Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7070

Name

THY1

Synonymous

Thy-1 cell surface antigen;THY1;Thy-1 cell surface antigen

Definition

CDw90|Thy-1 T-cell antigen|thy-1 antigen|thy-1 membrane glycoprotein

Position

11q23.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.07.

The copy number variations for various cancers

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There is no record for THY1

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.258G>T; p.M86I; 11:119420166-119420166

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.309G>A; p.T103T; 11:119420115-119420115

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - coding silent

c.340C>G; p.P114A; 11:119420084-119420084

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.116G>A; p.R39H; 11:119420308-119420308

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.116G>A; p.R39H; 11:119420308-119420308

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.403C>T; p.L135L; 11:119419491-119419491

 pancreascarcinomaSubstitution - coding silent

c.1A>G; p.M1V; 11:119420905-119420905

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.140C>A; p.P47H; 11:119420284-119420284

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.209C>A; p.P70H; 11:119420215-119420215

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.447C>T; p.S149S; 11:119419447-119419447

 skinmalignant_melanomaSubstitution - coding silent

c.81C>A; p.A27A; 11:119420343-119420343

 livercarcinomaSubstitution - coding silent

c.81C>A; p.A27A; 11:119420343-119420343

 livercarcinomaSubstitution - coding silent

c.469G>A; p.D157N; 11:119419425-119419425

 skinmalignant_melanomaSubstitution - Missense

c.78G>A; p.T26T; 11:119420346-119420346

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.183C>T; p.H61H; 11:119420241-119420241

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.104G>A; p.R35H; 11:119420320-119420320

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.104G>A; p.R35H; 11:119420320-119420320

 pancreascarcinomaSubstitution - Missense

c.162G>C; p.L54L; 11:119420262-119420262

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.130delA; p.S44fs*11; 11:119420294-119420294

 autonomic_ganglianeuroblastomaDeletion - Frameshift

c.165C>A; p.T55T; 11:119420259-119420259

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.166C>T; p.R56C; 11:119420258-119420258

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.53G>T; p.R18L; 11:119420371-119420371

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.177G>C; p.K59N; 11:119420247-119420247

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.342C>A; p.P114P; 11:119420082-119420082

 pancreascarcinomaSubstitution - coding silent

c.29T>A; p.L10Q; 11:119420877-119420877

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.128C>T; p.T43I; 11:119420296-119420296

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.453C>T; p.S151S; 11:119419441-119419441

 skinmalignant_melanomaSubstitution - coding silent

c.371G>A; p.R124K; 11:119420053-119420053

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.144C>A; p.I48I; 11:119420280-119420280

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.204G>A; p.G68G; 11:119420220-119420220

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.330C>T; p.G110G; 11:119420094-119420094

 lungcarcinoma; small_cell_carcinomaSubstitution - coding silent

c.277G>T; p.A93S; 11:119420147-119420147

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.422C>T; p.S141L; 11:119419472-119419472

 skinmalignant_melanomaSubstitution - Missense

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