Entrez Gene

Basic Information
Gene ID	6794
Name	STK11
Synonymous	serine/threonine kinase 11;STK11;serine/threonine kinase 11
Definition	liver kinase B1\|polarization-related protein LKB1\|renal carcinoma antigen NY-REN-19\|serine/threonine-protein kinase 11\|serine/threonine-protein kinase LKB1\|serine/threonine-protein kinase STK11
Position	19p13.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.48.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.115C>T; p.R39C; 19:1207028-1207028	liver	carcinoma	Substitution - Missense
c.882G>A; p.P294P; 19:1221968-1221968	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - coding silent
c.2T>C; p.M1T; 19:1206915-1206915	ovary	sex_cord-stromal_tumour; granulosa_cell_tumour	Substitution - Missense
c.910C>T; p.R304W; 19:1221996-1221996	cervix	adenoma_malignum	Substitution - Missense
c.115C>T; p.R39C; 19:1207028-1207028	liver	carcinoma	Substitution - Missense
c.910C>T; p.R304W; 19:1221996-1221996	cervix	carcinoma; adenocarcinoma	Substitution - Missense
c.571A>T; p.K191*; 19:1220479-1220479	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.68delA; p.D23fs*28; 19:1206981-1206981	stomach	carcinoma; diffuse_adenocarcinoma	Deletion - Frameshift
c.597+24_597+38del; p.?; 19:1220529-1220543	cervix	other; lobular_endocervical_glandular_hyperplasia	Unknown
c.587G>T; p.G196V; 19:1220495-1220495	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.157delG; p.D53fs*11; 19:1207070-1207070	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.75_76CA>T; p.I26fs*25; 19:1206988-1206989	lung	carcinoma; adenocarcinoma	Complex - frameshift
c.587G>T; p.G196V; 19:1220495-1220495	skin	malignant_melanoma	Substitution - Missense
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; adenocarcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; adenocarcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; squamous_cell_carcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	lung	carcinoma; adenocarcinoma	Whole gene deletion
c.462C>T; p.H154H; 19:1219411-1219411	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - coding silent
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; squamous_cell_carcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; adenocarcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; adenocarcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	kidney	carcinoma; renal_cell_carcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	kidney	carcinoma; renal_cell_carcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	pancreas	carcinoma; ductal_carcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; squamous_cell_carcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; squamous_cell_carcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; squamous_cell_carcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; squamous_cell_carcinoma	Whole gene deletion
c.318G>T; p.R106R; 19:1218444-1218444	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - coding silent
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; squamous_cell_carcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; squamous_cell_carcinoma	Whole gene deletion
c.1_1302del1302; p.0?; 19:1206914-1226647	cervix	carcinoma; adenocarcinoma	Whole gene deletion
c.879_880insA; p.P294fs*24; 19:1221965-1221966	cervix	carcinoma; adenocarcinoma	Insertion - Frameshift
c.454C>T; p.Q152*; 19:1219403-1219403	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.733C>T; p.L245F; 19:1220716-1220716	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.508C>T; p.Q170*; 19:1220416-1220416	skin	malignant_melanoma	Substitution - Nonsense
c.710A>G; p.D237G; 19:1220693-1220693	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.169delG; p.E57fs*7; 19:1207078-1207078	lung	carcinoma; non_small_cell_carcinoma	Deletion - Frameshift
c.169delG; p.E57fs*7; 19:1207078-1207078	lung	carcinoma; non_small_cell_carcinoma	Deletion - Frameshift
c.508C>T; p.Q170*; 19:1220416-1220416	skin	malignant_melanoma	Substitution - Nonsense
c.508C>T; p.Q170*; 19:1220416-1220416	skin	malignant_melanoma	Substitution - Nonsense
c.169delG; p.E57fs*7; 19:1207078-1207078	lung	carcinoma; non_small_cell_carcinoma	Deletion - Frameshift
c.169delG; p.E57fs*7; 19:1207078-1207078	lung	carcinoma; non_small_cell_carcinoma	Deletion - Frameshift
c.508C>T; p.Q170*; 19:1220416-1220416	skin	malignant_melanoma	Substitution - Nonsense
c.508C>T; p.Q170*; 19:1220416-1220416	skin	malignant_melanoma	Substitution - Nonsense
c.508C>T; p.Q170*; 19:1220416-1220416	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.508C>T; p.Q170*; 19:1220416-1220416	skin	malignant_melanoma	Substitution - Nonsense
c.835_836GG>TT; p.G279F; 19:1221313-1221314	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.169delG; p.E57fs*7; 19:1207078-1207078	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.508C>T; p.Q170*; 19:1220416-1220416	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Nonsense
c.1274G>A; p.R425H; 19:1226619-1226619	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.751G>C; p.G251R; 19:1221229-1221229	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.145T>G; p.Y49D; 19:1207058-1207058	skin	malignant_melanoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	breast	carcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062C>G; p.F354L; 19:1223126-1223126	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.10G>A; p.V4M; 19:1206923-1206923	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.130A>T; p.K44*; 19:1207043-1207043	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.322A>T; p.K108*; 19:1218448-1218448	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1050C>G; p.D350E; 19:1223114-1223114	oesophagus	carcinoma	Substitution - Missense
c.291-1G>T; p.?; 19:1218416-1218416	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.870T>A; p.L290L; 19:1221956-1221956	ovary	sex_cord-stromal_tumour; granulosa_cell_tumour	Substitution - coding silent
c.291-1G>T; p.?; 19:1218416-1218416	lung	carcinoma; adenocarcinoma	Unknown
c.647C>T; p.S216F; 19:1220630-1220630	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.647C>T; p.S216F; 19:1220630-1220630	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.647C>T; p.S216F; 19:1220630-1220630	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.487G>A; p.G163S; 19:1220395-1220395	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.863-2A>T; p.?; 19:1221947-1221947	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.180delC; p.Y60fs*1; 19:1207093-1207093	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.143delA; p.K48fs*3; 19:1207056-1207056	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.180delC; p.Y60fs*1; 19:1207093-1207093	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.863-2A>T; p.?; 19:1221947-1221947	lung	carcinoma; adenocarcinoma	Unknown
c.180delC; p.Y60fs*1; 19:1207093-1207093	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.936delA; p.K312fs*24; 19:1223000-1223000	pancreas	carcinoma; ductal_carcinoma	Deletion - Frameshift
c.291-11_305del26; p.?; 19:1218406-1218431	cervix	carcinoma; squamous_cell_carcinoma	Unknown
c.493G>T; p.E165*; 19:1220401-1220401	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.493G>T; p.E165*; 19:1220401-1220401	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.541A>T; p.N181Y; 19:1220449-1220449	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.598-3C>T; p.?; 19:1220578-1220578	lung	carcinoma; adenocarcinoma	Unknown
c.479T>C; p.L160P; 19:1220387-1220387	cervix	adenoma_malignum	Substitution - Missense
c.597+1G>T; p.?; 19:1220506-1220506	oesophagus	carcinoma; adenocarcinoma	Unknown
c.691T>C; p.F231L; 19:1220674-1220674	cervix	adenoma_malignum	Substitution - Missense
c.597+1G>T; p.?; 19:1220506-1220506	lung	carcinoma; adenocarcinoma	Unknown
c.734+1G>T; p.?; 19:1220718-1220718	lung	carcinoma; adenocarcinoma	Unknown
c.1039_1040insG; p.A347fs*13; 19:1223103-1223104	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.734+1G>T; p.?; 19:1220718-1220718	lung	carcinoma; adenocarcinoma	Unknown
c.526G>C; p.D176H; 19:1220434-1220434	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.734+1G>T; p.?; 19:1220718-1220718	lung	carcinoma; adenocarcinoma	Unknown
c.1100C>T; p.T367M; 19:1223164-1223164	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.260G>A; p.R87K; 19:1207173-1207173	skin	malignant_melanoma	Substitution - Missense
c.260G>A; p.R87K; 19:1207173-1207173	skin	malignant_melanoma	Substitution - Missense
c.979_980insAG; p.D327fs*10; 19:1223043-1223044	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.454C>A; p.Q152K; 19:1219403-1219403	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.628T>C; p.C210R; 19:1220611-1220611	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.707T>C; p.V236A; 19:1220690-1220690	skin	malignant_melanoma	Substitution - Missense
c.630C>A; p.C210*; 19:1220613-1220613	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.42G>A; p.E14E; 19:1206955-1206955	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1105C>T; p.P369S; 19:1223169-1223169	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.595G>C; p.E199Q; 19:1220503-1220503	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.206C>A; p.S69*; 19:1207119-1207119	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.859A>T; p.K287*; 19:1221337-1221337	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1137C>A; p.H379Q; 19:1226482-1226482	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.206C>A; p.S69*; 19:1207119-1207119	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.180C>A; p.Y60*; 19:1207093-1207093	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.290+2T>G; p.?; 19:1207205-1207205	lung	carcinoma; adenocarcinoma	Unknown
c.1049A>G; p.D350G; 19:1223113-1223113	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.232A>G; p.K78E; 19:1207145-1207145	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1240G>A; p.A414T; 19:1226585-1226585	pancreas	carcinoma	Substitution - Missense
c.232A>G; p.K78E; 19:1207145-1207145	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.367C>T; p.Q123*; 19:1218493-1218493	breast	carcinoma	Substitution - Nonsense
c.396C>A; p.C132*; 19:1219345-1219345	liver	carcinoma	Substitution - Nonsense
c.367C>T; p.Q123*; 19:1218493-1218493	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.535C>T; p.P179S; 19:1220443-1220443	prostate	carcinoma	Substitution - Missense
c.703A>T; p.K235*; 19:1220686-1220686	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.621C>G; p.D207E; 19:1220604-1220604	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.579delC; p.D194fs*93; 19:1220487-1220487	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.209delA; p.E70fs*26; 19:1207122-1207122	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.426C>T; p.S142S; 19:1219375-1219375	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.411G>A; p.Q137Q; 19:1219360-1219360	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1168G>A; p.V390M; 19:1226513-1226513	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.465-1G>T; p.?; 19:1220372-1220372	lung	carcinoma; adenocarcinoma	Unknown
c.908T>G; p.I303S; 19:1221994-1221994	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.465-1G>T; p.?; 19:1220372-1220372	lung	carcinoma; adenocarcinoma	Unknown
c.291-2A>T; p.?; 19:1218415-1218415	lung	carcinoma; adenocarcinoma	Unknown
c.598-1G>T; p.?; 19:1220580-1220580	lung	carcinoma; adenocarcinoma	Unknown
c.291-2A>T; p.?; 19:1218415-1218415	lung	carcinoma; adenocarcinoma	Unknown
c.57G>T; p.S19S; 19:1206970-1206970	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.357C>T; p.N119N; 19:1218483-1218483	skin	malignant_melanoma	Substitution - coding silent
c.522C>T; p.H174H; 19:1220430-1220430	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.522C>T; p.H174H; 19:1220430-1220430	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.583C>A; p.L195M; 19:1220491-1220491	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.921-1G>T; p.?; 19:1222984-1222984	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.920+1G>C; p.?; 19:1222007-1222007	oesophagus	carcinoma; adenocarcinoma	Unknown
c.358G>T; p.E120*; 19:1218484-1218484	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.149T>G; p.L50R; 19:1207062-1207062	soft_tissue; fibrous_tissue_and_uncertain_o	alveolar_soft_part_sarcoma	Substitution - Missense
c.358G>T; p.E120*; 19:1218484-1218484	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.228delC; p.V77fs*19; 19:1207141-1207141	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.358G>T; p.E120*; 19:1218484-1218484	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.455A>G; p.Q152R; 19:1219404-1219404	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.455A>G; p.Q152R; 19:1219404-1219404	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.120_130del11; p.K41fs*118; 19:1207033-1207043	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.455A>G; p.Q152R; 19:1219404-1219404	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.411_412GG>TT; p.Q137_E138>H*; 19:1219360-1219361	lung	carcinoma; adenocarcinoma	Complex - compound substitution
c.318G>A; p.R106R; 19:1218444-1218444	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.735-1G>T; p.?; 19:1221212-1221212	lung	carcinoma; adenocarcinoma	Unknown
c.735-1G>T; p.?; 19:1221212-1221212	lung	carcinoma; adenocarcinoma	Unknown
c.579_580CG>AT; p.D194Y; 19:1220487-1220488	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.735-1G>T; p.?; 19:1221212-1221212	lung	carcinoma; adenocarcinoma	Unknown
c.735-1G>T; p.?; 19:1221212-1221212	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.290+2T>A; p.?; 19:1207205-1207205	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.511G>A; p.G171S; 19:1220419-1220419	large_intestine; colon	adenoma	Substitution - Missense
c.511G>A; p.G171S; 19:1220419-1220419	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.829G>T; p.D277Y; 19:1221307-1221307	lung	carcinoma; mixed_adenosquamous_carcinoma	Substitution - Missense
c.179A>G; p.Y60C; 19:1207092-1207092	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.465_597del133; p.Y156fs*87; 19:1220373-1220505	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.465_597del133; p.Y156fs*87; 19:1220373-1220505	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.465_597del133; p.Y156fs*87; 19:1220373-1220505	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.465_597del133; p.Y156fs*87; 19:1220373-1220505	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.181delG; p.G61fs*3; 19:1207094-1207094	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.465-2A>T; p.?; 19:1220371-1220371	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.474T>G; p.C158W; 19:1220382-1220382	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.598-2A>T; p.?; 19:1220579-1220579	lung	carcinoma; adenocarcinoma	Unknown
c.137T>C; p.I46T; 19:1207050-1207050	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.862+1G>T; p.?; 19:1221341-1221341	lung	carcinoma; adenocarcinoma	Unknown
c.1_378del378; p.?; 19:1206914-1220460	skin; penis	carcinoma; squamous_cell_carcinoma	Unknown
c.784A>T; p.K262*; 19:1221262-1221262	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1_378del378; p.?; 19:1206914-1220460	skin; penis	carcinoma; squamous_cell_carcinoma	Unknown
c.233A>G; p.K78R; 19:1207146-1207146	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.503A>G; p.H168R; 19:1220411-1220411	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.110A>T; p.Q37L; 19:1207023-1207023	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.137T>C; p.I46T; 19:1207050-1207050	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1_378del378; p.?; 19:1206914-1220460	skin; penis	carcinoma; squamous_cell_carcinoma	Unknown
c.126_149del24; p.A43_L50del; 19:1207039-1207062	lung	carcinoma; adenocarcinoma	Deletion - In frame
c.264C>A; p.I88I; 19:1207177-1207177	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.910C>G; p.R304G; 19:1221996-1221996	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.910C>G; p.R304G; 19:1221996-1221996	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.735-2A>T; p.?; 19:1221211-1221211	lung	carcinoma; adenocarcinoma	Unknown
c.941C>A; p.P314H; 19:1223005-1223005	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.256C>G; p.R86G; 19:1207169-1207169	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.509_509delA; p.Q170fs*117; 19:1220417-1220417	cervix	other; lobular_endocervical_glandular_hyperplasia	Deletion - Frameshift
c.941C>A; p.P314H; 19:1223005-1223005	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.921-1G>A; p.?; 19:1222984-1222984	lung	carcinoma; adenocarcinoma	Unknown
c.109C>A; p.Q37K; 19:1207022-1207022	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.520C>T; p.H174Y; 19:1220428-1220428	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.407_408TG>AT; p.M136N; 19:1219356-1219357	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.837delC; p.P281fs*6; 19:1221315-1221315	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.465-2A>G; p.?; 19:1220371-1220371	cervix	carcinoma; endocervical_adenocarcinoma	Unknown
c.178_179insA; p.Y60fs*1; 19:1207091-1207092	breast	carcinoma	Insertion - Frameshift
c.837delC; p.P281fs*6; 19:1221315-1221315	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.589G>A; p.V197M; 19:1220497-1220497	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.260G>T; p.R87M; 19:1207173-1207173	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1008_1009delTG; p.V337fs*22; 19:1223072-1223073	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.646T>C; p.S216P; 19:1220629-1220629	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.167_168insTTCC; p.E57fs*107; 19:1207080-1207081	breast	carcinoma	Insertion - Frameshift
c.152_153insG; p.D53fs*110; 19:1207065-1207066	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.368A>G; p.Q123R; 19:1218494-1218494	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.524A>T; p.K175M; 19:1220432-1220432	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.709G>T; p.D237Y; 19:1220692-1220692	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.544_546delCTG; p.L182del; 19:1220452-1220454	lung	carcinoma; adenocarcinoma	Deletion - In frame
c.658C>T; p.Q220*; 19:1220641-1220641	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.167G>T; p.G56V; 19:1207080-1207080	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.658C>T; p.Q220*; 19:1220641-1220641	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.658C>T; p.Q220*; 19:1220641-1220641	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.658C>T; p.Q220*; 19:1220641-1220641	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.644G>A; p.G215D; 19:1220627-1220627	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.184A>T; p.K62*; 19:1207097-1207097	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.205T>C; p.S69P; 19:1207118-1207118	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.921-10G>A; p.?; 19:1222975-1222975	cervix	adenoma_malignum	Unknown
c.1276C>T; p.R426W; 19:1226621-1226621	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.184A>T; p.K62*; 19:1207097-1207097	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.536C>T; p.P179L; 19:1220444-1220444	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1A>G; p.M1V; 19:1206914-1206914	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.532A>T; p.K178*; 19:1220440-1220440	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Nonsense
c.810delG; p.S271fs*16; 19:1221288-1221288	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.765_766CG>TT; p.F255>?; 19:1221243-1221244	lung	carcinoma; adenocarcinoma	Complex
c.528C>T; p.D176D; 19:1220436-1220436	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.465_862del398; p.?; 19:1220373-1221340	lung	carcinoma; non_small_cell_carcinoma	Unknown
c.465_862del398; p.?; 19:1220373-1221340	lung	carcinoma; non_small_cell_carcinoma	Unknown
c.127_128insGG; p.A43fs*9; 19:1207040-1207041	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.148_159del12; p.L50_D53del; 19:1207061-1207072	lung	carcinoma; adenocarcinoma	Deletion - In frame
c.814T>C; p.Y272H; 19:1221292-1221292	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.787_790delTTGT; p.F264fs*22; 19:1221265-1221268	gastrointestinal_tract_(site_indeterminate)	other; hamartoma	Deletion - Frameshift
c.787_790delTTGT; p.F264fs*22; 19:1221265-1221268	gastrointestinal_tract_(site_indeterminate)	other; hamartoma	Deletion - Frameshift
c.787_790delTTGT; p.F264fs*22; 19:1221265-1221268	gastrointestinal_tract_(site_indeterminate)	other; hamartoma	Deletion - Frameshift
c.787_790delTTGT; p.F264fs*22; 19:1221265-1221268	gastrointestinal_tract_(site_indeterminate)	other; hamartoma	Deletion - Frameshift
c.996G>A; p.W332*; 19:1223060-1223060	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.996G>A; p.W332*; 19:1223060-1223060	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.165_166insT; p.G56fs*107; 19:1207078-1207079	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1198C>T; p.L400L; 19:1226543-1226543	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.735_862del128; p.Y246fs*3; 19:1221213-1221340	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.129delC; p.K44fs*7; 19:1207042-1207042	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.527A>C; p.D176A; 19:1220435-1220435	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.180C>T; p.Y60Y; 19:1207093-1207093	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.409C>T; p.Q137*; 19:1219358-1219358	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.170A>G; p.E57G; 19:1207083-1207083	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.180C>T; p.Y60Y; 19:1207093-1207093	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.650_651insC; p.A218fs*48; 19:1220633-1220634	gastrointestinal_tract_(site_indeterminate)	other; hamartoma	Insertion - Frameshift
c.613G>A; p.A205T; 19:1220596-1220596	upper_aerodigestive_tract; sinonasal_and_nasal_cavity	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.171A>G; p.E57E; 19:1207084-1207084	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.724G>C; p.G242R; 19:1220707-1220707	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.622G>A; p.D208N; 19:1220605-1220605	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.333C>T; p.I111I; 19:1218459-1218459	skin	malignant_melanoma	Substitution - coding silent
c.1208A>T; p.K403I; 19:1226553-1226553	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.256C>A; p.R86R; 19:1207169-1207169	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.735-2A>G; p.?; 19:1221211-1221211	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.735-2A>G; p.?; 19:1221211-1221211	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.735-2A>G; p.?; 19:1221211-1221211	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.735-2A>G; p.?; 19:1221211-1221211	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.735-2A>G; p.?; 19:1221211-1221211	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.957_958AG>T; p.V320fs*16; 19:1223021-1223022	cervix	carcinoma; adenocarcinoma	Complex - frameshift
c.1190C>T; p.A397V; 19:1226535-1226535	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.648C>T; p.S216S; 19:1220631-1220631	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1190C>T; p.A397V; 19:1226535-1226535	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.667G>T; p.E223*; 19:1220650-1220650	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.667G>T; p.E223*; 19:1220650-1220650	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.945G>A; p.P315P; 19:1223009-1223009	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1167C>T; p.A389A; 19:1226512-1226512	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.657C>T; p.F219F; 19:1220640-1220640	breast	carcinoma; HER-positive_carcinoma	Substitution - coding silent
c.97G>T; p.E33*; 19:1207010-1207010	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1117C>T; p.P373S; 19:1226462-1226462	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.196G>A; p.V66M; 19:1207109-1207109	cervix	adenoma_malignum	Substitution - Missense
c.196G>A; p.V66M; 19:1207109-1207109	cervix	adenoma_malignum	Substitution - Missense
c.145T>C; p.Y49H; 19:1207058-1207058	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.725G>T; p.G242V; 19:1220708-1220708	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.97G>T; p.E33*; 19:1207010-1207010	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.827delG; p.G276fs*11; 19:1221305-1221305	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.751_752GG>TT; p.G251F; 19:1221229-1221230	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.334C>T; p.Q112*; 19:1218460-1218460	skin	malignant_melanoma	Substitution - Nonsense
c.168G>T; p.G56G; 19:1207081-1207081	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.45C>T; p.G15G; 19:1206958-1206958	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.475C>T; p.Q159*; 19:1220383-1220383	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.475C>T; p.Q159*; 19:1220383-1220383	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.530T>C; p.I177T; 19:1220438-1220438	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.475C>T; p.Q159*; 19:1220383-1220383	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.403G>C; p.G135R; 19:1219352-1219352	skin	malignant_melanoma	Substitution - Missense
c.891G>C; p.R297S; 19:1221977-1221977	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.610_623del14; p.F204fs*57; 19:1220593-1220606	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.563delG; p.G188fs*99; 19:1220471-1220471	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.250A>T; p.K84*; 19:1207163-1207163	pancreas	carcinoma	Substitution - Nonsense
c.194A>G; p.E65G; 19:1207107-1207107	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.752G>T; p.G251V; 19:1221230-1221230	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.166G>T; p.G56W; 19:1207079-1207079	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.166G>T; p.G56W; 19:1207079-1207079	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.166_178del13; p.G56fs*4; 19:1207079-1207091	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.584_585insT; p.V197fs*69; 19:1220492-1220493	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.802delG; p.K269fs*18; 19:1221280-1221280	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.894C>A; p.F298L; 19:1221980-1221980	cervix	carcinoma; adenocarcinoma	Substitution - Missense
c.581A>T; p.D194V; 19:1220489-1220489	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.802G>A; p.G268R; 19:1221280-1221280	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.649_650insG; p.P217fs*49; 19:1220632-1220633	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Insertion - Frameshift
c.465-1G>A; p.?; 19:1220372-1220372	lung	carcinoma; adenocarcinoma	Unknown
c.431delC; p.P144fs*17; 19:1219380-1219380	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.379-5C>G; p.?; 19:1219323-1219323	stomach	carcinoma; adenocarcinoma	Unknown
c.40G>A; p.E14K; 19:1206953-1206953	cervix	adenoma_malignum	Substitution - Missense
c.595G>T; p.E199*; 19:1220503-1220503	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.206C>T; p.S69L; 19:1207119-1207119	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.595G>T; p.E199*; 19:1220503-1220503	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.842C>T; p.P281L; 19:1221320-1221320	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.842C>T; p.P281L; 19:1221320-1221320	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.842C>T; p.P281L; 19:1221320-1221320	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.842C>T; p.P281L; 19:1221320-1221320	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.842C>T; p.P281L; 19:1221320-1221320	large_intestine; rectum	adenoma	Substitution - Missense
c.842C>T; p.P281L; 19:1221320-1221320	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.842C>T; p.P281L; 19:1221320-1221320	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.842C>T; p.P281L; 19:1221320-1221320	ovary	carcinoma; clear_cell_carcinoma	Substitution - Missense
c.842C>T; p.P281L; 19:1221320-1221320	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.842C>T; p.P281L; 19:1221320-1221320	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.432_433GG>TT; p.P144>?; 19:1219381-1219382	lung	carcinoma; adenocarcinoma	Complex
c.842C>T; p.P281L; 19:1221320-1221320	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.580G>T; p.D194Y; 19:1220488-1220488	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.580G>T; p.D194Y; 19:1220488-1220488	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.580G>T; p.D194Y; 19:1220488-1220488	skin	malignant_melanoma	Substitution - Missense
c.580G>T; p.D194Y; 19:1220488-1220488	skin	malignant_melanoma	Substitution - Missense
c.724G>T; p.G242W; 19:1220707-1220707	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.580G>T; p.D194Y; 19:1220488-1220488	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.580G>T; p.D194Y; 19:1220488-1220488	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.580G>T; p.D194Y; 19:1220488-1220488	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.842delC; p.P281fs*6; 19:1221320-1221320	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.842delC; p.P281fs*6; 19:1221320-1221320	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.842delC; p.P281fs*6; 19:1221320-1221320	lung	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.842delC; p.P281fs*6; 19:1221320-1221320	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.842delC; p.P281fs*6; 19:1221320-1221320	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.842delC; p.P281fs*6; 19:1221320-1221320	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.842delC; p.P281fs*6; 19:1221320-1221320	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.957A>G; p.P319P; 19:1223021-1223021	large_intestine; rectum	NS	Substitution - coding silent
c.908T>A; p.I303N; 19:1221994-1221994	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.539G>T; p.G180V; 19:1220447-1220447	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1050C>T; p.D350D; 19:1223114-1223114	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1050C>T; p.D350D; 19:1223114-1223114	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - coding silent
c.578C>T; p.S193F; 19:1220486-1220486	skin	malignant_melanoma	Substitution - Missense
c.108C>A; p.Y36*; 19:1207021-1207021	pancreas	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.1041G>A; p.A347A; 19:1223105-1223105	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1165G>A; p.A389T; 19:1226510-1226510	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.109C>T; p.Q37*; 19:1207022-1207022	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.109C>T; p.Q37*; 19:1207022-1207022	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.109C>T; p.Q37*; 19:1207022-1207022	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.109C>T; p.Q37*; 19:1207022-1207022	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.258A>G; p.R86R; 19:1207171-1207171	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.109C>T; p.Q37*; 19:1207022-1207022	lung	carcinoma; large_cell_carcinoma	Substitution - Nonsense
c.109C>T; p.Q37*; 19:1207022-1207022	lung	carcinoma; large_cell_carcinoma	Substitution - Nonsense
c.109C>T; p.Q37*; 19:1207022-1207022	lung	carcinoma; large_cell_carcinoma	Substitution - Nonsense
c.109C>T; p.Q37*; 19:1207022-1207022	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.643_645GGC>AGT; p.G215S; 19:1220626-1220628	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.109C>T; p.Q37*; 19:1207022-1207022	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Nonsense
c.109C>T; p.Q37*; 19:1207022-1207022	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Nonsense
c.109C>T; p.Q37*; 19:1207022-1207022	stomach	carcinoma	Substitution - Nonsense
c.109C>T; p.Q37*; 19:1207022-1207022	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.109C>T; p.Q37*; 19:1207022-1207022	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.165delG; p.E57fs*7; 19:1207078-1207078	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1090C>T; p.Q364*; 19:1223154-1223154	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.580G>A; p.D194N; 19:1220488-1220488	small_intestine; duodenum	carcinoma; adenocarcinoma	Substitution - Missense
c.597G>C; p.E199D; 19:1220505-1220505	pancreas	other; dysplasia-in_situ_neoplasm	Substitution - Missense
c.597G>C; p.E199D; 19:1220505-1220505	pancreas	other; dysplasia-in_situ_neoplasm	Substitution - Missense
c.580G>A; p.D194N; 19:1220488-1220488	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.153delG; p.D53fs*11; 19:1207066-1207066	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.153delG; p.D53fs*11; 19:1207066-1207066	lung	carcinoma; large_cell_carcinoma	Deletion - Frameshift
c.984C>T; p.T328T; 19:1223048-1223048	skin	malignant_melanoma	Substitution - coding silent
c.793G>T; p.E265*; 19:1221271-1221271	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.598-1G>A; p.?; 19:1220580-1220580	lung	carcinoma; adenocarcinoma	Unknown
c.598-1G>A; p.?; 19:1220580-1220580	lung	carcinoma; adenocarcinoma	Unknown
c.971C>T; p.P324L; 19:1223035-1223035	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.436A>T; p.K146*; 19:1219385-1219385	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.271_272GG>TT; p.G91L; 19:1207184-1207185	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.56C>A; p.S19*; 19:1206969-1206969	cervix	carcinoma; mixed_adenosquamous_carcinoma	Substitution - Nonsense
c.1048G>A; p.D350N; 19:1223112-1223112	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.102C>T; p.V34V; 19:1207015-1207015	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - coding silent
c.224G>T; p.R75M; 19:1207137-1207137	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.608C>T; p.P203L; 19:1220591-1220591	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.654T>C; p.A218A; 19:1220637-1220637	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.521A>G; p.H174R; 19:1220429-1220429	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1257C>T; p.S419S; 19:1226602-1226602	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.923G>T; p.W308L; 19:1222987-1222987	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.208G>A; p.E70K; 19:1207121-1207121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.889A>G; p.R297G; 19:1221975-1221975	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.264C>G; p.I88M; 19:1207177-1207177	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.274G>A; p.E92K; 19:1207187-1207187	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.396C>T; p.C132C; 19:1219345-1219345	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.842_843insC; p.L282fs*3; 19:1221320-1221321	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.842_843insC; p.L282fs*3; 19:1221320-1221321	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.17C>A; p.P6Q; 19:1206930-1206930	cervix	carcinoma; mixed_adenosquamous_carcinoma	Substitution - Missense
c.842_843insC; p.L282fs*3; 19:1221320-1221321	lung	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.526G>T; p.D176Y; 19:1220434-1220434	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.717G>T; p.W239C; 19:1220700-1220700	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.509A>G; p.Q170R; 19:1220417-1220417	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.717G>T; p.W239C; 19:1220700-1220700	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.509A>G; p.Q170R; 19:1220417-1220417	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.488G>A; p.G163D; 19:1220396-1220396	testis	germ_cell_tumour; mixed	Substitution - Missense
c.717G>T; p.W239C; 19:1220700-1220700	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.595G>A; p.E199K; 19:1220503-1220503	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.208G>T; p.E70*; 19:1207121-1207121	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.208G>T; p.E70*; 19:1207121-1207121	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.542A>T; p.N181I; 19:1220450-1220450	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.208G>T; p.E70*; 19:1207121-1207121	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.180C>G; p.Y60*; 19:1207093-1207093	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.598-13del22; p.?; 19:1220568-1220589	lung	carcinoma; adenocarcinoma	Unknown
c.816C>T; p.Y272Y; 19:1221294-1221294	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.816C>T; p.Y272Y; 19:1221294-1221294	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.816C>T; p.Y272Y; 19:1221294-1221294	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.816C>T; p.Y272Y; 19:1221294-1221294	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.709_709delG; p.D237fs*50; 19:1220692-1220692	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.650delC; p.P217fs*70; 19:1220633-1220633	pancreas	carcinoma; ductal_carcinoma	Deletion - Frameshift
c.193G>T; p.E65*; 19:1207106-1207106	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.650delC; p.P217fs*70; 19:1220633-1220633	pancreas	other; dysplasia-in_situ_neoplasm	Deletion - Frameshift
c.1225C>T; p.R409W; 19:1226570-1226570	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1193C>T; p.A398V; 19:1226538-1226538	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.169G>T; p.E57*; 19:1207082-1207082	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.513C>T; p.G171G; 19:1220421-1220421	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - coding silent
c.662C>T; p.P221L; 19:1220645-1220645	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.256C>T; p.R86*; 19:1207169-1207169	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Nonsense
c.96C>G; p.T32T; 19:1207009-1207009	cervix	adenoma_malignum	Substitution - coding silent
c.96C>G; p.T32T; 19:1207009-1207009	small_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.128delC; p.K44fs*7; 19:1207041-1207041	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1226G>A; p.R409Q; 19:1226571-1226571	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.487G>T; p.G163C; 19:1220395-1220395	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1226G>A; p.R409Q; 19:1226571-1226571	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1226G>A; p.R409Q; 19:1226571-1226571	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1226G>A; p.R409Q; 19:1226571-1226571	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1226G>A; p.R409Q; 19:1226571-1226571	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1226G>A; p.R409Q; 19:1226571-1226571	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.320A>G; p.H107R; 19:1218446-1218446	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]