| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 81848 |
Name | SPRY4 |
Synonymous | sprouty homolog 4 (Drosophila);SPRY4;sprouty homolog 4 (Drosophila) |
Definition | protein sprouty homolog 4 |
Position | 5q31.3 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.07. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.444A>T; p.S148S; 5:142314734-142314734 |
breast | carcinoma | Substitution - coding silent |
c.903G>A; p.T301T; 5:142314275-142314275 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.903G>A; p.T301T; 5:142314275-142314275 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.868C>T; p.R290C; 5:142314310-142314310 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | Substitution - Missense |
c.338T>A; p.I113N; 5:142314840-142314840 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia | Substitution - Missense |
c.765C>T; p.C255C; 5:142314413-142314413 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.510G>A; p.A170A; 5:142314668-142314668 |
prostate | carcinoma; adenocarcinoma | Substitution - coding silent |
c.45C>T; p.S15S; 5:142315133-142315133 |
skin | malignant_melanoma | Substitution - coding silent |
c.45C>T; p.S15S; 5:142315133-142315133 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm | Substitution - coding silent |
c.352C>T; p.R118C; 5:142314826-142314826 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.923C>G; p.A308G; 5:142314255-142314255 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.811C>T; p.L271L; 5:142314367-142314367 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.643A>G; p.T215A; 5:142314535-142314535 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.276C>T; p.G92G; 5:142314902-142314902 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.900C>T; p.H300H; 5:142314278-142314278 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.79C>T; p.P27S; 5:142315099-142315099 |
skin | malignant_melanoma | Substitution - Missense |
c.683G>A; p.G228D; 5:142314495-142314495 |
lung; right_lower_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.158G>T; p.R53L; 5:142315020-142315020 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.158G>T; p.R53L; 5:142315020-142315020 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.662C>T; p.T221M; 5:142314516-142314516 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.327C>T; p.T109T; 5:142314851-142314851 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.426C>T; p.P142P; 5:142314752-142314752 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.203C>T; p.T68I; 5:142314975-142314975 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.367A>G; p.S123G; 5:142314811-142314811 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.632G>T; p.C211F; 5:142314546-142314546 |
lung | carcinoma; large_cell_carcinoma | Substitution - Missense |
c.632G>T; p.C211F; 5:142314546-142314546 |
lung | carcinoma; large_cell_carcinoma | Substitution - Missense |
c.299C>T; p.T100M; 5:142314879-142314879 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.153C>G; p.H51Q; 5:142315025-142315025 |
ovary | other; neoplasm | Substitution - Missense |
c.769C>T; p.R257C; 5:142314409-142314409 |
breast | carcinoma | Substitution - Missense |
c.427G>T; p.V143L; 5:142314751-142314751 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.681G>T; p.Q227H; 5:142314497-142314497 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.610G>A; p.V204I; 5:142314568-142314568 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.519C>T; p.P173P; 5:142314659-142314659 |
breast | carcinoma | Substitution - coding silent |
c.157C>T; p.R53W; 5:142315021-142315021 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.157C>T; p.R53W; 5:142315021-142315021 |
genital_tract; extragonadal | germ_cell_tumour; yolk_sac_tumour | Substitution - Missense |
c.796G>A; p.V266M; 5:142314382-142314382 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.513C>T; p.V171V; 5:142314665-142314665 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - coding silent |
c.513C>T; p.V171V; 5:142314665-142314665 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - coding silent |
c.883G>A; p.G295S; 5:142314295-142314295 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.349G>A; p.G117R; 5:142314829-142314829 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia | Substitution - Missense |
c.349G>A; p.G117R; 5:142314829-142314829 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia | Substitution - Missense |
c.855G>T; p.Q285H; 5:142314323-142314323 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.446C>G; p.P149R; 5:142314732-142314732 |
genital_tract; extragonadal | germ_cell_tumour; seminoma | Substitution - Missense |
c.647T>C; p.L216P; 5:142314531-142314531 |
liver | carcinoma | Substitution - Missense |
c.647T>C; p.L216P; 5:142314531-142314531 |
liver | carcinoma | Substitution - Missense |
c.647T>C; p.L216P; 5:142314531-142314531 |
liver | carcinoma | Substitution - Missense |
c.647T>C; p.L216P; 5:142314531-142314531 |
liver | carcinoma | Substitution - Missense |
c.212T>C; p.V71A; 5:142314966-142314966 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.738C>A; p.P246P; 5:142314440-142314440 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.467C>T; p.P156L; 5:142314711-142314711 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.467C>T; p.P156L; 5:142314711-142314711 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.128C>G; p.P43R; 5:142315050-142315050 |
liver | carcinoma | Substitution - Missense |
c.304G>A; p.A102T; 5:142314874-142314874 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.142C>T; p.R48W; 5:142315036-142315036 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia | Substitution - Missense |
c.400C>T; p.L134F; 5:142314778-142314778 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.380_382delGCA; p.S127delS; 5:142314796-142314798 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - In frame |
c.380_382delGCA; p.S127delS; 5:142314796-142314798 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - In frame |
c.348C>T; p.S116S; 5:142314830-142314830 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.348C>T; p.S116S; 5:142314830-142314830 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.949A>G; p.R317G; 5:142314229-142314229 |
pancreas | carcinoma | Substitution - Missense |
c.505C>T; p.P169S; 5:142314673-142314673 |
skin | malignant_melanoma | Substitution - Missense |
c.158G>A; p.R53Q; 5:142315020-142315020 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.795C>T; p.S265S; 5:142314383-142314383 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.795C>T; p.S265S; 5:142314383-142314383 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.546C>T; p.C182C; 5:142314632-142314632 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.328C>T; p.H110Y; 5:142314850-142314850 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.538T>G; p.L180V; 5:142314640-142314640 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.726C>T; p.C242C; 5:142314452-142314452 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.159G>A; p.R53R; 5:142315019-142315019 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.44C>T; p.S15F; 5:142315134-142315134 |
skin | malignant_melanoma | Substitution - Missense |
c.589delC; p.R197fs*85; 5:142314589-142314589 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.589delC; p.R197fs*85; 5:142314589-142314589 |
large_intestine; caecum | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.589delC; p.R197fs*85; 5:142314589-142314589 |
pancreas | carcinoma; ductal_carcinoma | Deletion - Frameshift |