Entrez Gene

Basic Information
Gene ID	10019
Name	SH2B3
Synonymous	IDDM20\|LNK;SH2B adaptor protein 3;SH2B3;SH2B adaptor protein 3
Definition	SH2B adapter protein 3\|lymphocyte-specific adapter protein Lnk\|signal transduction protein Lnk
Position	12q24
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
Lnk(h) + ATP --Lck(h)--> Lnk(h){p} + ADP (phosphorylation)
CD3zeta(h){p} + Lnk(h) <==> CD3zeta(h){p}:Lnk(h) (binding)
Lnk(h) + ABP-280(h) <==> Lnk(h):ABP-280(h) (binding)
Lnk(h) + ABP-280(mo) <==> Lnk(h):ABP-280(mo) (binding)
LNK(h) --> Lnk(h) (expression).
ErbB1-p170(h){pY998} + Lnk(h) <==> ErbB1-p170(h){pY998}:Lnk(h) (binding)
ErbB2(h){pY1222} + Lnk(h) <==> ErbB2(h){pY1222}:Lnk(h) (binding)
ErbB3-isoform1(h){pY1289} + Lnk(h) <==> ErbB3-isoform1(h){pY1289}:Lnk(h) (binding)
ErbB4(h){pY1284} + Lnk(h) <==> ErbB4(h){pY1284}:Lnk(h) (binding)
LNK(h) --> Lnk(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
273	Phosphotyrosine (Lck;ZAP70)	9169414	Phospho.ELM 6.0