Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

8795

Name

TNFRSF10B

Synonymous

tumor necrosis factor receptor superfamily, member 10b;TNFRSF10B;tumor necrosis factor receptor superfamily, member 10b

Definition

Fas-like protein|TNF receptor superfamily member 10b|TNF-related apoptosis-inducing ligand receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|d

Position

8p22-p21

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.20.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.470G>A; p.R157H; 8:23029616-23029616

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.544G>T; p.E182*; 8:23028535-23028535

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.544G>T; p.E182*; 8:23028535-23028535

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.803A>G; p.E268G; 8:23027266-23027266

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.231A>G; p.S77S; 8:23043157-23043157

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.766G>A; p.E256K; 8:23027736-23027736

 livercarcinomaSubstitution - Missense

c.1181G>T; p.G394V; 8:23022813-23022813

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.939A>T; p.E313D; 8:23024258-23024258

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.766G>A; p.E256K; 8:23027736-23027736

 livercarcinomaSubstitution - Missense

c.1180G>A; p.G394R; 8:23022814-23022814

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.640A>G; p.I214V; 8:23028439-23028439

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.1027G>T; p.D343Y; 8:23022967-23022967

 pancreascarcinomaSubstitution - Missense

c.271G>A; p.G91S; 8:23030852-23030852

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.529G>A; p.E177K; 8:23028550-23028550

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.23C>A; p.A8D; 8:23068872-23068872

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.982C>T; p.P328S; 8:23024215-23024215

 skinmalignant_melanomaSubstitution - Missense

c.476+1G>T; p.?; 8:23029609-23029609

 lungcarcinoma; squamous_cell_carcinomaUnknown

c.825C>G; p.I275M; 8:23027244-23027244

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.923C>T; p.S308L; 8:23027146-23027146

 stomachadenocarcinomaSubstitution - Missense

c.205C>T; p.P69S; 8:23043183-23043183

 skin; neckmalignant_melanomaSubstitution - Missense

c.174A>T; p.Q58H; 8:23043214-23043214

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.921G>C; p.E307D; 8:23027148-23027148

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.281G>A; p.C94Y; 8:23030842-23030842

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.919G>A; p.E307K; 8:23027150-23027150

 skinmalignant_melanomaSubstitution - Missense

c.38G>A; p.G13E; 8:23068857-23068857

 skinmalignant_melanomaSubstitution - Missense

c.461G>A; p.R154Q; 8:23029625-23029625

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.290G>A; p.C97Y; 8:23030833-23030833

 NSNSSubstitution - Missense

c.791G>A; p.R264Q; 8:23027278-23027278

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.914C>T; p.P305L; 8:23027155-23027155

 skinmalignant_melanomaSubstitution - Missense

c.914C>T; p.P305L; 8:23027155-23027155

 skinmalignant_melanomaSubstitution - Missense

c.22G>T; p.A8S; 8:23068873-23068873

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.649G>T; p.G217*; 8:23028430-23028430

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1314C>A; p.A438A; 8:23022680-23022680

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.528C>T; p.I176I; 8:23028551-23028551

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.144+2T>C; p.?; 8:23068749-23068749

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.985G>T; p.A329S; 8:23024212-23024212

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1030G>T; p.D344Y; 8:23022964-23022964

 breastcarcinomaSubstitution - Missense

c.1113T>C; p.A371A; 8:23022881-23022881

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1269G>C; p.L423F; 8:23022725-23022725

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.250+2T>C; p.?; 8:23043136-23043136

 stomachcarcinoma; adenocarcinomaUnknown

c.20A>G; p.N7S; 8:23068875-23068875

 pancreascarcinomaSubstitution - Missense

c.1164G>C; p.K388N; 8:23022830-23022830

 pancreascarcinomaSubstitution - Missense

c.298G>T; p.G100*; 8:23030825-23030825

 livercarcinomaSubstitution - Nonsense

c.344G>A; p.R115H; 8:23030779-23030779

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.591G>A; p.T197T; 8:23028488-23028488

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.226C>T; p.P76S; 8:23043162-23043162

 skin; extremitymalignant_melanomaSubstitution - Missense

c.746C>T; p.S249L; 8:23028333-23028333

 skinmalignant_melanomaSubstitution - Missense

c.382C>T; p.P128S; 8:23029704-23029704

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.418G>A; p.E140K; 8:23029668-23029668

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.463A>G; p.K155E; 8:23029623-23029623

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.820G>T; p.E274*; 8:23027249-23027249

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1181G>A; p.G394E; 8:23022813-23022813

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1010-1G>C; p.?; 8:23022985-23022985

 livercarcinoma; hepatocellular_carcinomaUnknown

c.25C>A; p.P9T; 8:23068870-23068870

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1252A>C; p.I418L; 8:23022742-23022742

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.825C>T; p.I275I; 8:23027244-23027244

 skinmalignant_melanomaSubstitution - coding silent

c.248C>T; p.P83L; 8:23043140-23043140

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1047G>T; p.V349V; 8:23022947-23022947

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1131C>A; p.G377G; 8:23022863-23022863

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.763C>A; p.P255T; 8:23027739-23027739

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

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