Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

9788

Name

MTSS1

Synonymous

metastasis suppressor 1;MTSS1;metastasis suppressor 1

Definition

metastasis suppressor YGL-1|metastasis suppressor protein 1|missing in metastasis protein

Position

8p22

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.09.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1916A>G; p.E639G; 8:124553344-124553344

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.2183G>A; p.G728E; 8:124553077-124553077

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1141C>T; p.R381W; 8:124557770-124557770

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1093G>A; p.G365S; 8:124557818-124557818

 skinmalignant_melanomaSubstitution - Missense

c.1520C>T; p.T507I; 8:124555789-124555789

 breastcarcinomaSubstitution - Missense

c.565A>G; p.I189V; 8:124568432-124568432

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.565A>G; p.I189V; 8:124568432-124568432

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1983C>A; p.P661P; 8:124553277-124553277

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.565A>G; p.I189V; 8:124568432-124568432

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1649G>C; p.R550T; 8:124553611-124553611

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.99C>T; p.F33F; 8:124704165-124704165

 skinmalignant_melanomaSubstitution - coding silent

c.459_460insA; p.G154fs*4; 8:124585087-124585088

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.618+2T>C; p.?; 8:124568377-124568377

 lungcarcinoma; adenocarcinomaUnknown

c.1283G>A; p.R428H; 8:124556353-124556353

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1733G>A; p.G578E; 8:124553527-124553527

 skinmalignant_melanomaSubstitution - Missense

c.1798C>T; p.R600C; 8:124553462-124553462

 pancreascarcinoma; acinar_carcinomaSubstitution - Missense

c.1798C>T; p.R600C; 8:124553462-124553462

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1798C>T; p.R600C; 8:124553462-124553462

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1918C>T; p.R640W; 8:124553342-124553342

 breastcarcinomaSubstitution - Missense

c.1400C>A; p.T467N; 8:124556236-124556236

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1918C>T; p.R640W; 8:124553342-124553342

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1638C>A; p.S546S; 8:124553622-124553622

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.240C>T; p.T80T; 8:124591204-124591204

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.168C>T; p.D56D; 8:124699566-124699566

 breastcarcinomaSubstitution - coding silent

c.2129G>A; p.G710D; 8:124553131-124553131

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2217G>A; p.V739V; 8:124553043-124553043

 parathyroidcarcinomaSubstitution - coding silent

c.294C>A; p.S98R; 8:124589711-124589711

 breastcarcinomaSubstitution - Missense

c.40G>T; p.G14C; 8:124727916-124727916

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.759C>T; p.S253S; 8:124565727-124565727

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.873C>G; p.H291Q; 8:124562944-124562944

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1015C>T; p.P339S; 8:124562802-124562802

 skinmalignant_melanomaSubstitution - Missense

c.1804G>A; p.G602R; 8:124553456-124553456

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1804G>A; p.G602R; 8:124553456-124553456

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.773C>T; p.T258M; 8:124565713-124565713

 prostatecarcinomaSubstitution - Missense

c.773C>T; p.T258M; 8:124565713-124565713

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2173A>G; p.T725A; 8:124553087-124553087

 thyroidother; neoplasmSubstitution - Missense

c.1332C>T; p.T444T; 8:124556304-124556304

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1769G>A; p.R590Q; 8:124553491-124553491

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1769G>A; p.R590Q; 8:124553491-124553491

 central_nervous_system; brainglioma; oligodendroglioma_Grade_IIISubstitution - Missense

c.1867G>A; p.V623I; 8:124553393-124553393

 stomachcarcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiableSubstitution - Missense

c.2132A>G; p.Q711R; 8:124553128-124553128

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.984T>C; p.D328D; 8:124562833-124562833

 thyroidother; neoplasmSubstitution - coding silent

c.899G>A; p.R300H; 8:124562918-124562918

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.423C>A; p.S141S; 8:124585124-124585124

 skinmalignant_melanomaSubstitution - coding silent

c.745G>A; p.G249S; 8:124565741-124565741

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1883G>T; p.G628V; 8:124553377-124553377

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.2196G>A; p.L732L; 8:124553064-124553064

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.935T>C; p.V312A; 8:124562882-124562882

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1842C>T; p.P614P; 8:124553418-124553418

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1967G>T; p.G656V; 8:124553293-124553293

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1998C>T; p.S666S; 8:124553262-124553262

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.401G>A; p.R134H; 8:124585146-124585146

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.212G>T; p.G71V; 8:124591232-124591232

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1187T>C; p.I396T; 8:124557724-124557724

 bone; extraskeletalEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.266T>C; p.I89T; 8:124591178-124591178

 livercarcinomaSubstitution - Missense

c.2215G>A; p.V739M; 8:124553045-124553045

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1045G>A; p.G349R; 8:124557866-124557866

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1805G>A; p.G602E; 8:124553455-124553455

 skinmalignant_melanomaSubstitution - Missense

c.1017G>A; p.P339P; 8:124562800-124562800

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1906G>A; p.G636R; 8:124553354-124553354

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1718T>C; p.L573P; 8:124553542-124553542

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.114A>G; p.G38G; 8:124704150-124704150

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.834_835delCA; p.N278fs*6; 8:124562982-124562983

 stomachcarcinoma; adenocarcinomaDeletion - Frameshift

c.216C>A; p.T72T; 8:124591228-124591228

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.938G>T; p.R313M; 8:124562879-124562879

 NSmalignant_melanomaSubstitution - Missense

c.1293G>T; p.E431D; 8:124556343-124556343

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1153G>A; p.V385I; 8:124557758-124557758

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.938G>T; p.R313M; 8:124562879-124562879

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.1377G>A; p.R459R; 8:124556259-124556259

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1915G>A; p.E639K; 8:124553345-124553345

 skinmalignant_melanomaSubstitution - Missense

c.400C>T; p.R134C; 8:124585147-124585147

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1972A>G; p.T658A; 8:124553288-124553288

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1959C>T; p.G653G; 8:124553301-124553301

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1959C>T; p.G653G; 8:124553301-124553301

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.2234C>T; p.T745M; 8:124553026-124553026

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2234C>T; p.T745M; 8:124553026-124553026

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.608G>A; p.R203Q; 8:124568389-124568389

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.608G>A; p.R203Q; 8:124568389-124568389

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.501A>C; p.Q167H; 8:124568496-124568496

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1537T>C; p.C513R; 8:124555772-124555772

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1828C>A; p.P610T; 8:124553432-124553432

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.957C>A; p.S319S; 8:124562860-124562860

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.580C>T; p.R194*; 8:124568417-124568417

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.2118T>G; p.T706T; 8:124553142-124553142

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.290C>T; p.S97L; 8:124591154-124591154

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1339G>A; p.G447S; 8:124556297-124556297

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.2114C>T; p.A705V; 8:124553146-124553146

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.426G>A; p.S142S; 8:124585121-124585121

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.2115C>A; p.A705A; 8:124553145-124553145

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1394C>T; p.A465V; 8:124556242-124556242

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.2168G>A; p.R723K; 8:124553092-124553092

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.345G>A; p.W115*; 8:124589660-124589660

 skin; trunkmalignant_melanomaSubstitution - Nonsense

c.94G>T; p.D32Y; 8:124704170-124704170

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.417G>T; p.K139N; 8:124585130-124585130

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1206G>A; p.P402P; 8:124557705-124557705

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.2000G>A; p.G667D; 8:124553260-124553260

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2000G>A; p.G667D; 8:124553260-124553260

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.716C>G; p.S239*; 8:124567081-124567081

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.276G>T; p.K92N; 8:124591168-124591168

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.966A>T; p.S322S; 8:124562851-124562851

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.2192T>G; p.M731R; 8:124553068-124553068

 livercarcinomaSubstitution - Missense

c.2192T>G; p.M731R; 8:124553068-124553068

 livercarcinomaSubstitution - Missense

c.1657G>A; p.D553N; 8:124553603-124553603

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2192T>G; p.M731R; 8:124553068-124553068

 livercarcinomaSubstitution - Missense

c.2125C>A; p.P709T; 8:124553135-124553135

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.2192T>G; p.M731R; 8:124553068-124553068

 livercarcinomaSubstitution - Missense

c.205C>T; p.R69C; 8:124699529-124699529

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.205C>T; p.R69C; 8:124699529-124699529

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.517T>C; p.Y173H; 8:124568480-124568480

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.517T>C; p.Y173H; 8:124568480-124568480

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.2144G>A; p.S715N; 8:124553116-124553116

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1317G>T; p.G439G; 8:124556319-124556319

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1169A>T; p.Y390F; 8:124557742-124557742

 pancreascarcinomaSubstitution - Missense

c.1352C>T; p.A451V; 8:124556284-124556284

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.801G>A; p.M267I; 8:124565685-124565685

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.379G>A; p.A127T; 8:124589626-124589626

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1316G>A; p.G439E; 8:124556320-124556320

 skinmalignant_melanomaSubstitution - Missense

c.1614T>A; p.D538E; 8:124553646-124553646

 skinmalignant_melanomaSubstitution - Missense

c.151G>T; p.A51S; 8:124699583-124699583

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.41G>T; p.G14V; 8:124727915-124727915

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.268G>T; p.E90*; 8:124591176-124591176

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1374A>T; p.P458P; 8:124556262-124556262

 livercarcinomaSubstitution - coding silent

c.1374A>T; p.P458P; 8:124556262-124556262

 livercarcinomaSubstitution - coding silent

c.2069T>A; p.I690N; 8:124553191-124553191

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.566T>C; p.I189T; 8:124568431-124568431

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1130G>A; p.R377H; 8:124557781-124557781

 pancreascarcinomaSubstitution - Missense

c.566T>C; p.I189T; 8:124568431-124568431

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.898C>T; p.R300C; 8:124562919-124562919

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.911C>G; p.S304C; 8:124562906-124562906

 breastcarcinomaSubstitution - Missense

c.134G>A; p.R45Q; 8:124704130-124704130

 skinmalignant_melanomaSubstitution - Missense

c.792C>T; p.S264S; 8:124565694-124565694

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.792C>T; p.S264S; 8:124565694-124565694

 breastcarcinomaSubstitution - coding silent

c.1676G>A; p.R559Q; 8:124553584-124553584

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.459delA; p.R155fs*34; 8:124585088-124585088

 stomachadenocarcinomaDeletion - Frameshift

c.459delA; p.R155fs*34; 8:124585088-124585088

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.459delA; p.R155fs*34; 8:124585088-124585088

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.459delA; p.R155fs*34; 8:124585088-124585088

 livercarcinomaDeletion - Frameshift

c.459delA; p.R155fs*34; 8:124585088-124585088

 stomachcarcinoma; intestinal_adenocarcinomaDeletion - Frameshift

c.1247G>T; p.G416V; 8:124556389-124556389

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1138C>T; p.P380S; 8:124557773-124557773

 skinmalignant_melanomaSubstitution - Missense

c.875C>A; p.S292*; 8:124562942-124562942

 ovaryother; neoplasmSubstitution - Nonsense

c.403C>G; p.Q135E; 8:124585144-124585144

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.819C>G; p.V273V; 8:124565667-124565667

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.1741A>G; p.M581V; 8:124553519-124553519

 livercarcinomaSubstitution - Missense

')