Entrez Gene

Basic Information
Gene ID	9353
Name	SLIT2
Synonymous	slit homolog 2 (Drosophila);SLIT2;slit homolog 2 (Drosophila)
Definition	slit homolog 2 protein
Position	4p15.2
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.11.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.586A>T; p.N196Y; 4:20486246-20486246	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3292delT; p.Y1098fs*43; 4:20595806-20595806	lung	carcinoma; small_cell_carcinoma	Deletion - Frameshift
c.1367G>A; p.R456H; 4:20524106-20524106	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.3220G>C; p.D1074H; 4:20595734-20595734	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.680G>A; p.R227K; 4:20488887-20488887	central_nervous_system; brain	glioma	Substitution - Missense
c.2026G>A; p.G676R; 4:20541502-20541502	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.931A>G; p.T311A; 4:20510511-20510511	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.796C>T; p.P266S; 4:20491781-20491781	skin	malignant_melanoma	Substitution - Missense
c.3135_3136CC>TT; p.P1046S; 4:20589690-20589691	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.967T>C; p.Y323H; 4:20510547-20510547	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.891T>C; p.N297N; 4:20491876-20491876	skin	malignant_melanoma	Substitution - coding silent
c.1557C>T; p.C519C; 4:20529043-20529043	prostate	adenoma	Substitution - coding silent
c.1249T>G; p.S417A; 4:20523878-20523878	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3728T>C; p.V1243A; 4:20610048-20610048	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3089-7G>A; p.?; 4:20589637-20589637	liver	carcinoma	Unknown
c.1964C>A; p.S655Y; 4:20539572-20539572	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.4114A>T; p.N1372Y; 4:20617176-20617176	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1042C>T; p.R348C; 4:20511121-20511121	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1042C>T; p.R348C; 4:20511121-20511121	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1472A>G; p.D491G; 4:20528958-20528958	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1042C>T; p.R348C; 4:20511121-20511121	ovary	other; neoplasm	Substitution - Missense
c.1042C>T; p.R348C; 4:20511121-20511121	ovary	other; neoplasm	Substitution - Missense
c.3640C>T; p.R1214C; 4:20598343-20598343	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2909G>A; p.G970E; 4:20567576-20567576	skin	malignant_melanoma	Substitution - Missense
c.1018G>A; p.A340T; 4:20511097-20511097	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3234C>T; p.D1078D; 4:20595748-20595748	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2501G>T; p.G834V; 4:20550838-20550838	pancreas	carcinoma	Substitution - Missense
c.3750G>A; p.Q1250Q; 4:20610070-20610070	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.3234C>T; p.D1078D; 4:20595748-20595748	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.903C>A; p.T301T; 4:20491888-20491888	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.3234C>T; p.D1078D; 4:20595748-20595748	central_nervous_system; brain	glioma	Substitution - coding silent
c.2501G>T; p.G834V; 4:20550838-20550838	pancreas	carcinoma	Substitution - Missense
c.3750G>A; p.Q1250Q; 4:20610070-20610070	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.3234C>T; p.D1078D; 4:20595748-20595748	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3750G>A; p.Q1250Q; 4:20610070-20610070	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1430G>A; p.R477H; 4:20524169-20524169	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1239G>A; p.K413K; 4:20523868-20523868	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2501G>T; p.G834V; 4:20550838-20550838	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.2095G>T; p.E699*; 4:20541571-20541571	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2246C>T; p.P749L; 4:20542596-20542596	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2245_2246CC>AT; p.P749>?; 4:20542595-20542596	large_intestine; colon	carcinoma; adenocarcinoma	Complex
c.3750G>A; p.Q1250Q; 4:20610070-20610070	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.4348+4A>C; p.?; 4:20617654-20617654	oesophagus	carcinoma; adenocarcinoma	Unknown
c.1234G>A; p.A412T; 4:20523863-20523863	NS	NS	Substitution - Missense
c.52G>T; p.A18S; 4:20253867-20253867	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2615A>G; p.D872G; 4:20553858-20553858	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2837C>T; p.P946L; 4:20567373-20567373	skin	malignant_melanoma	Substitution - Missense
c.2837C>T; p.P946L; 4:20567373-20567373	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.902C>A; p.T301N; 4:20491887-20491887	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2837C>T; p.P946L; 4:20567373-20567373	skin; mucosal	malignant_melanoma	Substitution - Missense
c.4087A>G; p.M1363V; 4:20617149-20617149	skin; mucosal	malignant_melanoma	Substitution - Missense
c.3827A>G; p.D1276G; 4:20610147-20610147	liver	carcinoma	Substitution - Missense
c.3662C>A; p.T1221N; 4:20598365-20598365	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.3152C>G; p.S1051*; 4:20589707-20589707	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.4365G>A; p.G1455G; 4:20618784-20618784	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1032C>T; p.F344F; 4:20511111-20511111	skin; arm	malignant_melanoma	Substitution - coding silent
c.1920T>C; p.N640N; 4:20539528-20539528	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1691A>C; p.N564T; 4:20533574-20533574	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3474A>T; p.K1158N; 4:20596568-20596568	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3176G>A; p.G1059E; 4:20589731-20589731	skin	malignant_melanoma	Substitution - Missense
c.3618C>T; p.I1206I; 4:20598321-20598321	skin; shoulder	malignant_melanoma	Substitution - coding silent
c.2446A>C; p.I816L; 4:20549085-20549085	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2106C>A; p.I702I; 4:20541582-20541582	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1674T>C; p.P558P; 4:20532044-20532044	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.4161C>T; p.P1387P; 4:20617463-20617463	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2143+2T>C; p.?; 4:20541621-20541621	lung	carcinoma; adenocarcinoma	Unknown
c.4161C>T; p.P1387P; 4:20617463-20617463	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.141C>A; p.R47R; 4:20253956-20253956	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1176T>C; p.F392F; 4:20523805-20523805	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.4110G>A; p.R1370R; 4:20617172-20617172	skin	malignant_melanoma	Substitution - coding silent
c.1675C>T; p.Q559*; 4:20532045-20532045	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2998G>A; p.D1000N; 4:20568914-20568914	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4126C>T; p.L1376F; 4:20617188-20617188	skin	malignant_melanoma	Substitution - Missense
c.4481C>G; p.P1494R; 4:20618900-20618900	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4363G>T; p.G1455W; 4:20618782-20618782	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2494C>G; p.L832V; 4:20550831-20550831	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.340C>A; p.H114N; 4:20268826-20268826	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.221_222insT; p.A76fs*4; 4:20256713-20256714	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2464G>A; p.D822N; 4:20549103-20549103	skin	malignant_melanoma	Substitution - Missense
c.2669G>A; p.G890E; 4:20553912-20553912	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3125A>T; p.Q1042L; 4:20589680-20589680	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1537G>A; p.E513K; 4:20529023-20529023	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1477C>T; p.R493*; 4:20528963-20528963	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.3349A>C; p.M1117L; 4:20596443-20596443	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4073G>T; p.C1358F; 4:20617135-20617135	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.4162A>G; p.I1388V; 4:20617464-20617464	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.824C>T; p.A275V; 4:20491809-20491809	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2103C>T; p.P701P; 4:20541579-20541579	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.3043G>A; p.D1015N; 4:20568959-20568959	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1292C>T; p.P431L; 4:20524031-20524031	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1644G>T; p.L548F; 4:20532014-20532014	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1258C>T; p.R420W; 4:20523887-20523887	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4215C>T; p.L1405L; 4:20617517-20617517	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1112T>C; p.L371P; 4:20519435-20519435	breast	carcinoma	Substitution - Missense
c.4260G>T; p.K1420N; 4:20617562-20617562	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1433delG; p.C478fs*19; 4:20524172-20524172	breast	carcinoma	Deletion - Frameshift
c.3127G>A; p.D1043N; 4:20589682-20589682	skin	malignant_melanoma	Substitution - Missense
c.3813C>T; p.S1271S; 4:20610133-20610133	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1488A>C; p.L496F; 4:20528974-20528974	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.3260A>C; p.N1087T; 4:20595774-20595774	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1796A>T; p.H599L; 4:20533679-20533679	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1904T>A; p.L635H; 4:20539512-20539512	skin	malignant_melanoma	Substitution - Missense
c.3831T>A; p.S1277S; 4:20610151-20610151	skin	malignant_melanoma	Substitution - coding silent
c.849C>T; p.I283I; 4:20491834-20491834	skin	malignant_melanoma	Substitution - coding silent
c.849C>T; p.I283I; 4:20491834-20491834	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.849C>T; p.I283I; 4:20491834-20491834	skin	malignant_melanoma	Substitution - coding silent
c.2539G>A; p.D847N; 4:20550876-20550876	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2539G>A; p.D847N; 4:20550876-20550876	skin; shoulder	malignant_melanoma	Substitution - Missense
c.2788G>A; p.D930N; 4:20567324-20567324	skin	malignant_melanoma	Substitution - Missense
c.2539G>A; p.D847N; 4:20550876-20550876	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.90G>A; p.A30A; 4:20253905-20253905	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.673C>T; p.R225C; 4:20488880-20488880	breast	carcinoma	Substitution - Missense
c.127G>C; p.G43R; 4:20253942-20253942	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4103A>T; p.D1368V; 4:20617165-20617165	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2438T>C; p.L813P; 4:20549077-20549077	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2824C>T; p.R942*; 4:20567360-20567360	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.467+2T>C; p.?; 4:20467825-20467825	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.782A>G; p.Q261R; 4:20491767-20491767	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1400G>T; p.R467I; 4:20524139-20524139	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3789C>T; p.I1263I; 4:20610109-20610109	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1507G>A; p.D503N; 4:20528993-20528993	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.713G>A; p.G238D; 4:20488920-20488920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4155C>T; p.C1385C; 4:20617457-20617457	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3789C>T; p.I1263I; 4:20610109-20610109	skin	malignant_melanoma	Substitution - coding silent
c.2932G>T; p.E978*; 4:20567599-20567599	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.4361G>A; p.R1454Q; 4:20618780-20618780	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2629G>A; p.E877K; 4:20553872-20553872	skin	malignant_melanoma	Substitution - Missense
c.1096A>G; p.S366G; 4:20519419-20519419	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1778G>C; p.R593P; 4:20533661-20533661	kidney	other; neoplasm	Substitution - Missense
c.4078G>A; p.E1360K; 4:20617140-20617140	skin	malignant_melanoma	Substitution - Missense
c.2211C>T; p.V737V; 4:20542561-20542561	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1983C>T; p.L661L; 4:20541459-20541459	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2500G>A; p.G834R; 4:20550837-20550837	skin	malignant_melanoma	Substitution - Missense
c.483C>A; p.N161K; 4:20480731-20480731	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4281G>T; p.R1427S; 4:20617583-20617583	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3306C>T; p.C1102C; 4:20595820-20595820	central_nervous_system; brain	glioma	Substitution - coding silent
c.3306C>T; p.C1102C; 4:20595820-20595820	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.30C>T; p.S10S; 4:20253845-20253845	skin	malignant_melanoma	Substitution - coding silent
c.1993C>T; p.P665S; 4:20541469-20541469	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1364C>T; p.A455V; 4:20524103-20524103	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1723G>A; p.E575K; 4:20533606-20533606	skin	malignant_melanoma	Substitution - Missense
c.3522T>G; p.P1174P; 4:20596616-20596616	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.305T>A; p.L102H; 4:20257921-20257921	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.3219C>T; p.C1073C; 4:20595733-20595733	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.3219C>T; p.C1073C; 4:20595733-20595733	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2363G>A; p.R788K; 4:20548505-20548505	skin	malignant_melanoma	Substitution - Missense
c.1723G>A; p.E575K; 4:20533606-20533606	skin	malignant_melanoma	Substitution - Missense
c.1850G>A; p.R617Q; 4:20539458-20539458	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3147C>T; p.H1049H; 4:20589702-20589702	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2949-10T>C; p.?; 4:20568855-20568855	liver	carcinoma	Unknown
c.1366C>T; p.R456C; 4:20524105-20524105	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3219C>T; p.C1073C; 4:20595733-20595733	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3147C>T; p.H1049H; 4:20589702-20589702	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.3147C>T; p.H1049H; 4:20589702-20589702	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1381C>T; p.R461C; 4:20524120-20524120	pancreas	carcinoma	Substitution - Missense
c.3520C>T; p.P1174S; 4:20596614-20596614	skin	malignant_melanoma	Substitution - Missense
c.3520C>T; p.P1174S; 4:20596614-20596614	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1499G>C; p.C500S; 4:20528985-20528985	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1115T>G; p.F372C; 4:20519438-20519438	breast	carcinoma	Substitution - Missense
c.1381C>T; p.R461C; 4:20524120-20524120	prostate	carcinoma	Substitution - Missense
c.276C>T; p.S92S; 4:20257892-20257892	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.3520C>T; p.P1174S; 4:20596614-20596614	skin	malignant_melanoma	Substitution - Missense
c.2490-2A>T; p.?; 4:20550825-20550825	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.2926G>A; p.E976K; 4:20567593-20567593	skin	malignant_melanoma	Substitution - Missense
c.3166A>G; p.T1056A; 4:20589721-20589721	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1607C>T; p.A536V; 4:20529093-20529093	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4074C>T; p.C1358C; 4:20617136-20617136	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.4482G>A; p.P1494P; 4:20618901-20618901	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2490-2A>T; p.?; 4:20550825-20550825	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.2490-2A>T; p.?; 4:20550825-20550825	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.3868G>A; p.V1290M; 4:20616930-20616930	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.965C>T; p.P322L; 4:20510545-20510545	skin	malignant_melanoma	Substitution - Missense
c.758G>A; p.R253Q; 4:20488965-20488965	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2986G>A; p.E996K; 4:20568902-20568902	skin	malignant_melanoma	Substitution - Missense
c.2986G>A; p.E996K; 4:20568902-20568902	skin	malignant_melanoma	Substitution - Missense
c.796_797CC>TT; p.P266F; 4:20491781-20491782	skin; scalp	malignant_melanoma	Substitution - Missense
c.4170G>A; p.A1390A; 4:20617472-20617472	ovary	other; neoplasm	Substitution - coding silent
c.161C>G; p.P54R; 4:20253976-20253976	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4013A>T; p.K1338M; 4:20617075-20617075	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3625G>T; p.E1209*; 4:20598328-20598328	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1819A>G; p.S607G; 4:20533702-20533702	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2442A>T; p.R814S; 4:20549081-20549081	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.784T>C; p.S262P; 4:20491769-20491769	skin	malignant_melanoma	Substitution - Missense
c.2487A>T; p.L829F; 4:20549126-20549126	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1506G>A; p.A502A; 4:20528992-20528992	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1008C>A; p.I336I; 4:20511087-20511087	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3745G>A; p.D1249N; 4:20610065-20610065	skin	malignant_melanoma	Substitution - Missense
c.1263C>T; p.A421A; 4:20523892-20523892	skin	malignant_melanoma	Substitution - coding silent
c.3296C>T; p.T1099M; 4:20595810-20595810	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1047T>C; p.S349S; 4:20511126-20511126	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.4512C>T; p.F1504F; 4:20618931-20618931	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.4512C>T; p.F1504F; 4:20618931-20618931	skin	malignant_melanoma	Substitution - coding silent
c.3502G>A; p.E1168K; 4:20596596-20596596	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.4512C>T; p.F1504F; 4:20618931-20618931	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.4512C>T; p.F1504F; 4:20618931-20618931	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1233C>T; p.I411I; 4:20523862-20523862	skin	malignant_melanoma	Substitution - coding silent
c.3245_3247delACA; p.N1083delN; 4:20595759-20595761	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.4512C>T; p.F1504F; 4:20618931-20618931	skin	malignant_melanoma	Substitution - coding silent
c.1118C>T; p.S373F; 4:20519441-20519441	skin	malignant_melanoma	Substitution - Missense
c.1118C>T; p.S373F; 4:20519441-20519441	skin	malignant_melanoma	Substitution - Missense
c.1118C>T; p.S373F; 4:20519441-20519441	skin	malignant_melanoma	Substitution - Missense
c.1770G>A; p.T590T; 4:20533653-20533653	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2851-1G>A; p.?; 4:20567517-20567517	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1118C>T; p.S373F; 4:20519441-20519441	skin	malignant_melanoma	Substitution - Missense
c.4485G>T; p.L1495L; 4:20618904-20618904	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1118C>T; p.S373F; 4:20519441-20519441	skin	malignant_melanoma	Substitution - Missense
c.1118C>T; p.S373F; 4:20519441-20519441	skin	malignant_melanoma	Substitution - Missense
c.1770G>A; p.T590T; 4:20533653-20533653	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1307G>T; p.C436F; 4:20524046-20524046	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1511T>A; p.L504Q; 4:20528997-20528997	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.790A>G; p.M264V; 4:20491775-20491775	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4348G>T; p.E1450*; 4:20617650-20617650	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.4577G>C; p.R1526T; 4:20618996-20618996	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.134C>T; p.A45V; 4:20253949-20253949	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1048C>G; p.L350V; 4:20511127-20511127	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2777C>T; p.P926L; 4:20567313-20567313	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.213G>A; p.T71T; 4:20256705-20256705	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2777C>T; p.P926L; 4:20567313-20567313	skin; neck	malignant_melanoma	Substitution - Missense
c.2373G>A; p.T791T; 4:20548515-20548515	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1572C>G; p.L524L; 4:20529058-20529058	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.213G>A; p.T71T; 4:20256705-20256705	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3262G>A; p.G1088R; 4:20595776-20595776	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.489C>T; p.I163I; 4:20480737-20480737	oesophagus	carcinoma	Substitution - coding silent
c.144C>G; p.S48R; 4:20253959-20253959	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1261G>A; p.A421T; 4:20523890-20523890	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1621A>G; p.N541D; 4:20531991-20531991	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1585G>C; p.E529Q; 4:20529071-20529071	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2659G>C; p.A887P; 4:20553902-20553902	thyroid	carcinoma	Substitution - Missense
c.3397G>T; p.G1133*; 4:20596491-20596491	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.324-1G>A; p.?; 4:20268809-20268809	skin; trunk	malignant_melanoma	Unknown
c.1250C>T; p.S417L; 4:20523879-20523879	skin	malignant_melanoma	Substitution - Missense
c.1205C>T; p.S402F; 4:20523834-20523834	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4574C>T; p.T1525M; 4:20618993-20618993	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3345A>C; p.P1115P; 4:20596439-20596439	breast	carcinoma	Substitution - coding silent
c.520C>T; p.L174F; 4:20480768-20480768	skin	malignant_melanoma	Substitution - Missense
c.3297G>A; p.T1099T; 4:20595811-20595811	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2482C>T; p.R828*; 4:20549121-20549121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2128T>C; p.F710L; 4:20541604-20541604	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2482C>T; p.R828*; 4:20549121-20549121	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1796A>G; p.H599R; 4:20533679-20533679	pancreas	carcinoma	Substitution - Missense
c.2482C>T; p.R828*; 4:20549121-20549121	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2482C>T; p.R828*; 4:20549121-20549121	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2482C>T; p.R828*; 4:20549121-20549121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2818T>G; p.F940V; 4:20567354-20567354	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2754G>A; p.K918K; 4:20567290-20567290	pancreas	carcinoma	Substitution - coding silent
c.914T>C; p.I305T; 4:20491899-20491899	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2628G>A; p.S876S; 4:20553871-20553871	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.3561+2T>A; p.?; 4:20596657-20596657	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.3336G>C; p.E1112D; 4:20596430-20596430	skin	malignant_melanoma	Substitution - Missense
c.3634C>T; p.R1212W; 4:20598337-20598337	skin	malignant_melanoma	Substitution - Missense
c.3419T>A; p.I1140K; 4:20596513-20596513	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3634C>T; p.R1212W; 4:20598337-20598337	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.914T>C; p.I305T; 4:20491899-20491899	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3634C>T; p.R1212W; 4:20598337-20598337	skin	malignant_melanoma	Substitution - Missense
c.3138C>A; p.P1046P; 4:20589693-20589693	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.3397_3398GG>AA; p.G1133K; 4:20596491-20596492	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2372C>T; p.T791M; 4:20548514-20548514	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2372C>T; p.T791M; 4:20548514-20548514	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.278C>T; p.T93I; 4:20257894-20257894	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1830T>G; p.T610T; 4:20533713-20533713	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2948+4G>A; p.?; 4:20567619-20567619	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Unknown
c.2995G>A; p.V999I; 4:20568911-20568911	pancreas	carcinoma	Substitution - Missense
c.1126C>T; p.L376F; 4:20519449-20519449	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4353C>A; p.I1451I; 4:20618772-20618772	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2995G>A; p.V999I; 4:20568911-20568911	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.992T>C; p.L331P; 4:20511071-20511071	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2562-3C>T; p.?; 4:20553802-20553802	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.4298A>G; p.Q1433R; 4:20617600-20617600	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.191G>A; p.G64E; 4:20256683-20256683	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3361C>T; p.R1121C; 4:20596455-20596455	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4121C>A; p.P1374H; 4:20617183-20617183	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.566G>T; p.R189I; 4:20486226-20486226	breast	carcinoma	Substitution - Missense
c.2234T>G; p.L745W; 4:20542584-20542584	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.4121C>A; p.P1374H; 4:20617183-20617183	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4220A>G; p.D1407G; 4:20617522-20617522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.180-1G>C; p.?; 4:20256671-20256671	oesophagus	carcinoma; adenocarcinoma	Unknown
c.1422G>T; p.K474N; 4:20524161-20524161	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3777G>A; p.G1259G; 4:20610097-20610097	skin	malignant_melanoma	Substitution - coding silent
c.3781C>A; p.P1261T; 4:20610101-20610101	pancreas	carcinoma	Substitution - Missense
c.4463G>A; p.G1488E; 4:20618882-20618882	skin	malignant_melanoma	Substitution - Missense
c.3781C>A; p.P1261T; 4:20610101-20610101	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.3276A>C; p.T1092T; 4:20595790-20595790	thyroid	other; neoplasm	Substitution - coding silent
c.628A>C; p.N210H; 4:20488835-20488835	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3348C>G; p.P1116P; 4:20596442-20596442	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1015_1016insT; p.A340fs*20; 4:20511094-20511095	autonomic_ganglia	neuroblastoma	Insertion - Frameshift
c.610T>G; p.F204V; 4:20486270-20486270	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3331T>G; p.C1111G; 4:20596425-20596425	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3820A>G; p.N1274D; 4:20610140-20610140	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3612C>T; p.D1204D; 4:20598315-20598315	skin	malignant_melanoma	Substitution - coding silent
c.4272G>A; p.G1424G; 4:20617574-20617574	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.4068C>G; p.C1356W; 4:20617130-20617130	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.35C>T; p.S12L; 4:20253850-20253850	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.4390A>C; p.K1464Q; 4:20618809-20618809	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3032C>A; p.S1011Y; 4:20568948-20568948	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3646C>T; p.R1216C; 4:20598349-20598349	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3032C>A; p.S1011Y; 4:20568948-20568948	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3573T>A; p.D1191E; 4:20598276-20598276	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.630C>T; p.N210N; 4:20488837-20488837	skin	malignant_melanoma	Substitution - coding silent
c.2019T>C; p.A673A; 4:20541495-20541495	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1749T>A; p.G583G; 4:20533632-20533632	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.4370G>A; p.R1457K; 4:20618789-20618789	skin	malignant_melanoma	Substitution - Missense
c.3085A>G; p.T1029A; 4:20569001-20569001	liver	carcinoma	Substitution - Missense
c.4553A>T; p.K1518I; 4:20618972-20618972	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3593T>G; p.L1198R; 4:20598296-20598296	skin	malignant_melanoma	Substitution - Missense
c.4C>T; p.R2C; 4:20253819-20253819	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4C>T; p.R2C; 4:20253819-20253819	pancreas	carcinoma	Substitution - Missense
c.2160T>C; p.S720S; 4:20542510-20542510	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.4C>T; p.R2C; 4:20253819-20253819	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2892C>T; p.N964N; 4:20567559-20567559	skin	malignant_melanoma	Substitution - coding silent
c.4C>T; p.R2C; 4:20253819-20253819	breast	carcinoma	Substitution - Missense
c.4513G>A; p.E1505K; 4:20618932-20618932	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4513G>A; p.E1505K; 4:20618932-20618932	skin	malignant_melanoma	Substitution - Missense
c.1053T>C; p.N351N; 4:20511132-20511132	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1829C>T; p.T610I; 4:20533712-20533712	central_nervous_system; thalamus	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2977G>A; p.E993K; 4:20568893-20568893	skin	malignant_melanoma	Substitution - Missense
c.656G>T; p.W219L; 4:20488863-20488863	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.602T>G; p.L201R; 4:20486262-20486262	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1046C>T; p.S349F; 4:20511125-20511125	skin	malignant_melanoma	Substitution - Missense
c.3200G>A; p.G1067E; 4:20595714-20595714	skin	malignant_melanoma	Substitution - Missense
c.4378G>T; p.D1460Y; 4:20618797-20618797	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1694T>G; p.F565C; 4:20533577-20533577	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4299G>A; p.Q1433Q; 4:20617601-20617601	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.4333G>C; p.D1445H; 4:20617635-20617635	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.300G>T; p.Q100H; 4:20257916-20257916	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2700T>A; p.T900T; 4:20553943-20553943	skin	malignant_melanoma	Substitution - coding silent
c.25C>T; p.L9L; 4:20253840-20253840	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1777C>T; p.R593C; 4:20533660-20533660	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1777C>T; p.R593C; 4:20533660-20533660	skin	malignant_melanoma	Substitution - Missense
c.2726-1G>A; p.?; 4:20567261-20567261	stomach	carcinoma; adenocarcinoma	Unknown
c.1777C>T; p.R593C; 4:20533660-20533660	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2700T>A; p.T900T; 4:20553943-20553943	skin	malignant_melanoma	Substitution - coding silent
c.3769G>A; p.D1257N; 4:20610089-20610089	skin	malignant_melanoma	Substitution - Missense
c.1178A>G; p.Q393R; 4:20523807-20523807	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2144G>A; p.G715E; 4:20542494-20542494	skin	malignant_melanoma	Substitution - Missense
c.2144G>A; p.G715E; 4:20542494-20542494	skin	malignant_melanoma	Substitution - Missense
c.2144G>A; p.G715E; 4:20542494-20542494	skin	malignant_melanoma	Substitution - Missense
c.2144G>A; p.G715E; 4:20542494-20542494	skin	malignant_melanoma	Substitution - Missense
c.2782A>T; p.K928*; 4:20567318-20567318	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.4557G>A; p.V1519V; 4:20618976-20618976	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.4418C>G; p.T1473R; 4:20618837-20618837	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3157T>A; p.C1053S; 4:20589712-20589712	breast	carcinoma	Substitution - Missense
c.3230T>G; p.F1077C; 4:20595744-20595744	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1126C>A; p.L376I; 4:20519449-20519449	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1126C>A; p.L376I; 4:20519449-20519449	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.751C>G; p.Q251E; 4:20488958-20488958	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2007C>T; p.N669N; 4:20541483-20541483	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1966T>G; p.L656V; 4:20539574-20539574	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3226G>A; p.D1076N; 4:20595740-20595740	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.1084G>A; p.E362K; 4:20519407-20519407	skin	malignant_melanoma	Substitution - Missense
c.468-10T>G; p.?; 4:20480706-20480706	stomach	carcinoma; diffuse_adenocarcinoma	Unknown
c.1507G>T; p.D503Y; 4:20528993-20528993	breast	carcinoma	Substitution - Missense
c.164G>A; p.R55H; 4:20253979-20253979	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3119G>A; p.C1040Y; 4:20589674-20589674	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1866G>A; p.G622G; 4:20539474-20539474	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.510A>G; p.A170A; 4:20480758-20480758	liver	carcinoma	Substitution - coding silent
c.1897C>T; p.R633C; 4:20539505-20539505	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1131-3C>A; p.?; 4:20523757-20523757	liver	carcinoma	Unknown
c.2623A>G; p.K875E; 4:20553866-20553866	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.613C>T; p.R205*; 4:20488820-20488820	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3136C>T; p.P1046S; 4:20589691-20589691	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.569T>G; p.L190R; 4:20486229-20486229	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1213G>A; p.D405N; 4:20523842-20523842	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1217A>G; p.N406S; 4:20523846-20523846	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2513C>T; p.S838F; 4:20550850-20550850	skin	malignant_melanoma	Substitution - Missense
c.3892G>A; p.G1298R; 4:20616954-20616954	skin	malignant_melanoma	Substitution - Missense
c.658C>T; p.L220F; 4:20488865-20488865	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1055C>T; p.S352L; 4:20511134-20511134	skin	malignant_melanoma	Substitution - Missense
c.2110G>A; p.D704N; 4:20541586-20541586	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3546G>A; p.T1182T; 4:20596640-20596640	skin	malignant_melanoma	Substitution - coding silent
c.3546G>A; p.T1182T; 4:20596640-20596640	skin	malignant_melanoma	Substitution - coding silent
c.2144-8C>T; p.?; 4:20542486-20542486	prostate	carcinoma	Unknown
c.4041G>A; p.Q1347Q; 4:20617103-20617103	central_nervous_system; brain	glioma	Substitution - coding silent
c.1177C>T; p.Q393*; 4:20523806-20523806	skin	malignant_melanoma	Substitution - Nonsense
c.3819G>A; p.L1273L; 4:20610139-20610139	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2165C>T; p.S722F; 4:20542515-20542515	skin	malignant_melanoma	Substitution - Missense
c.3411C>T; p.I1137I; 4:20596505-20596505	skin	malignant_melanoma	Substitution - coding silent
c.4387C>G; p.Q1463E; 4:20618806-20618806	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2165C>T; p.S722F; 4:20542515-20542515	skin	malignant_melanoma	Substitution - Missense
c.1693T>A; p.F565I; 4:20533576-20533576	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1424A>C; p.K475T; 4:20524163-20524163	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3446C>T; p.P1149L; 4:20596540-20596540	central_nervous_system; brain	glioma	Substitution - Missense
c.1289A>C; p.N430T; 4:20524028-20524028	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.4134T>A; p.N1378K; 4:20617196-20617196	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.704A>G; p.Q235R; 4:20488911-20488911	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3900C>G; p.N1300K; 4:20616962-20616962	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.910G>A; p.E304K; 4:20491895-20491895	skin	malignant_melanoma	Substitution - Missense
c.4542C>T; p.D1514D; 4:20618961-20618961	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1470A>G; p.E490E; 4:20528956-20528956	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.825C>T; p.A275A; 4:20491810-20491810	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2406G>T; p.Q802H; 4:20548548-20548548	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1470A>G; p.E490E; 4:20528956-20528956	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1645G>A; p.E549K; 4:20532015-20532015	skin	malignant_melanoma	Substitution - Missense
c.2048G>T; p.R683I; 4:20541524-20541524	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.828C>T; p.A276A; 4:20491813-20491813	skin	malignant_melanoma	Substitution - coding silent
c.2048G>T; p.R683I; 4:20541524-20541524	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3112G>A; p.D1038N; 4:20589667-20589667	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2048G>T; p.R683I; 4:20541524-20541524	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4003C>T; p.P1335S; 4:20617065-20617065	breast	carcinoma	Substitution - Missense
c.3379A>T; p.N1127Y; 4:20596473-20596473	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.163C>T; p.R55C; 4:20253978-20253978	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2714T>G; p.F905C; 4:20553957-20553957	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1036G>A; p.G346R; 4:20511115-20511115	skin	malignant_melanoma	Substitution - Missense
c.3801G>C; p.L1267F; 4:20610121-20610121	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3135C>A; p.N1045K; 4:20589690-20589690	skin	malignant_melanoma	Substitution - Missense
c.2702C>T; p.P901L; 4:20553945-20553945	skin	malignant_melanoma	Substitution - Missense
c.1437A>T; p.S479S; 4:20524176-20524176	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1428C>T; p.F476F; 4:20524167-20524167	skin	malignant_melanoma	Substitution - coding silent
c.212C>T; p.T71M; 4:20256704-20256704	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.212C>T; p.T71M; 4:20256704-20256704	pancreas	carcinoma	Substitution - Missense
c.1478G>A; p.R493Q; 4:20528964-20528964	skin	malignant_melanoma	Substitution - Missense
c.3063A>G; p.T1021T; 4:20568979-20568979	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1948delT; p.F650fs*10; 4:20539556-20539556	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1428C>T; p.F476F; 4:20524167-20524167	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1400G>A; p.R467K; 4:20524139-20524139	skin	malignant_melanoma	Substitution - Missense
c.1478G>A; p.R493Q; 4:20528964-20528964	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.917G>T; p.R306L; 4:20510497-20510497	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.212C>T; p.T71M; 4:20256704-20256704	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1478G>A; p.R493Q; 4:20528964-20528964	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3905C>A; p.T1302N; 4:20616967-20616967	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1062C>T; p.V354V; 4:20519385-20519385	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.4421C>T; p.T1474I; 4:20618840-20618840	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3619G>A; p.A1207T; 4:20598322-20598322	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2057C>G; p.T686R; 4:20541533-20541533	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.809T>C; p.V270A; 4:20491794-20491794	skin	malignant_melanoma	Substitution - Missense
c.2722C>T; p.Q908*; 4:20553965-20553965	skin	malignant_melanoma	Substitution - Nonsense
c.2747_2748TA>CT; p.L916P; 4:20567283-20567284	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3344C>T; p.P1115L; 4:20596438-20596438	skin	malignant_melanoma	Substitution - Missense
c.809T>C; p.V270A; 4:20491794-20491794	skin	malignant_melanoma	Substitution - Missense
c.3172A>G; p.K1058E; 4:20589727-20589727	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.4325A>T; p.Y1442F; 4:20617627-20617627	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.335G>T; p.R112I; 4:20268821-20268821	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1455C>A; p.F485L; 4:20525165-20525165	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.747G>A; p.E249E; 4:20488954-20488954	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1859G>T; p.C620F; 4:20539467-20539467	breast	carcinoma	Substitution - Missense
c.4408G>T; p.A1470S; 4:20618827-20618827	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.381G>C; p.A127A; 4:20268867-20268867	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.4008C>T; p.C1336C; 4:20617070-20617070	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.4207G>T; p.G1403C; 4:20617509-20617509	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2851-4C>G; p.?; 4:20567514-20567514	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Unknown
c.3341C>A; p.S1114Y; 4:20596435-20596435	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2625G>T; p.K875N; 4:20553868-20553868	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3137C>T; p.P1046L; 4:20589692-20589692	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2836C>A; p.P946T; 4:20567372-20567372	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.674G>A; p.R225H; 4:20488881-20488881	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.674G>A; p.R225H; 4:20488881-20488881	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.674G>A; p.R225H; 4:20488881-20488881	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1206C>T; p.S402S; 4:20523835-20523835	skin	malignant_melanoma	Substitution - coding silent
c.2645G>A; p.G882E; 4:20553888-20553888	skin	malignant_melanoma	Substitution - Missense
c.4085G>A; p.W1362*; 4:20617147-20617147	skin; mucosal	malignant_melanoma	Substitution - Nonsense
c.4085G>A; p.W1362*; 4:20617147-20617147	skin	malignant_melanoma	Substitution - Nonsense
c.2205T>A; p.D735E; 4:20542555-20542555	ovary	other; neoplasm	Substitution - Missense
c.2981A>G; p.N994S; 4:20568897-20568897	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1659C>A; p.I553I; 4:20532029-20532029	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2205T>A; p.D735E; 4:20542555-20542555	ovary	other; neoplasm	Substitution - Missense
c.171C>A; p.T57T; 4:20253986-20253986	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.3233A>G; p.D1078G; 4:20595747-20595747	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3081G>T; p.E1027D; 4:20568997-20568997	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.793G>A; p.A265T; 4:20491778-20491778	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1455C>T; p.F485F; 4:20525165-20525165	skin	malignant_melanoma	Substitution - coding silent
c.4204G>A; p.G1402R; 4:20617506-20617506	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1887C>T; p.L629L; 4:20539495-20539495	breast	carcinoma	Substitution - coding silent
c.3835C>A; p.L1279I; 4:20610155-20610155	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2681A>G; p.D894G; 4:20553924-20553924	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1034A>T; p.Q345L; 4:20511113-20511113	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.892C>A; p.L298I; 4:20491877-20491877	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.933A>C; p.T311T; 4:20510513-20510513	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.78G>T; p.Q26H; 4:20253893-20253893	thyroid	other; neoplasm	Substitution - Missense
c.3690C>A; p.Y1230*; 4:20598393-20598393	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.431G>T; p.R144M; 4:20467787-20467787	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1581C>T; p.I527I; 4:20529067-20529067	skin	malignant_melanoma	Substitution - coding silent
c.2594G>T; p.C865F; 4:20553837-20553837	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.290G>C; p.G97A; 4:20257906-20257906	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.4222G>A; p.E1408K; 4:20617524-20617524	skin	malignant_melanoma	Substitution - Missense
c.4346G>A; p.R1449Q; 4:20617648-20617648	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4346G>A; p.R1449Q; 4:20617648-20617648	skin	malignant_melanoma	Substitution - Missense
c.2435G>A; p.R812H; 4:20549074-20549074	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.681G>T; p.R227S; 4:20488888-20488888	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4355C>T; p.S1452F; 4:20618774-20618774	skin	malignant_melanoma	Substitution - Missense
c.2435G>A; p.R812H; 4:20549074-20549074	large_intestine; caecum	adenoma	Substitution - Missense
c.4346G>A; p.R1449Q; 4:20617648-20617648	skin	malignant_melanoma	Substitution - Missense
c.24G>C; p.M8I; 4:20253839-20253839	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.256C>T; p.L86F; 4:20257872-20257872	thyroid	carcinoma	Substitution - Missense
c.4130G>A; p.G1377E; 4:20617192-20617192	skin	malignant_melanoma	Substitution - Missense
c.3044A>G; p.D1015G; 4:20568960-20568960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1618C>T; p.L540F; 4:20531988-20531988	breast	carcinoma	Substitution - Missense
c.4395G>A; p.Q1465Q; 4:20618814-20618814	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.4282C>T; p.L1428F; 4:20617584-20617584	skin	malignant_melanoma	Substitution - Missense
c.3353T>C; p.V1118A; 4:20596447-20596447	breast	carcinoma	Substitution - Missense
c.1921C>A; p.Q641K; 4:20539529-20539529	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.590A>T; p.H197L; 4:20486250-20486250	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1290C>G; p.N430K; 4:20524029-20524029	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.4195G>A; p.E1399K; 4:20617497-20617497	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1726G>A; p.G576R; 4:20533609-20533609	skin	malignant_melanoma	Substitution - Missense
c.1726G>A; p.G576R; 4:20533609-20533609	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.996C>T; p.S332S; 4:20511075-20511075	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.4195G>A; p.E1399K; 4:20617497-20617497	skin	malignant_melanoma	Substitution - Missense
c.4194G>A; p.L1398L; 4:20617496-20617496	skin	malignant_melanoma	Substitution - coding silent
c.2596A>T; p.N866Y; 4:20553839-20553839	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3693-7G>A; p.?; 4:20610006-20610006	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.3036A>T; p.T1012T; 4:20568952-20568952	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2492C>A; p.S831Y; 4:20550829-20550829	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1485A>T; p.K495N; 4:20528971-20528971	pancreas	carcinoma	Substitution - Missense
c.3611A>T; p.D1204V; 4:20598314-20598314	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2706_2707insA; p.F905fs*14; 4:20553949-20553950	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.933A>G; p.T311T; 4:20510513-20510513	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1650C>A; p.A550A; 4:20532020-20532020	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2021G>A; p.W674*; 4:20541497-20541497	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Nonsense
c.4065C>T; p.T1355T; 4:20617127-20617127	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2815G>T; p.D939Y; 4:20567351-20567351	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4044C>T; p.P1348P; 4:20617106-20617106	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.3988T>G; p.L1330V; 4:20617050-20617050	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3126G>C; p.Q1042H; 4:20589681-20589681	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1308C>T; p.C436C; 4:20524047-20524047	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.4270G>T; p.G1424W; 4:20617572-20617572	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.4523A>G; p.D1508G; 4:20618942-20618942	skin	malignant_melanoma	Substitution - Missense
c.2598C>A; p.N866K; 4:20553841-20553841	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3693-7G>T; p.?; 4:20610006-20610006	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1609G>A; p.E537K; 4:20529095-20529095	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1837T>C; p.L613L; 4:20539445-20539445	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.868G>A; p.G290S; 4:20491853-20491853	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2177G>A; p.R726H; 4:20542527-20542527	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.4534T>C; p.F1512L; 4:20618953-20618953	skin	malignant_melanoma	Substitution - Missense
c.3321T>C; p.S1107S; 4:20596415-20596415	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1529G>T; p.C510F; 4:20529015-20529015	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1637C>T; p.T546I; 4:20532007-20532007	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2668G>C; p.G890R; 4:20553911-20553911	breast	carcinoma	Substitution - Missense
c.2642C>A; p.P881H; 4:20553885-20553885	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.4345C>T; p.R1449*; 4:20617647-20617647	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.826G>A; p.A276T; 4:20491811-20491811	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.145G>A; p.V49M; 4:20253960-20253960	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3460G>A; p.E1154K; 4:20596554-20596554	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.145G>A; p.V49M; 4:20253960-20253960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.145G>A; p.V49M; 4:20253960-20253960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3032C>T; p.S1011F; 4:20568948-20568948	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4575G>A; p.T1525T; 4:20618994-20618994	skin	malignant_melanoma	Substitution - coding silent
c.2422C>T; p.L808F; 4:20549061-20549061	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2202G>A; p.L734L; 4:20542552-20542552	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.4575G>A; p.T1525T; 4:20618994-20618994	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.4575G>A; p.T1525T; 4:20618994-20618994	breast	carcinoma	Substitution - coding silent
c.2960C>T; p.A987V; 4:20568876-20568876	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.4445G>T; p.C1482F; 4:20618864-20618864	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.644G>A; p.C215Y; 4:20488851-20488851	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3901G>A; p.G1301R; 4:20616963-20616963	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4160C>G; p.P1387R; 4:20617462-20617462	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1407A>G; p.G469G; 4:20524146-20524146	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2581C>T; p.L861F; 4:20553824-20553824	skin	malignant_melanoma	Substitution - Missense
c.1194G>T; p.L398F; 4:20523823-20523823	large_intestine	adenoma	Substitution - Missense
c.3310G>A; p.E1104K; 4:20595824-20595824	skin	malignant_melanoma	Substitution - Missense
c.1297A>G; p.I433V; 4:20524036-20524036	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.747G>T; p.E249D; 4:20488954-20488954	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1907C>G; p.S636C; 4:20539515-20539515	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4129G>A; p.G1377R; 4:20617191-20617191	skin	malignant_melanoma	Substitution - Missense
c.3263G>A; p.G1088E; 4:20595777-20595777	skin	malignant_melanoma	Substitution - Missense
c.1384C>T; p.R462C; 4:20524123-20524123	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.226delG; p.A76fs*6; 4:20256718-20256718	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3916G>T; p.G1306C; 4:20616978-20616978	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.3334G>T; p.E1112*; 4:20596428-20596428	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.3916G>T; p.G1306C; 4:20616978-20616978	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.3169C>T; p.P1057S; 4:20589724-20589724	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.899A>T; p.E300V; 4:20491884-20491884	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.395+7A>G; p.?; 4:20268888-20268888	pancreas	carcinoma	Unknown
c.3130C>T; p.L1044L; 4:20589685-20589685	skin	malignant_melanoma	Substitution - coding silent
c.2810C>T; p.P937L; 4:20567346-20567346	skin	malignant_melanoma	Substitution - Missense
c.1162C>T; p.R388W; 4:20523791-20523791	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3288C>T; p.N1096N; 4:20595802-20595802	pancreas	carcinoma	Substitution - coding silent
c.131T>G; p.L44R; 4:20253946-20253946	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.915A>G; p.I305M; 4:20510495-20510495	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.429A>T; p.P143P; 4:20467785-20467785	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2705_2706CC>TT; p.S902F; 4:20553948-20553949	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3730G>T; p.E1244*; 4:20610050-20610050	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1304A>T; p.D435V; 4:20524043-20524043	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2324A>G; p.N775S; 4:20546078-20546078	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2324A>G; p.N775S; 4:20546078-20546078	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2380A>T; p.N794Y; 4:20548522-20548522	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.576G>T; p.V192V; 4:20486236-20486236	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.3110T>C; p.L1037P; 4:20589665-20589665	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.2925G>T; p.K975N; 4:20567592-20567592	oesophagus	carcinoma	Substitution - Missense
c.1343A>G; p.N448S; 4:20524082-20524082	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4436G>A; p.R1479Q; 4:20618855-20618855	skin; trunk	malignant_melanoma	Substitution - Missense
c.1572_1574delCAA; p.N525delN; 4:20529058-20529060	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.1998T>C; p.F666F; 4:20541474-20541474	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.3412G>A; p.V1138I; 4:20596506-20596506	breast	carcinoma	Substitution - Missense
c.4436G>A; p.R1479Q; 4:20618855-20618855	skin	malignant_melanoma	Substitution - Missense
c.4499G>A; p.R1500Q; 4:20618918-20618918	skin	malignant_melanoma	Substitution - Missense
c.1198C>A; p.L400I; 4:20523827-20523827	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4348+1G>T; p.?; 4:20617651-20617651	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.4188G>T; p.K1396N; 4:20617490-20617490	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.4499G>A; p.R1500Q; 4:20618918-20618918	skin	malignant_melanoma	Substitution - Missense
c.1316A>T; p.K439M; 4:20524055-20524055	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3835C>G; p.L1279V; 4:20610155-20610155	skin	malignant_melanoma	Substitution - Missense
c.4499G>A; p.R1500Q; 4:20618918-20618918	skin	malignant_melanoma	Substitution - Missense
c.3383T>C; p.F1128S; 4:20596477-20596477	skin	malignant_melanoma	Substitution - Missense
c.576G>A; p.V192V; 4:20486236-20486236	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.3684C>T; p.A1228A; 4:20598387-20598387	lung	carcinoma; adenocarcinoma	Substitution - coding silent

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]