>G; p.D135E; 17:42295648-42295648 |
skin | malignant_melanoma | Substitution - Missense |
c.990-1G>A; p.?; 17:42301274-42301274 |
endometrium | carcinoma; endometrioid_carcinoma | Unknown |
c.1567C>T; p.R523W; 17:42306334-42306334 |
skin | malignant_melanoma | Substitution - Missense |
c.1098C>T; p.P366P; 17:42301383-42301383 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1563C>T; p.S521S; 17:42306330-42306330 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1681G>T; p.E561*; 17:42307402-42307402 |
lung | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1285C>T; p.R429W; 17:42304557-42304557 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.489G>T; p.K163N; 17:42295732-42295732 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.2384G>C; p.*795S; 17:42310668-42310668 |
lung | carcinoma; adenocarcinoma | Nonstop extension |
c.562C>T; p.Q188*; 17:42299762-42299762 |
breast | carcinoma | Substitution - Nonsense |
c.1536C>T; p.N512N; 17:42306303-42306303 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - coding silent |
c.1651C>T; p.L551L; 17:42306418-42306418 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.534G>C; p.E178D; 17:42295777-42295777 |
breast | carcinoma | Substitution - Missense |
c.2048A>C; p.Y683S; 17:42308319-42308319 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.2295G>T; p.E765D; 17:42310579-42310579 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.464C>T; p.T155M; 17:42295707-42295707 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1447C>T; p.L483L; 17:42305676-42305676 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |