| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 1147 |
Name | CHUK |
Synonymous | IKBKA|IKK-alpha|IKK1|IKKA|NFKBIKA|TCF16;conserved helix-loop-helix ubiquitous kinase;CHUK;conserved helix-loop-helix ubiquitous kinase |
Definition | I-kappa-B kinase 1|I-kappa-B kinase-alpha|IKK-a kinase|IkB kinase alpha subunit|Nuclear factor NFkappaB inhibitor kinase alpha|TCF-16|inhibitor of nuclear factor kappa-B kinase subunit alpha|transcription factor 16 |
Position | 10q24-q25 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
NIK(h) + IKK-alpha(h) <==> NIK(h):IKK-alpha(h) (binding) | TAK1(m) + NIK(h) + IKK-alpha(h) <==> TAK1(m):NIK(h):IKK-alpha(h) (binding) | TNFR1(h) + IKK-alpha(h) <==> TNFR1(h):IKK-alpha(h) (binding) | IKK-gamma(h) + IKK-beta(h) + IKK-alpha(h) <==> IKK-alpha(h):IKK-beta(h):(IKK-gamma(h))2 (binding) | IKK-alpha(h) + IKK-beta(h) <==> IKK-alpha(h):IKK-beta(h) (binding) | TAK1a(h) + IKK-alpha(h) <==> TAK1a(h):IKK-alpha(h) (binding) | RKIP(r) + IKK-alpha(h) <==> RKIP(r):IKK-alpha(h) (binding) | IKK-alpha(h) + MEKK1(r) <==> IKK-alpha(h):MEKK1(r) (binding) | IKK-alpha(h) + ATP --MEKK1(h)--> IKK-alpha(h){p} + ADP (phosphorylation) | PKCalpha(b) + IKK-alpha(h) <==> PKCalpha(b):IKK-alpha(h) (binding) | PKCzeta(r) + IKK-alpha(h) <==> PKCzeta(r):IKK-alpha(h) (binding) | PKCiota(x) + IKK-alpha(h) <==> PKCiota(x):IKK-alpha(h) (binding) | IKK-alpha(h) + IKK-gamma(m) <==> IKK-alpha(h):IKK-gamma(m) (binding) | IKK-i(h) + TANK(h) + IKK-alpha(h) <==> IKK-i(h):TANK(h):IKK-alpha(h) (binding) | TANK(h) + IKK-alpha(h) <==> TANK(h):IKK-alpha(h) (binding) | IKK-alpha(h) + ATP --> IKK-alpha(h){pY} + ADP (phosphorylation) | Src(h) + IKK-alpha(h) <==> Src(h):IKK-alpha(h) (binding) | Ro52(h) + IKK-gamma(h) + IKK-beta(h) + IKK-alpha(h) + CBP(h) + TIF2(h) + SRC3(h) <==> Ro52(h):IKK-gamma(h):IKK-beta(h):IKK-alpha(h):CBP(h):TIF2(h):SRC3(h) (binding) | IKK-alpha(h) + SRC3(h) <==> IKK-alpha(h):SRC3(h) (binding) | IKK-alpha(h) --> E2F1(h) (transactivation) | IKK-alpha(h) --> tk1(h) (transactivation) | IKK-alpha(h) --> PCNA(h) (transactivation) | IKK-alpha(h) --> cdc25A(h) (transactivation) | IKK-alpha(h) --> cycE(h) (transactivation) | IKK-alpha(h) --> E2F-1(h) (increase of abundance) | IKK-alpha(h) --> TK1(h) (increase of abundance) | IKK-alpha(h) --> pRb(h) (increase of abundance) | IKK-alpha(h) --> cyclinD1(h) (increase of abundance) | E2F-1(h) + IKK-alpha(h) <==> E2F-1(h):IKK-alpha(h) (binding) | IKK-gamma(h) + IKK-beta(h) + IKK-alpha(h) + Hsp50(h) + Hsp90(h) <==> IKK-gamma(h):IKK-beta(h):IKK-alpha(h):Hsp50(h):Hsp90(h) (binding) | IKK-alpha(h) + TAK1(h) <==> IKK-alpha(h):TAK1(h) (binding) | IKK-alpha(h) --> IKK-alpha(h) (translocation) | CBP(h) + IKK-alpha(h) <==> CBP(h):IKK-alpha(h) (binding) | IKK-alpha(h) + p73(h) <==> IKK-alpha(h):p73(h) (binding) | IKK-alpha(h) + IKK-gamma(m) <==> IKK-alpha(h):IKK-gamma(m) (binding) | IKK-alpha(h) + 2 ATP --> IKK-alpha(h){pS176}{pS180} + 2 ADP (phosphorylation) | TRAF6(h) + IKK-alpha(h) <==> TRAF6(h):IKK-alpha(h) (binding) | IKAP(h) + RelA-p65(h) + NIK(h) + IKK-beta(h) + IKK-alpha(h) <==> IKAP(h):RelA-p65(h):NIK(h):IKK-beta(h):IKK-alpha(h) (binding) | IKK-alpha(h) + TAB2-isoform1(h) <==> IKK-alpha(h):TAB2-isoform1(h) (binding) | IKK-alpha(h) --> IKK-alpha(h) (translocation) | IKK-alpha(h) + ATP --> IKK-alpha(h){p} + ADP (phosphorylation) | PKCdelta(h) + IKK-alpha(h) <==> PKCdelta(h):IKK-alpha(h) (binding) | p53(h) + IKK-alpha(h) <==> p53(h):IKK-alpha(h) (binding) | IKK-gamma(h) + IKK-alpha(h) + IKK-beta(h) <==> IKK-gamma(h):IKK-alpha(h):IKK-beta(h) (binding) | IKK-alpha(h) + 3 ATP --> IKK-alpha(h){pT23}{pS176}{pS180} + 3 ADP (phosphorylation) | IKK-alpha(h) + AKT(h) <==> IKK-alpha(h):AKT(h) (binding) | IKK-alpha(h) + NF-kappaB2-p100(h) <==> IKK-alpha(h):NF-kappaB2-p100(h) (binding) | p100(m.s.) + IKK-alpha(h) <==> p100(m.s.):IKK-alpha(h) (binding) | IKK-alpha(h) --> p53(h) (increase of abundance) | IKK-alpha(h) + 2 ATP --NIK(m.s.)--> IKK-alpha(h){pS176}{pS180} + 2 ADP (phosphorylation) | IKK-gamma(h) + IKK-beta(h) + IKK-alpha(h) + CIKS(h) <==> IKK-gamma(h):IKK-beta(h):IKK-alpha(h):CIKS(h) (binding) | IRAK1(h) + IKK-alpha(h) <==> IRAK1(h):IKK-alpha(h) (binding) | IKK-alpha(h) + CARD11(h) <==> IKK-alpha(h):CARD11(h) (binding) | IKK-alpha(h) + ATP --> IKK-alpha(h){pS180} + ADP (phosphorylation) | IKK-alpha(h) + IkappaB-alpha(m.s.) <==> IKK-alpha(h):IkappaB-alpha(m.s.) (binding) | CHUK(h) --> IKK-alpha(h) (expression). | TAK1(h) --/ IKK-alpha(h) (decrease of abundance) | IKK-alpha(h) --> IKK-alpha(h) (translocation) | IKK-alpha(h) --> IKK-alpha(h) (translocation) | UHX1(h) --> IKK-alpha(h) (increase of abundance) | IkappaB-alpha(h) + ATP --IKK-alpha(h)--> IkappaB-alpha(h){p} + ADP (phosphorylation) | CBP(m.s.) + 2 ATP --IKK-alpha(h)--> CBP(m.s.){pS1382}{pS1386} + 2 ADP (phosphorylation) | CBP(h) + 2 ATP --IKK-alpha(h)--> CBP(h){pS1382}{pS1386} + 2 ADP (phosphorylation) | p53(h) + ATP --IKK-alpha(h)--> p53(h){pS20} + ADP (phosphorylation) | IkappaB-alpha(m.s.) + ATP --IKK-alpha(h)--> IkappaB-alpha(m.s.){pS32} + ADP (phosphorylation) | IkappaB-alpha(m.s.) + ATP --IKK-alpha(h)--> IkappaB-alpha(m.s.){p} + ADP (phosphorylation) | IKK-alpha(h) --> E2F-1(m.s.){ace} (increase of acetylation) | IKK-alpha(h) + 2 ATP --> IKK-alpha(h){pS176}{pS180} + 2 ADP (phosphorylation) | IKK-alpha(h) + ATP --> IKK-alpha(h){p} + ADP (phosphorylation; automodification) | IKK-alpha(h) + NIBP(m) <==> IKK-alpha(h):NIBP(m) (binding) | STAP2(h) + IKK-alpha(h) <==> STAP2(h):IKK-alpha(h) (binding) | IKK-gamma(h) + IKK-alpha(h) <==> IKK-gamma(h):IKK-alpha(h) (binding) | Hsp50(h) + IKK-alpha(h) <==> Hsp50(h):IKK-alpha(h) (binding) | IKK-alpha(h) + Hsp90(h) <==> IKK-alpha(h):Hsp90(h) (binding) | CIKS(h) + IKK-alpha(h) <==> CIKS(h):IKK-alpha(h) (binding) | CHUK(h) --> IKK-alpha(h) (expression). | RelA-p65(h) + ATP --IKK-alpha(h)--> RelA-p65(h){pS536} + ADP (phosphorylation) | RelA-p65(h):SMRT(m.s.) + 2 ATP --IKK-alpha(h)--> RelA-p65(h){pS536} + SMRT(m.s.){pS2410} + ADP (dissociation; phosphorylation) | Hsp50(h) + ATP --IKK-alpha(h)--> Hsp50(h){pS300} + ADP (phosphorylation) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
23 | Phosphothreonine (by PKB/AKT1). | Swiss-Prot 53.0 | 176 | Phosphoserine (by MAP3K14). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr10 |
Promoter: 101978834 - 101980834 | Agilent_014791 |
chr10 |
Promoter: 101978834 - 101980834 | GSE27584 |
chr10 |
Promoter: 101978834 - 101980834 | Agilent_014791_44K |