| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6776 |
Name | STAT5A |
Synonymous | MGF|STAT5;signal transducer and activator of transcription 5A;STAT5A;signal transducer and activator of transcription 5A |
Definition | - |
Position | 17q11.2 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
c-Kit(h) + STAT5A(h) <==> c-Kit(h):STAT5A(h) (binding) | STAT5A(h) + ATP --c-Kit(h)--> STAT5A(h){pY} + ADP (phosphorylation) | STAT5A(h) + ATP --> STAT5A(h){pY} + ADP (phosphorylation) | 4 STAT5A(h) <==> (STAT5A(h))4 (binding) | STAT5A(h) --> CSN2(b) (DNA binding). | SHP-2(h) + STAT5A(h) <==> SHP-2(h):STAT5A(h) (binding) | STAT5A(h) + POU2F1(h) <==> STAT5A(h):POU2F1(h) (binding) | STAT5A(h) --> CCND1(h) (DNA binding; transactivation). | STAT5A(h) --> IFP 53(h) (DNA binding; transactivation). | STAT5A(h) --> IRF1(h) (DNA binding; transactivation). | Btk(h) + STAT5A(h) <==> Btk(h):STAT5A(h) (binding) | Btk(h) + STAT5A(h) <==> Btk(h):STAT5A(h) (binding) | Src(h) + STAT5A(h) <==> Src(h):STAT5A(h) (binding) | ErbB1(h) + STAT5A(h) <==> ErbB1(h):STAT5A(h) (binding) | PECAM-1(h) + STAT5A(h) <==> PECAM-1(h):STAT5A(h) (binding) | STAT5A(h) + brca1(h) <==> STAT5A(h):brca1(h) (binding) | BRCA2(h) + STAT5A(h) <==> BRCA2(h):STAT5A(h) (binding) | 2 STAT5A(h) <==> (STAT5A(h))2 (oligomerization) | STAT5B(h) + STAT5A(h) <==> STAT5B(h):STAT5A(h) (oligomerization) | STAT5A(h) --> PIM1(h) (DNA binding). | STAT5A(h) --> CISH(h) (DNA binding). | STAT5A(h) --> WARS2(h) (DNA binding). | MAGE12(h) + STAT5A(h) <==> MAGE12(h):STAT5A(h) (binding) | STAT5A(h) + HHGP(h) <==> STAT5A(h):HHGP(h) (binding) | STAT5A(h) + ATP --> STAT5A(h){p} + ADP (phosphorylation) | STAT5A(h) --> CCL2(h) (transactivation) | STAT5A(h) --> CSN2(h) (DNA binding). | STAT5A(h) + ATP --> STAT5A(h){pY694} + ADP (phosphorylation) | STAT5A(h) --> PRF1(h) (DNA binding). | STAT5A(h) --> FCER2(h) (DNA binding). | STAT5A(h) --> STAT5A(h) (expression). | STAT5A(h) --> A2-Mag(r) (DNA binding). | STAT5A(h) --> FCGR1A(h) (DNA binding). | STAT5A(h) --> IL-2Ralpha(h) (DNA binding; transregulation). | STAT5A(h) --> IL-2Ralpha(m) (DNA binding). | STAT5A(h) --> IGHE(h) (DNA binding). | ErbB2(h){pY1023}{pY1222} + STAT5A(h) <==> ErbB2(h){pY1023}{pY1222}:STAT5A(h) (binding) | ErbB3-isoform1(h) + STAT5A(h) <==> ErbB3-isoform1(h):STAT5A(h) (binding) | STAT5A(h) --> IFNG(h) (DNA binding). | STAT5A(h) + ATP --> STAT5A(h){pY694} + ADP (phosphorylation) | STAT5A(h) --> CISH(h) (DNA binding). | STAT5A(h) --> STAT5A(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
694 | Phosphotyrosine (by JAK). | Swiss-Prot 53.0 | 780 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 694 | Phosphotyrosine (Lyn;Src;JAK2) | 11641791;17081983 | Phospho.ELM 6.0 | 780 | Phosphoserine (MAPK1;MAPK3) | 10194762 | Phospho.ELM 6.0 | 90 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr17 |
Promoter: 37691591 - 37693591 | GoldenGate_Methylation_Cancer_Panel_I |
chr17 |
Promoter: 37691591 - 37693591 | GSE27584 |