| General information | Literature | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 84872 |
Name | ZC3H10 |
Synonymous | ZC3HDC10;zinc finger CCCH-type containing 10;ZC3H10;zinc finger CCCH-type containing 10 |
Definition | zinc finger CCCH domain-containing protein 10|zinc finger CCCH-type domain containing 10 |
Position | 12q13.2 |
Gene type | protein-coding |
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Title |
Abstract |
| Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration. | Tumor necrosis factor alpha (TNFalpha) is a pleiotropic cytokine involved in apoptotic cell death, cellular proliferation, differentiation, inflammation, and tumorigenesis. In tumors it is secreted by tumor associated macrophages and can have both pro- and anti-tumorigenic effects. To identify genes regulated by TNFalpha, we performed a gene trap screen in the mammary carcinoma cell line MCF-7 and recovered 64 unique, TNFalpha-induced gene trap integration sites. Among these were the genes coding for the zinc finger protein ZC3H10 and for the transcription factor grainyhead-like 3 (GRHL3). In line with the dual effects of TNFalpha on tumorigenesis, we found that ZC3H10 inhibits anchorage independent growth in soft agar suggesting a tumor suppressor function, whereas GRHL3 strongly stimulated the migration of endothelial cells which is consistent with an angiogenic, pro-tumorigenic function. |