| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 6794 |
Name | STK11 |
Synonymous | LKB1|PJS|hLKB1;serine/threonine kinase 11;STK11;serine/threonine kinase 11 |
Definition | liver kinase B1|polarization-related protein LKB1|renal carcinoma antigen NY-REN-19|serine/threonine-protein kinase 11|serine/threonine-protein kinase LKB1|serine/threonine-protein kinase STK11 |
Position | 19p13.3 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
|
Regulation From TransFac database |
LKB1(h) + STRADalpha(h) + MO25(h) <==> LKB1(h):STRADalpha(h):MO25(h) (binding) | BRG1(h) + LKB1(h) <==> BRG1(h):LKB1(h) (binding) | p53(h) + LKB1(h) <==> p53(h):LKB1(h) (binding) | LKB1(h) + ABIN-2(h) <==> LKB1(h):ABIN-2(h) (binding) | LKB1(h) + STRADalpha(h) <==> LKB1(h):STRADalpha(h) (binding) | LKB1(h) + ATP --> LKB1(h){pS428} + ADP (phosphorylation) | LKB1(h) --> AMPKalpha-2(h){pT172} (increase of phosphorylation) | STK11(h) --> LKB1(h) (expression). | LKB1(h) + MO25(h) <==> LKB1(h):MO25(h) (binding) | STRADalpha(h) + LKB1(h) <==> STRADalpha(h):LKB1(h) (binding) | LKB1(h) + ATP --> LKB1(h){pS428} + ADP (phosphorylation) | STK11(h) --> LKB1(h) (expression). | p65PAK(m.s.) + ATP --LKB1(h)--> p65PAK(m.s.){pT109} + ADP (phosphorylation) |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
31 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 336 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 | 363 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 | 428 | Phosphoserine (by PKA) (Potential). | Swiss-Prot 53.0 | 363 | Phosphothreonine (ATM) | 12234250 | Phospho.ELM 6.0 | 189 | Phosphothreonine (LKB1) | 11430832 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr19 |
Promoter: 1155298 - 1157298 | Agilent_014791 |
chr19 |
Promoter: 1155298 - 1157298 | GoldenGate_Methylation_Cancer_Panel_I |
chr19 |
Promoter: 1155298 - 1157298 | GSE27584 |
chr19 |
Promoter: 1155298 - 1157298 | Agilent_014791_44K |
chr19 |
Promoter: 1155298 - 1157298 | PMID:10644993 |
chr19 |
Promoter: 1155298 - 1157298 | PMID:15389252 |
chr19 |
Promoter: 1155298 - 1157298 | PMID:10896921 |