| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 10273 |
Name | STUB1 |
Synonymous | CHIP|HSPABP2|NY-CO-7|SCAR16|SDCCAG7|UBOX1;STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase;STUB1;STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase |
Definition | CLL-associated antigen KW-8|E3 ubiquitin-protein ligase CHIP|antigen NY-CO-7|carboxy terminus of Hsp70-interacting protein|heat shock protein A binding protein 2 (c-terminal)|serologically defined colon cancer antigen 7 |
Position | 16p13.3 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
Pael-R(h) + CHIP(h) <==> Pael-R(h):CHIP(h) (binding) | parkin(h) + CHIP(h) <==> parkin(h):CHIP(h) (binding) | CHIP(h) + Pael-R(h){ub(n)} <==> CHIP(h):Pael-R(h){ub(n)} (binding) | AR(h) + CHIP(h) <==> AR(h):CHIP(h) (binding) | CHIP(h) + ER-alpha(m.s.) <==> CHIP(h):ER-alpha(m.s.) (binding) | CHIP(h) + ER-alpha(h) <==> CHIP(h):ER-alpha(h) (binding) | CHIP(h) --> ER-alpha(h) (degradation) | Hsc70(h) + CHIP(h) <==> Hsc70(h):CHIP(h) (binding) | ErbB2(h) + CHIP(h) <==> ErbB2(h):CHIP(h) (binding) | ER-alpha-L(h) + CHIP(h) <==> ER-alpha-L(h):CHIP(h) (binding) | CHIP(h) + p53(h) <==> CHIP(h):p53(h) (binding) | p53-isoform1(h) + CHIP(h) <==> p53-isoform1(h):CHIP(h) (binding) | CHIP(h) + Sam68(h) <==> CHIP(h):Sam68(h) (binding) | CHIP(h) --/ SMAD2(h) (transrepression) | CHIP(h) --/ Smad2(h) (decrease of abundance) | CHIP(h) --/ TWIST(h) (decrease of abundance) | CHIP(h) --/ Bcl-2(h) (decrease of abundance) | CHIP(h) --/ AKT-1(h) (decrease of abundance) | CHIP(h) --/ beta-catenin(h) (decrease of abundance) | CHIP(h) --/ vimentin(h) (decrease of abundance) | CHIP(h) --/ TWIST1(h) (transrepression) | CHIP(h) --/ BCL2(h) (transrepression) | CHIP(h) --/ AKT1(h) (transrepression) | CHIP(h) --/ CTNNB1(h) (transrepression) | CHIP(h) --/ VIM(h) (transrepression) | SRC3(h) + CHIP(h) <==> SRC3(h):CHIP(h) (binding) | CHIP(h) --/ IGF1(h) (transrepression) | CHIP(h) --/ IGF-1(h) (decrease of abundance) | STUB1(h) --> CHIP(h) (expression). | bag1(h) + ubiquitin(h) --E1(rb),Ubc5B(h),CHIP(h)--> bag1(h){ub} (ubiquitination) | bag1(h) + 2 ubiquitin(h) --E1(rb),Ubc5B(h),CHIP(h)--> bag1(h){ub(2)} (ubiquitination) | bag1(h) + n ubiquitin(h) --CHIP(h)--> bag1(h){ub(n)K11} (ubiquitination) | bag1(h) + n ubiquitin(h) --Ubc5B(h),CHIP(h),Hsc70(r),Hsp40(h)--> bag1(h){ub(n)K11} (ubiquitination) | Hsc70(r) + n ubiquitin(r) --Ubc5B(h),CHIP(h)--> Hsc70(r){ub(n)} (ubiquitination) | AR-isoform1(h) + CHIP(h) <==> AR-isoform1(h):CHIP(h) (binding) | AR-isoform1(h){pT103} + CHIP(h) <==> AR-isoform1(h){pT103}:CHIP(h) (binding) | AR-isoform1(h){pY357}{pY362}{pY363} + CHIP(h) <==> AR-isoform1(h){pY357}{pY362}{pY363}:CHIP(h) (binding) | AR-isoform1(h){pY530}{pY534} + CHIP(h) <==> AR-isoform1(h){pY530}{pY534}:CHIP(h) (binding) | AR-isoform1(h){pS647}{pT648}{pS650}{pT655}{pT656} + CHIP(h) <==> AR-isoform1(h){pS647}{pT648}{pS650}{pT655}{pT656}:CHIP(h) (binding) | AR-isoform1(h){pS662}{pY667} + CHIP(h) <==> AR-isoform1(h){pS662}{pY667}:CHIP(h) (binding) | AR-isoform1(h){pS791}{pT800} + CHIP(h) <==> AR-isoform1(h){pS791}{pT800}:CHIP(h) (binding) | AR-isoform1(h){pS256} + CHIP(h) <==> AR-isoform1(h){pS256}:CHIP(h) (binding) | CHIP(h) + ubiquitin(h) --Ubc5A(m.s.),E1(m.s.)--> CHIP(h){ub} (ubiquitination) | CHIP(h) --/ ErbB2(h) (decrease of abundance) | CHIP(h) + Hsp70-1(h) <==> CHIP(h):Hsp70-1(h) (binding) | Hsp90(h) + CHIP(h) <==> Hsp90(h):CHIP(h) (binding) | CHIP(h) + ErbB2(h) <==> CHIP(h):ErbB2(h) (binding) | parkin-isoform1(h) + LIMK1-isoform1(h) + CHIP(h) <==> parkin-isoform1(h):LIMK1-isoform1(h):CHIP(h) (binding) | LIMK1-isoform1(h) + CHIP(h) <==> LIMK1-isoform1(h):CHIP(h) (binding) | Ubc5A(h) + CHIP(h) <==> Ubc5A(h):CHIP(h) (binding) | CHIP(h) + Ubc13(h) <==> CHIP(h):Ubc13(h) (binding) | CHIP(h) + n ubiquitin(h) --Ubc5B(h)--> CHIP(h){ub}n (ubiquitination) | CHIP(h) + ubiquitin(h) --UBE2E2(h)--> CHIP(h){ub}n (ubiquitination; automodification) | p53-isoform1(h) + CHIP(h) <==> p53-isoform1(h):CHIP(h) (binding) | STUB1(h) --> CHIP(h) (expression). | ErbB2(h) + ubiquitin(h) --CHIP(h)--> ErbB2(h){ub} (ubiquitination) |
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Post Transcriptional Modification [Top] | |||
There is no record for STUB1 | |||
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr16 |
Promoter: 668616 - 670616 | Agilent_014791 |
chr16 |
Promoter: 668616 - 670616 | GSE27584 |
chr16 |
Promoter: 668616 - 670616 | Agilent_014791_44K |