| General information | Literature | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 81848 |
Name | SPRY4 |
Synonymous | HH17;sprouty homolog 4 (Drosophila);SPRY4;sprouty homolog 4 (Drosophila) |
Definition | protein sprouty homolog 4 |
Position | 5q31.3 |
Gene type | protein-coding |
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Title |
Abstract |
| SPRY4-mediated ERK1/2 signaling inhibition abolishes 17beta-estradiol-induced cell growth in endometrial adenocarcinoma cell. | OBJECTIVE: Basic fibroblast growth factor (FGF2)-mediated Extracellular signal-regulated kinases1/2 (ERK1/2) signaling is a critical modulator in angiogenesis. SPRY4 has been reported to be a feedback negative regulator of FGFs-induced ERK1/2 signaling. The aim of this study was to explore the role of SPRY4 in endometrial adenocarcinoma cell. MATERIALS AND METHODS: The effect of SPRY4 expression on FGF2-mediated ERK1/2 signaling was detected by luciferase assay and Western blot analysis. The growth of Ishikawa cells was detected using colony formation assay and cell number counting experiment. RESULTS: We found that plasmid-driven SPRY4 expression efficiently blocked the activity of FGF2-induced ERK1/2 signaling in Ishikawa cells. SPRY4 expression significantly reduced the proliferation and 17beta-estradiol-induced proliferation of Ishikawa cells. CONCLUSION: SPRY4 may function as a tumor suppressor in endometrial adenocarcinoma. |