| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 688 |
Name | KLF5 |
Synonymous | Kruppel-like factor 5 (intestinal);KLF5;Kruppel-like factor 5 (intestinal) |
Definition | BTE-binding protein 2|GC box binding protein 2|Klf5C isoform|Krueppel-like factor 5|basic transcription element binding protein 2|colon krueppel-like factor|colon kruppel-like factor|intestinal-enriched krueppel-like factor|intestinal-enriched kruppel-lik |
Position | 13q22.1 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.04. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.1053A>T; p.S351S; 13:73062652-73062652 |
biliary_tract; gallbladder | carcinoma; adenocarcinoma | Substitution - coding silent |
c.914C>G; p.P305R; 13:73062513-73062513 |
upper_aerodigestive_tract; mouth | carcinoma | Substitution - Missense |
c.914C>G; p.P305R; 13:73062513-73062513 |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1255G>C; p.E419Q; 13:73075767-73075767 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1255G>C; p.E419Q; 13:73075767-73075767 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1255G>C; p.E419Q; 13:73075767-73075767 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1158G>C; p.K386N; 13:73063846-73063846 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - Missense |
c.1255G>C; p.E419Q; 13:73075767-73075767 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.1158G>C; p.K386N; 13:73063846-73063846 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.1255G>C; p.E419Q; 13:73075767-73075767 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1242C>T; p.F414F; 13:73075754-73075754 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1242C>T; p.F414F; 13:73075754-73075754 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.1255G>A; p.E419K; 13:73075767-73075767 |
lung; middle_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.903C>T; p.P301P; 13:73062502-73062502 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.586C>A; p.H196N; 13:73062185-73062185 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1085_1100del16; p.S363fs*23; 13:73062684-73062699 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Deletion - Frameshift |
c.672G>C; p.Q224H; 13:73062271-73062271 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1185G>T; p.R395S; 13:73063873-73063873 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.462G>T; p.Q154H; 13:73062061-73062061 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.539C>T; p.P180L; 13:73062138-73062138 |
kidney | carcinoma; papillary_renal_cell_carcinoma | Substitution - Missense |
c.1210A>G; p.K404E; 13:73075722-73075722 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.593C>T; p.T198I; 13:73062192-73062192 |
skin | malignant_melanoma | Substitution - Missense |
c.1261A>C; p.T421P; 13:73075773-73075773 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1261A>C; p.T421P; 13:73075773-73075773 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1261A>C; p.T421P; 13:73075773-73075773 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1261A>C; p.T421P; 13:73075773-73075773 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1288G>A; p.A430T; 13:73075800-73075800 |
kidney | other; neoplasm | Substitution - Missense |
c.324G>A; p.E108E; 13:73061923-73061923 |
oesophagus | carcinoma; adenocarcinoma | Substitution - coding silent |
c.901C>T; p.P301S; 13:73062500-73062500 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.901C>T; p.P301S; 13:73062500-73062500 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.483C>G; p.I161M; 13:73062082-73062082 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.902C>A; p.P301H; 13:73062501-73062501 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1253A>G; p.D418G; 13:73075765-73075765 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.398G>T; p.S133I; 13:73061997-73061997 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.307G>A; p.V103I; 13:73061906-73061906 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.369C>T; p.F123F; 13:73061968-73061968 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.897C>T; p.Y299Y; 13:73062496-73062496 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.499G>A; p.A167T; 13:73062098-73062098 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.841A>G; p.M281V; 13:73062440-73062440 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.941G>A; p.R314K; 13:73062540-73062540 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.932G>T; p.S311I; 13:73062531-73062531 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.932G>T; p.S311I; 13:73062531-73062531 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.929_931delGAA; p.S311delS; 13:73062528-73062530 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - In frame |
c.1192A>G; p.T398A; 13:73063880-73063880 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.655C>T; p.L219F; 13:73062254-73062254 |
breast | carcinoma | Substitution - Missense |
c.350C>T; p.A117V; 13:73061949-73061949 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.896_897insA; p.Y299fs*1; 13:73062495-73062496 |
biliary_tract; gallbladder | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.545C>T; p.P182L; 13:73062144-73062144 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1250C>T; p.S417L; 13:73075762-73075762 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.492A>C; p.E164D; 13:73062091-73062091 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.958C>T; p.Q320*; 13:73062557-73062557 |
skin | malignant_melanoma | Substitution - Nonsense |
c.845C>T; p.P282L; 13:73062444-73062444 |
skin | malignant_melanoma | Substitution - Missense |
c.781G>A; p.A261T; 13:73062380-73062380 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.907T>C; p.S303P; 13:73062506-73062506 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.595G>A; p.A199T; 13:73062194-73062194 |
central_nervous_system; brain | glioma | Substitution - Missense |
c.911C>T; p.P304L; 13:73062510-73062510 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.725C>G; p.S242C; 13:73062324-73062324 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1253A>T; p.D418V; 13:73075765-73075765 |
salivary_gland; parotid | carcinoma; adenoid_cystic_carcinoma | Substitution - Missense |
c.523A>G; p.T175A; 13:73062122-73062122 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.420C>T; p.L140L; 13:73062019-73062019 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.953T>G; p.M318R; 13:73062552-73062552 |
liver | carcinoma | Substitution - Missense |
c.919T>G; p.S307A; 13:73062518-73062518 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.953T>G; p.M318R; 13:73062552-73062552 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.1024A>T; p.N342Y; 13:73062623-73062623 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.843G>A; p.M281I; 13:73062442-73062442 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.317T>G; p.I106S; 13:73061916-73061916 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1198G>A; p.E400K; 13:73075710-73075710 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.1198G>A; p.E400K; 13:73075710-73075710 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - Missense |
c.1163_1165delCTC; p.S388_H389>Y; 13:73063851-73063853 |
large_intestine | carcinoma; adenocarcinoma | Complex - deletion inframe |
c.812C>T; p.P271L; 13:73062411-73062411 |
breast | carcinoma | Substitution - Missense |
c.28G>A; p.A10T; 13:73059355-73059355 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.28G>A; p.A10T; 13:73059355-73059355 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.764C>T; p.S255F; 13:73062363-73062363 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.905C>A; p.P302Q; 13:73062504-73062504 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.941G>C; p.R314T; 13:73062540-73062540 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.443C>A; p.T148N; 13:73062042-73062042 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.846C>T; p.P282P; 13:73062445-73062445 |
liver | carcinoma | Substitution - coding silent |
c.443C>A; p.T148N; 13:73062042-73062042 |
skin | malignant_melanoma | Substitution - Missense |
c.261+3A>C; p.?; 13:73059591-73059591 |
oesophagus | carcinoma; adenocarcinoma | Unknown |
c.1252G>T; p.D418Y; 13:73075764-73075764 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1081_1083delAGA; p.R362delR; 13:73062680-73062682 |
stomach | carcinoma; intestinal_adenocarcinoma | Deletion - In frame |
c.902C>T; p.P301L; 13:73062501-73062501 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.902C>T; p.P301L; 13:73062501-73062501 |
skin; neck | malignant_melanoma | Substitution - Missense |
c.853A>G; p.T285A; 13:73062452-73062452 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma | Substitution - Missense |
c.1230C>T; p.C410C; 13:73075742-73075742 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.842_843insAT; p.M281fs*43; 13:73062441-73062442 |
prostate | carcinoma | Insertion - Frameshift |
c.341G>A; p.R114Q; 13:73061940-73061940 |
upper_aerodigestive_tract; pharynx | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.816G>A; p.Q272Q; 13:73062415-73062415 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.1165C>A; p.H389N; 13:73063853-73063853 |
large_intestine; colon | carcinoma | Substitution - Missense |
c.1165C>A; p.H389N; 13:73063853-73063853 |
pancreas | carcinoma | Substitution - Missense |
c.1165C>A; p.H389N; 13:73063853-73063853 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1165C>A; p.H389N; 13:73063853-73063853 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1165C>A; p.H389N; 13:73063853-73063853 |
pancreas | NS | Substitution - Missense |
c.811C>T; p.P271S; 13:73062410-73062410 |
skin | malignant_melanoma | Substitution - Missense |
c.447C>T; p.G149G; 13:73062046-73062046 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.864G>A; p.M288I; 13:73062463-73062463 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.1190A>C; p.H397P; 13:73063878-73063878 |
salivary_gland | carcinoma; adenoid_cystic_carcinoma | Substitution - Missense |
c.375T>G; p.T125T; 13:73061974-73061974 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.843G>T; p.M281I; 13:73062442-73062442 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.353C>T; p.S118L; 13:73061952-73061952 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.1317C>T; p.N439N; 13:73075829-73075829 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.725C>A; p.S242Y; 13:73062324-73062324 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.293C>G; p.P98R; 13:73061892-73061892 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.486_487insAC; p.E164fs*41; 13:73062085-73062086 |
biliary_tract; gallbladder | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.421C>T; p.P141S; 13:73062020-73062020 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.910C>A; p.P304T; 13:73062509-73062509 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |