| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1390 |
Name | CREM |
Synonymous | CREM-2|ICER|hCREM-2;cAMP responsive element modulator;CREM;cAMP responsive element modulator |
Definition | CREM 2alpha-b protein|CREM 2beta-a protein|cAMP response element modulator|cAMP-responsive element modulator|inducible cAMP early repressor ICER |
Position | 10p11.21 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
There is no record for CREM | |||
Transcription Factors [Top] |
|
Regulation From TransFac database |
|---|
| ICER-II(h) --> ICER(m) (DNA binding). |
| ICER-II(h) --/ CCL4(h) (DNA binding; transrepression). |
| CREM(h) --> ICER-II(h) (expression). |
| ICER-IIgamma(h) --> ICER(m) (DNA binding). |
| CREM(h) --> ICER-IIgamma(h) (expression). |
| CREMalpha(h) --> CCNA2(h) (DNA binding). |
| CREMalpha(h) --> CCND1(h) (DNA binding; transactivation). |
| CREMalpha(h) --> SP-B(rb) (DNA binding). |
| CREM(h) --> CREMalpha(h) (expression). |
| CREM(h) --> FOS(h) (DNA binding). |
| CBP(h) + CREM(h) <==> CBP(h):CREM(h) (binding) |
| CREM(h) --> CD1A(h) (DNA binding). |
| CREM(h) --> Sst(r) (DNA binding). |
| CREM(h) --> INS(h) (DNA binding). |
| CREM(h) --> MMP1(h) (DNA binding). |
| CREM(h) --> CGA(h) (DNA binding). |
| CREM(h) --> DIO2(h) (DNA binding). |
| CREM(h) --> CREM(h) (expression). |
| ATF-1(h) + CREM-Ia(h) <==> ATF-1(h):CREM-Ia(h) (binding) |
| 2 CREM-Ia(h) <==> (CREM-Ia(h))2 (oligomerization) |
| ICER-xbb1(h) + CREM-Ia(h) <==> ICER-xbb1(h):CREM-Ia(h) (binding) |
| CREM-Ib(h) + CREM-Ia(h) <==> CREM-Ib(h):CREM-Ia(h) (binding) |
| CREB1(h) + CREM-Ia(h) <==> CREB1(h):CREM-Ia(h) (binding) |
| OASIS(h) + CREM-Ia(h) <==> OASIS(h):CREM-Ia(h) (binding) |
| E4BP4(h) + CREM-Ia(h) <==> E4BP4(h):CREM-Ia(h) (binding) |
| CREM-Ia(h) + Bach1(h) <==> CREM-Ia(h):Bach1(h) (binding) |
| CREM(h) --> CREM-Ia(h) (expression). |
| ATF-1(h) + CREM-Ib(h) <==> ATF-1(h):CREM-Ib(h) (binding) |
| CREM-Ib(h) + CREM-Ia(h) <==> CREM-Ib(h):CREM-Ia(h) (binding) |
| CREM-Ib(h) + ICER-xbb1(h) <==> CREM-Ib(h):ICER-xbb1(h) (binding) |
| 2 CREM-Ib(h) <==> (CREM-Ib(h))2 (oligomerization) |
| CREB1(h) + CREM-Ib(h) <==> CREB1(h):CREM-Ib(h) (binding) |
| CREM(h) --> CREM-Ib(h) (expression). |
| ICER-xbb1(h) + ATF-1(h) <==> ICER-xbb1(h):ATF-1(h) (binding) |
| ICER-xbb1(h) + CREM-Ia(h) <==> ICER-xbb1(h):CREM-Ia(h) (binding) |
| 2 ICER-xbb1(h) <==> (ICER-xbb1(h))2 (oligomerization) |
| CREM-Ib(h) + ICER-xbb1(h) <==> CREM-Ib(h):ICER-xbb1(h) (binding) |
| CREB1(h) + ICER-xbb1(h) <==> CREB1(h):ICER-xbb1(h) (binding) |
| OASIS(h) + ICER-xbb1(h) <==> OASIS(h):ICER-xbb1(h) (binding) |
| E4BP4(h) + ICER-xbb1(h) <==> E4BP4(h):ICER-xbb1(h) (binding) |
| CREM(h) --> ICER-xbb1(h) (expression). |
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
|---|---|---|---|
| 116 | Phosphoserine | 8404858 | Phospho.ELM 6.0 |
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr10 |
Promoter: 35454894 - 35456894 | Agilent_014791 |
chr10 |
Promoter: 35465216 - 35467216 | Agilent_014791 |
chr10 |
Promoter: 35454307 - 35456307 | GSE27584 |
chr10 |
Promoter: 35454307 - 35456307 | GSE27584 |
chr10 |
Promoter: 35454307 - 35456307 | GSE27584 |
chr10 |
Promoter: 35454894 - 35456894 | GSE27584 |
chr10 |
Promoter: 35454894 - 35456894 | GSE27584 |
chr10 |
Promoter: 35454307 - 35456307 | GSE27584 |