Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7431

Name

VIM

Synonymous

vimentin;VIM;vimentin

Definition

epididymis luminal protein 113

Position

10p13

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.16.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1326T>G; p.L442L; 10:17236346-17236346

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.848A>G; p.N283S; 10:17233897-17233897

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.769G>A; p.D257N; 10:17233818-17233818

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.921C>T; p.D307D; 10:17234731-17234731

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.712C>T; p.H238Y; 10:17233674-17233674

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.628G>A; p.V210I; 10:17233590-17233590

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.307G>A; p.E103K; 10:17229729-17229729

 skin; scalpcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1092C>T; p.R364R; 10:17235252-17235252

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.946T>C; p.S316P; 10:17234756-17234756

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1047G>T; p.E349D; 10:17235207-17235207

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.661G>A; p.E221K; 10:17233623-17233623

 breastcarcinomaSubstitution - Missense

c.1342G>A; p.E448K; 10:17236362-17236362

 upper_aerodigestive_tract; pharynxcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.149G>A; p.R50H; 10:17229571-17229571

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.570G>A; p.Q190Q; 10:17230656-17230656

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.994G>T; p.A332S; 10:17234804-17234804

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.738G>T; p.Q246H; 10:17233787-17233787

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.552C>T; p.R184R; 10:17229974-17229974

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.212G>A; p.R71Q; 10:17229634-17229634

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.30C>T; p.S10S; 10:17229452-17229452

 skinmalignant_melanomaSubstitution - coding silent

c.30C>T; p.S10S; 10:17229452-17229452

 skinmalignant_melanomaSubstitution - coding silent

c.730G>A; p.E244K; 10:17233779-17233779

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.846_847GA>TT; p.K282>?; 10:17233895-17233896

 lungcarcinoma; adenocarcinomaComplex

c.715G>A; p.E239K; 10:17233677-17233677

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.715G>A; p.E239K; 10:17233677-17233677

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.715G>A; p.E239K; 10:17233677-17233677

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.884T>C; p.F295S; 10:17234694-17234694

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1262T>C; p.L421P; 10:17235878-17235878

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.923C>G; p.A308G; 10:17234733-17234733

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1131T>C; p.A377A; 10:17235291-17235291

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.105C>G; p.T35T; 10:17229527-17229527

 ovaryother; neoplasmSubstitution - coding silent

c.176G>T; p.G59V; 10:17229598-17229598

 adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; functioningSubstitution - Missense

c.81C>G; p.S27R; 10:17229503-17229503

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.11G>A; p.R4K; 10:17229433-17229433

 NSmalignant_melanomaSubstitution - Missense

c.928C>T; p.R310C; 10:17234738-17234738

 stomachadenocarcinomaSubstitution - Missense

c.1273G>A; p.E425K; 10:17235889-17235889

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1337C>G; p.T446R; 10:17236357-17236357

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.768C>T; p.I256I; 10:17233817-17233817

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1062A>T; p.E354D; 10:17235222-17235222

 livercarcinomaSubstitution - Missense

c.383A>C; p.N128T; 10:17229805-17229805

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.45C>A; p.F15L; 10:17229467-17229467

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.442G>C; p.D148H; 10:17229864-17229864

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.1078G>C; p.D360H; 10:17235238-17235238

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1376C>G; p.S459C; 10:17237246-17237246

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1348A>G; p.R450G; 10:17236368-17236368

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.453_454GG>AA; p.E151>?; 10:17229875-17229876

 NSmalignant_melanomaComplex

c.1034G>A; p.R345H; 10:17235194-17235194

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1220A>G; p.E407G; 10:17235380-17235380

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.797C>T; p.T266M; 10:17233846-17233846

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1349G>C; p.R450T; 10:17236369-17236369

 breastcarcinomaSubstitution - Missense

c.809G>A; p.R270H; 10:17233858-17233858

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.560A>G; p.E187G; 10:17229982-17229982

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.526G>A; p.D176N; 10:17229948-17229948

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.526G>A; p.D176N; 10:17229948-17229948

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1274-1G>T; p.?; 10:17236293-17236293

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.940C>T; p.Q314*; 10:17234750-17234750

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1314delA; p.R440fs*4; 10:17236334-17236334

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.569A>T; p.Q190L; 10:17230655-17230655

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.985G>T; p.E329*; 10:17234795-17234795

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.976C>T; p.L326F; 10:17234786-17234786

 skinmalignant_melanomaSubstitution - Missense

c.956A>G; p.Y319C; 10:17234766-17234766

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1138C>T; p.L380F; 10:17235298-17235298

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1221G>T; p.E407D; 10:17235381-17235381

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.741T>A; p.A247A; 10:17233790-17233790

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.673G>T; p.E225*; 10:17233635-17233635

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.170C>G; p.P57R; 10:17229592-17229592

 skinmalignant_melanomaSubstitution - Missense

c.721-9delT; p.?; 10:17233761-17233761

 stomachadenocarcinomaUnknown

c.888T>G; p.A296A; 10:17234698-17234698

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.1033C>T; p.R345C; 10:17235193-17235193

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1033C>T; p.R345C; 10:17235193-17235193

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.540G>A; p.E180E; 10:17229962-17229962

 skinmalignant_melanomaSubstitution - coding silent

c.319C>T; p.L107L; 10:17229741-17229741

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.163T>G; p.S55A; 10:17229585-17229585

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1297C>A; p.L433M; 10:17236317-17236317

 pancreasNSSubstitution - Missense

c.1017C>A; p.S339S; 10:17235177-17235177

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1186G>C; p.E396Q; 10:17235346-17235346

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1141C>G; p.R381G; 10:17235301-17235301

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1141C>G; p.R381G; 10:17235301-17235301

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.478C>A; p.Q160K; 10:17229900-17229900

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1295C>T; p.P432L; 10:17236315-17236315

 skinmalignant_melanomaSubstitution - Missense

c.583_584insAG; p.E198fs*38; 10:17230669-17230670

 endometriumcarcinoma; endometrioid_carcinomaInsertion - Frameshift

c.63G>A; p.A21A; 10:17229485-17229485

 skinmalignant_melanomaSubstitution - coding silent

c.1018C>A; p.L340M; 10:17235178-17235178

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1284G>T; p.L428L; 10:17236304-17236304

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1283T>C; p.L428P; 10:17236303-17236303

 livercarcinomaSubstitution - Missense

c.357C>A; p.D119E; 10:17229779-17229779

 thyroidother; neoplasmSubstitution - Missense

c.559G>A; p.E187K; 10:17229981-17229981

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.970C>T; p.Q324*; 10:17234780-17234780

 breastcarcinomaSubstitution - Nonsense

c.856G>T; p.E286*; 10:17233905-17233905

 livercarcinomaSubstitution - Nonsense

c.856G>T; p.E286*; 10:17233905-17233905

 livercarcinomaSubstitution - Nonsense

c.1060G>A; p.E354K; 10:17235220-17235220

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1301T>C; p.V434A; 10:17236321-17236321

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.100T>C; p.S34P; 10:17229522-17229522

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.974C>T; p.S325F; 10:17234784-17234784

 skinmalignant_melanomaSubstitution - Missense

c.459G>A; p.E153E; 10:17229881-17229881

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.812A>T; p.D271V; 10:17233861-17233861

 soft_tissue; striated_musclerhabdomyosarcomaSubstitution - Missense

c.812A>T; p.D271V; 10:17233861-17233861

 soft_tissue; striated_musclerhabdomyosarcoma; alveolarSubstitution - Missense

c.1075C>A; p.Q359K; 10:17235235-17235235

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.152G>A; p.S51N; 10:17229574-17229574

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.695C>T; p.A232V; 10:17233657-17233657

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.695C>T; p.A232V; 10:17233657-17233657

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1219G>A; p.E407K; 10:17235379-17235379

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.775G>A; p.D259N; 10:17233824-17233824

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.721G>A; p.E241K; 10:17233770-17233770

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.981C>A; p.T327T; 10:17234791-17234791

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.819T>A; p.R273R; 10:17233868-17233868

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.649C>T; p.R217C; 10:17233611-17233611

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.694G>T; p.A232S; 10:17233656-17233656

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.466G>A; p.E156K; 10:17229888-17229888

 skinmalignant_melanomaSubstitution - Missense

c.905C>T; p.A302V; 10:17234715-17234715

 livercarcinomaSubstitution - Missense

c.905C>T; p.A302V; 10:17234715-17234715

 livercarcinomaSubstitution - Missense

c.700T>G; p.L234V; 10:17233662-17233662

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.736C>A; p.Q246K; 10:17233785-17233785

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.643C>G; p.L215V; 10:17233605-17233605

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.559G>T; p.E187*; 10:17229981-17229981

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.482T>G; p.V161G; 10:17229904-17229904

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.514G>A; p.E172K; 10:17229936-17229936

 skinmalignant_melanomaSubstitution - Missense

c.194_195CC>TT; p.S65F; 10:17229616-17229617

 skinmalignant_melanomaSubstitution - Missense

c.1035T>C; p.R345R; 10:17235195-17235195

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1024C>A; p.R342S; 10:17235184-17235184

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.191G>A; p.R64H; 10:17229613-17229613

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1285G>T; p.D429Y; 10:17236305-17236305

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.996C>T; p.A332A; 10:17234806-17234806

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.996C>T; p.A332A; 10:17234806-17234806

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.959G>A; p.R320Q; 10:17234769-17234769

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1054G>A; p.A352T; 10:17235214-17235214

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.556C>T; p.R186W; 10:17229978-17229978

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1327C>T; p.L443L; 10:17236347-17236347

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1313C>G; p.S438*; 10:17236333-17236333

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

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