Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6776

Name

STAT5A

Synonymous

MGF|STAT5;signal transducer and activator of transcription 5A;STAT5A;signal transducer and activator of transcription 5A

Definition

-

Position

17q11.2

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

c-Kit(h) + STAT5A(h) <==> c-Kit(h):STAT5A(h) (binding)
STAT5A(h) + ATP --c-Kit(h)--> STAT5A(h){pY} + ADP (phosphorylation)
STAT5A(h) + ATP --> STAT5A(h){pY} + ADP (phosphorylation)
4 STAT5A(h) <==> (STAT5A(h))4 (binding)
STAT5A(h) --> CSN2(b) (DNA binding).
SHP-2(h) + STAT5A(h) <==> SHP-2(h):STAT5A(h) (binding)
STAT5A(h) + POU2F1(h) <==> STAT5A(h):POU2F1(h) (binding)
STAT5A(h) --> CCND1(h) (DNA binding; transactivation).
STAT5A(h) --> IFP 53(h) (DNA binding; transactivation).
STAT5A(h) --> IRF1(h) (DNA binding; transactivation).
Btk(h) + STAT5A(h) <==> Btk(h):STAT5A(h) (binding)
Btk(h) + STAT5A(h) <==> Btk(h):STAT5A(h) (binding)
Src(h) + STAT5A(h) <==> Src(h):STAT5A(h) (binding)
ErbB1(h) + STAT5A(h) <==> ErbB1(h):STAT5A(h) (binding)
PECAM-1(h) + STAT5A(h) <==> PECAM-1(h):STAT5A(h) (binding)
STAT5A(h) + brca1(h) <==> STAT5A(h):brca1(h) (binding)
BRCA2(h) + STAT5A(h) <==> BRCA2(h):STAT5A(h) (binding)
2 STAT5A(h) <==> (STAT5A(h))2 (oligomerization)
STAT5B(h) + STAT5A(h) <==> STAT5B(h):STAT5A(h) (oligomerization)
STAT5A(h) --> PIM1(h) (DNA binding).
STAT5A(h) --> CISH(h) (DNA binding).
STAT5A(h) --> WARS2(h) (DNA binding).
MAGE12(h) + STAT5A(h) <==> MAGE12(h):STAT5A(h) (binding)
STAT5A(h) + HHGP(h) <==> STAT5A(h):HHGP(h) (binding)
STAT5A(h) + ATP --> STAT5A(h){p} + ADP (phosphorylation)
STAT5A(h) --> CCL2(h) (transactivation)
STAT5A(h) --> CSN2(h) (DNA binding).
STAT5A(h) + ATP --> STAT5A(h){pY694} + ADP (phosphorylation)
STAT5A(h) --> PRF1(h) (DNA binding).
STAT5A(h) --> FCER2(h) (DNA binding).
STAT5A(h) --> STAT5A(h) (expression).
STAT5A(h) --> A2-Mag(r) (DNA binding).
STAT5A(h) --> FCGR1A(h) (DNA binding).
STAT5A(h) --> IL-2Ralpha(h) (DNA binding; transregulation).
STAT5A(h) --> IL-2Ralpha(m) (DNA binding).
STAT5A(h) --> IGHE(h) (DNA binding).
ErbB2(h){pY1023}{pY1222} + STAT5A(h) <==> ErbB2(h){pY1023}{pY1222}:STAT5A(h) (binding)
ErbB3-isoform1(h) + STAT5A(h) <==> ErbB3-isoform1(h):STAT5A(h) (binding)
STAT5A(h) --> IFNG(h) (DNA binding).
STAT5A(h) + ATP --> STAT5A(h){pY694} + ADP (phosphorylation)
STAT5A(h) --> CISH(h) (DNA binding).
STAT5A(h) --> STAT5A(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

694Phosphotyrosine (by JAK).Swiss-Prot 53.0
780Phosphoserine (By similarity).Swiss-Prot 53.0
694Phosphotyrosine (Lyn;Src;JAK2)11641791;17081983Phospho.ELM 6.0
780Phosphoserine (MAPK1;MAPK3)10194762Phospho.ELM 6.0
90Phosphotyrosine16497976Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr17

Promoter: 37691591 - 37693591GoldenGate_Methylation_Cancer_Panel_I

chr17

Promoter: 37691591 - 37693591GSE27584


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