Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

84872

Name

ZC3H10

Synonymous

zinc finger CCCH-type containing 10;ZC3H10;zinc finger CCCH-type containing 10

Definition

zinc finger CCCH domain-containing protein 10|zinc finger CCCH-type domain containing 10

Position

12q13.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.11.

The copy number variations for various cancers

Top

There is no record for ZC3H10

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.781C>T; p.L261L; 12:56121343-56121343

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.469C>T; p.R157C; 12:56121031-56121031

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.469C>T; p.R157C; 12:56121031-56121031

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.995T>G; p.V332G; 12:56121557-56121557

 pancreascarcinomaSubstitution - Missense

c.995T>G; p.V332G; 12:56121557-56121557

 pancreascarcinoid-endocrine_tumourSubstitution - Missense

c.946C>G; p.L316V; 12:56121508-56121508

 livercarcinomaSubstitution - Missense

c.943A>G; p.T315A; 12:56121505-56121505

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.163C>T; p.R55C; 12:56120725-56120725

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1283G>T; p.R428L; 12:56121845-56121845

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.215G>A; p.S72N; 12:56120777-56120777

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1189G>T; p.V397L; 12:56121751-56121751

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.7G>C; p.D3H; 12:56120569-56120569

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.642C>T; p.C214C; 12:56121204-56121204

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.27C>T; p.N9N; 12:56120589-56120589

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.141G>A; p.R47R; 12:56120703-56120703

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.137T>C; p.L46S; 12:56120699-56120699

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.629G>A; p.R210Q; 12:56121191-56121191

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.629G>A; p.R210Q; 12:56121191-56121191

 prostatecarcinomaSubstitution - Missense

c.697C>T; p.R233*; 12:56121259-56121259

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.697C>T; p.R233*; 12:56121259-56121259

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1258T>C; p.Y420H; 12:56121820-56121820

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.562G>A; p.D188N; 12:56121124-56121124

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.645delC; p.P217fs*24; 12:56121207-56121207

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.645delC; p.P217fs*24; 12:56121207-56121207

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.645delC; p.P217fs*24; 12:56121207-56121207

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1291G>A; p.A431T; 12:56121853-56121853

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.683G>A; p.S228N; 12:56121245-56121245

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.1062A>C; p.P354P; 12:56121624-56121624

 ovaryother; neoplasmSubstitution - coding silent

c.1062A>C; p.P354P; 12:56121624-56121624

 pancreascarcinoid-endocrine_tumourSubstitution - coding silent

c.1062A>C; p.P354P; 12:56121624-56121624

 ovaryother; neoplasmSubstitution - coding silent

c.935_936delCT; p.T314fs*30; 12:56121497-56121498

 skinmalignant_melanomaDeletion - Frameshift

c.170G>A; p.R57Q; 12:56120732-56120732

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1200G>A; p.S400S; 12:56121762-56121762

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.542T>C; p.V181A; 12:56121104-56121104

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1116A>C; p.T372T; 12:56121678-56121678

 skinmalignant_melanomaSubstitution - coding silent

c.870G>A; p.A290A; 12:56121432-56121432

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1266C>T; p.I422I; 12:56121828-56121828

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1266C>T; p.I422I; 12:56121828-56121828

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1266C>T; p.I422I; 12:56121828-56121828

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.886G>A; p.A296T; 12:56121448-56121448

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.303T>C; p.D101D; 12:56120865-56120865

 skinmalignant_melanomaSubstitution - coding silent

c.192C>T; p.S64S; 12:56120754-56120754

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.628C>T; p.R210W; 12:56121190-56121190

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.145G>C; p.V49L; 12:56120707-56120707

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.1087A>T; p.T363S; 12:56121649-56121649

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1233C>T; p.S411S; 12:56121795-56121795

 pancreascarcinomaSubstitution - coding silent

c.890C>T; p.P297L; 12:56121452-56121452

 skinmalignant_melanomaSubstitution - Missense

c.181C>T; p.P61S; 12:56120743-56120743

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.867A>G; p.P289P; 12:56121429-56121429

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1282C>T; p.R428C; 12:56121844-56121844

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1282C>T; p.R428C; 12:56121844-56121844

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1282C>T; p.R428C; 12:56121844-56121844

 large_intestine; coloncarcinomaSubstitution - Missense

c.1282C>T; p.R428C; 12:56121844-56121844

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.985C>A; p.Q329K; 12:56121547-56121547

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1283G>A; p.R428H; 12:56121845-56121845

 pancreascarcinomaSubstitution - Missense

c.1111C>G; p.Q371E; 12:56121673-56121673

 breastcarcinomaSubstitution - Missense

c.1027_1039del13; p.T343fs*12; 12:56121589-56121601

 stomachcarcinoma; diffuse_adenocarcinomaDeletion - Frameshift

c.749G>T; p.R250L; 12:56121311-56121311

 breastcarcinomaSubstitution - Missense

c.752T>G; p.V251G; 12:56121314-56121314

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.100G>T; p.G34C; 12:56120662-56120662

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1256C>T; p.T419I; 12:56121818-56121818

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.670T>C; p.S224P; 12:56121232-56121232

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.827G>A; p.R276H; 12:56121389-56121389

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.827G>A; p.R276H; 12:56121389-56121389

 skinmalignant_melanomaSubstitution - Missense

c.569_571delATG; p.D191delD; 12:56121131-56121133

 oesophaguscarcinoma; adenocarcinomaDeletion - In frame

c.107C>G; p.A36G; 12:56120669-56120669

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.107C>G; p.A36G; 12:56120669-56120669

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.107C>G; p.A36G; 12:56120669-56120669

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.107C>G; p.A36G; 12:56120669-56120669

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.677A>C; p.E226A; 12:56121239-56121239

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.359C>T; p.A120V; 12:56120921-56120921

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.942T>C; p.T314T; 12:56121504-56121504

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.898G>C; p.G300R; 12:56121460-56121460

 livercarcinomaSubstitution - Missense

c.898G>C; p.G300R; 12:56121460-56121460

 livercarcinomaSubstitution - Missense

c.748C>T; p.R250W; 12:56121310-56121310

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.748C>T; p.R250W; 12:56121310-56121310

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1224C>T; p.I408I; 12:56121786-56121786

 skinmalignant_melanomaSubstitution - coding silent

c.576C>A; p.I192I; 12:56121138-56121138

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.103G>A; p.G35R; 12:56120665-56120665

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.650delC; p.P217fs*24; 12:56121212-56121212

 prostatecarcinomaDeletion - Frameshift

c.402G>T; p.K134N; 12:56120964-56120964

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.402G>T; p.K134N; 12:56120964-56120964

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.601G>A; p.E201K; 12:56121163-56121163

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.601G>A; p.E201K; 12:56121163-56121163

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

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