| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 9516 |
Name | LITAF |
Synonymous | lipopolysaccharide-induced TNF factor;LITAF;lipopolysaccharide-induced TNF factor |
Definition | LPS-induced TNF-alpha factor|lipopolysaccharide-induced TNF-alpha factor|lipopolysaccharide-induced tumor necrosis factor-alpha factor|p53-induced gene 7 protein|small integral membrane protein of lysosome/late endosome|tumor protein p53 inducible protein |
Position | 16p13.13 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.22. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.66C>T; p.S22S; 16:11556665-11556665 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.370C>A; p.L124M; 16:11553540-11553540 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.190C>A; p.Q64K; 16:11556541-11556541 |
skin; ear | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.180G>A; p.S60S; 16:11556551-11556551 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.180G>A; p.S60S; 16:11556551-11556551 |
autonomic_ganglia | neuroblastoma | Substitution - coding silent |
c.101C>A; p.P34H; 16:11556630-11556630 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.214A>T; p.N72Y; 16:11556517-11556517 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.324delC; p.Y109fs*6; 16:11553586-11553586 |
liver | carcinoma; hepatocellular_carcinoma | Deletion - Frameshift |
c.324delC; p.Y109fs*6; 16:11553586-11553586 |
liver | carcinoma; hepatocellular_carcinoma | Deletion - Frameshift |
c.411C>T; p.C137C; 16:11549712-11549712 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.415G>T; p.D139Y; 16:11549708-11549708 |
lung | carcinoma; small_cell_carcinoma | Substitution - Missense |
c.42C>A; p.S14S; 16:11556689-11556689 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.51_59delATCCGCACC; p.S18_P20delSAP; 16:11556672-11556680 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Deletion - In frame |
c.454A>G; p.R152G; 16:11549669-11549669 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.359G>A; p.G120E; 16:11553551-11553551 |
kidney | other; neoplasm | Substitution - Missense |
c.226G>A; p.V76M; 16:11553684-11553684 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.136G>T; p.G46W; 16:11556595-11556595 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.372G>A; p.L124L; 16:11553538-11553538 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.240C>T; p.Y80Y; 16:11553670-11553670 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.309C>T; p.I103I; 16:11553601-11553601 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |