Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1390

Name

CREM

Synonymous

CREM-2|ICER|hCREM-2;cAMP responsive element modulator;CREM;cAMP responsive element modulator

Definition

CREM 2alpha-b protein|CREM 2beta-a protein|cAMP response element modulator|cAMP-responsive element modulator|inducible cAMP early repressor ICER

Position

10p11.21

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

There is no record for CREM

Transcription Factors   [Top]

Regulation From TransFac database

ICER-II(h) --> ICER(m) (DNA binding).
ICER-II(h) --/ CCL4(h) (DNA binding; transrepression).
CREM(h) --> ICER-II(h) (expression).
ICER-IIgamma(h) --> ICER(m) (DNA binding).
CREM(h) --> ICER-IIgamma(h) (expression).
CREMalpha(h) --> CCNA2(h) (DNA binding).
CREMalpha(h) --> CCND1(h) (DNA binding; transactivation).
CREMalpha(h) --> SP-B(rb) (DNA binding).
CREM(h) --> CREMalpha(h) (expression).
CREM(h) --> FOS(h) (DNA binding).
CBP(h) + CREM(h) <==> CBP(h):CREM(h) (binding)
CREM(h) --> CD1A(h) (DNA binding).
CREM(h) --> Sst(r) (DNA binding).
CREM(h) --> INS(h) (DNA binding).
CREM(h) --> MMP1(h) (DNA binding).
CREM(h) --> CGA(h) (DNA binding).
CREM(h) --> DIO2(h) (DNA binding).
CREM(h) --> CREM(h) (expression).
ATF-1(h) + CREM-Ia(h) <==> ATF-1(h):CREM-Ia(h) (binding)
2 CREM-Ia(h) <==> (CREM-Ia(h))2 (oligomerization)
ICER-xbb1(h) + CREM-Ia(h) <==> ICER-xbb1(h):CREM-Ia(h) (binding)
CREM-Ib(h) + CREM-Ia(h) <==> CREM-Ib(h):CREM-Ia(h) (binding)
CREB1(h) + CREM-Ia(h) <==> CREB1(h):CREM-Ia(h) (binding)
OASIS(h) + CREM-Ia(h) <==> OASIS(h):CREM-Ia(h) (binding)
E4BP4(h) + CREM-Ia(h) <==> E4BP4(h):CREM-Ia(h) (binding)
CREM-Ia(h) + Bach1(h) <==> CREM-Ia(h):Bach1(h) (binding)
CREM(h) --> CREM-Ia(h) (expression).
ATF-1(h) + CREM-Ib(h) <==> ATF-1(h):CREM-Ib(h) (binding)
CREM-Ib(h) + CREM-Ia(h) <==> CREM-Ib(h):CREM-Ia(h) (binding)
CREM-Ib(h) + ICER-xbb1(h) <==> CREM-Ib(h):ICER-xbb1(h) (binding)
2 CREM-Ib(h) <==> (CREM-Ib(h))2 (oligomerization)
CREB1(h) + CREM-Ib(h) <==> CREB1(h):CREM-Ib(h) (binding)
CREM(h) --> CREM-Ib(h) (expression).
ICER-xbb1(h) + ATF-1(h) <==> ICER-xbb1(h):ATF-1(h) (binding)
ICER-xbb1(h) + CREM-Ia(h) <==> ICER-xbb1(h):CREM-Ia(h) (binding)
2 ICER-xbb1(h) <==> (ICER-xbb1(h))2 (oligomerization)
CREM-Ib(h) + ICER-xbb1(h) <==> CREM-Ib(h):ICER-xbb1(h) (binding)
CREB1(h) + ICER-xbb1(h) <==> CREB1(h):ICER-xbb1(h) (binding)
OASIS(h) + ICER-xbb1(h) <==> OASIS(h):ICER-xbb1(h) (binding)
E4BP4(h) + ICER-xbb1(h) <==> E4BP4(h):ICER-xbb1(h) (binding)
CREM(h) --> ICER-xbb1(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

116Phosphoserine8404858Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr10

Promoter: 35454894 - 35456894Agilent_014791

chr10

Promoter: 35465216 - 35467216Agilent_014791

chr10

Promoter: 35454307 - 35456307GSE27584

chr10

Promoter: 35454307 - 35456307GSE27584

chr10

Promoter: 35454307 - 35456307GSE27584

chr10

Promoter: 35454894 - 35456894GSE27584

chr10

Promoter: 35454894 - 35456894GSE27584

chr10

Promoter: 35454307 - 35456307GSE27584


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