| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 1437 |
Name | CSF2 |
Synonymous | GMCSF;colony stimulating factor 2 (granulocyte-macrophage);CSF2;colony stimulating factor 2 (granulocyte-macrophage) |
Definition | CSF|granulocyte macrophage-colony stimulating factor|granulocyte-macrophage colony-stimulating factor|molgramostin|sargramostim |
Position | 5q31.1 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
There is no record for CSF2 | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
CSF2(h) --> GM-CSF(h) (expression). | ULBP1(m.s.) --> GM-CSF(h) (increase of abundance) | MICA(m.s.) --> GM-CSF(h) (increase of abundance) | CD154(m.s.) --> GM-CSF(h) (increase of abundance) | IL-17F(h) --> GM-CSF(h) (increase of secretion) | TNF-alpha(m.s.) --> GM-CSF(h) (increase of secretion) | GM-CSF(h) --> Src(h){p} (increase of phosphorylation) | GM-CSF(h) --> AKT(h){p} (increase of phosphorylation) | GM-CSF(h) --> ERK(h){p} (increase of phosphorylation) | GM-CSF(h) --> Jak2(h){p} (increase of phosphorylation) | GM-CSF(h) --> STAT5(h){p} (increase of phosphorylation) | GM-CSF(h) --> STAT3(h){p} (increase of phosphorylation) | GM-CSF(h) --> Hck(h){p} (increase of phosphorylation) | GM-CSF(h) --> IL-5Rbeta(h){pY} (increase of phosphorylation) | GM-CSF(h) --> Jak1(h){pY} (increase of phosphorylation) | GM-CSF(h) --> Jak2(h){pY} (increase of phosphorylation) | GM-CSF(h) --> p38(h){p} (increase of phosphorylation) | GM-CSF(h) --> p38alpha(h){p} (increase of phosphorylation) | GM-CSF(h) --> ERK1(h){p} (increase of phosphorylation) | GM-CSF(h) --> ERK2(h){p} (increase of phosphorylation) | GM-CSF(h) --> TLR2(h) (transactivation) | GM-CSF(h) --/ TLR5(h) (transrepression) | GM-CSF(h) --> TLR4(h) (transactivation) | GM-CSF(h) --> TLR9(h) (transactivation) | GM-CSF(h) --> AKT-1(h){pS473} (increase of phosphorylation) | GM-CSF(h) --> JNK2alpha-1(h){p} (increase of phosphorylation) | GM-CSF(h) --> JNK2(h){p} (increase of phosphorylation) | GM-CSF(h) --> Bim(h){p} (increase of phosphorylation) | GM-CSF(h) --> IL-5Rbeta-isoform1(h){pS601} (increase of phosphorylation) | GM-CSF(h) --> IL-5Rbeta-isoform1(h){pY593} (increase of phosphorylation) | GM-CSF(h) --> p85(m):IL-5Rbeta-isoform1(h){pS601}:14-3-3zeta(m) (increase of binding) | GM-CSF(h) --> ERK(m){p} (increase of phosphorylation) | GM-CSF(h) --> AKT(m){p} (increase of phosphorylation) | GM-CSF(h) --> STAT5(m){p} (increase of phosphorylation) | GM-CSF(h) --> Jak2(m){p} (increase of phosphorylation) | GM-CSF(h) --> IL-5Rbeta-isoform1(h){pY} (increase of phosphorylation) | GM-CSF(h) --> Ras(m):GTP:Raf-1(m.s.) (increase of binding) | GM-CSF(h) --> Bcl2(m) (transactivation) | GM-CSF(h) --> BCL2L1(m) (transactivation) | GM-CSF(h) --> Pim1(m) (transactivation) | GM-CSF(h) --> SHP-2(m){pY} (increase of phosphorylation) | GM-CSF(h) --> Shc(m){pY} (increase of phosphorylation) | GM-CSF(h) --> ERK2(m){p} (increase of phosphorylation) | GM-CSF(h) --> ERK1(m){p} (increase of phosphorylation) | GM-CSF(h) + IL-5Rbeta-isoform1(h) <==> GM-CSF(h):IL-5Rbeta-isoform1(h) (binding) | GM-CSF(h) --> STAT5A(h){pY694} (increase of phosphorylation) | GM-CSF(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | GM-CSF(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | GM-CSF(h) --> p38alpha(h){pT180}{pY182} (increase of phosphorylation) | GM-CSF(h) --> Lyn(h){pY} (increase of phosphorylation) | GM-CSF(h) --> STAT5A(h){pY} (increase of phosphorylation) | GM-CSF(h) --> Jak2(m.s.){pY} (increase of phosphorylation) | GM-CSF(h) --> Shc-1(m){pY} (increase of phosphorylation) | GM-CSF(h) --> FOS(h) (transactivation) | GM-CSF(h) --> Jak2(m){pY} (increase of phosphorylation) | GM-CSF(h) --> SHP-2(m){pY}:Grb-2(m) (increase of binding) | GM-CSF(h) --> Raf-1(m){p} (increase of phosphorylation) | GM-CSF(h) --> STAT5(m){pY} (increase of phosphorylation) | GM-CSF(h) --> c-Jun(m.s.){pY} (increase of phosphorylation) | GM-CSF(h) --> SOCS1(h) (transactivation) | CSF2(h) --> GM-CSF(h) (expression). |
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Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
22 | O-linked (GalNAc...). | Swiss-Prot 53.0 | 24 | O-linked (GalNAc...). | Swiss-Prot 53.0 | 26 | O-linked (GalNAc...). | Swiss-Prot 53.0 | 27 | O-linked (GalNAc...); partial. | Swiss-Prot 53.0 | 44 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 54 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 22 | O-linked | Kaushansky, K., Lopez, J., and Brown, C. (1992)Biochemistry, 31, 1881-1886. Medline: 92144609; | OGlycBase6.0 | 24 | O-linked | Kaushansky, K., Lopez, J., and Brown, C. (1992)Biochemistry, 31, 1881-1886. Medline: 92144609; | OGlycBase6.0 | 26 | O-linked | Kaushansky, K., Lopez, J., and Brown, C. (1992)Biochemistry, 31, 1881-1886. Medline: 92144609; | OGlycBase6.0 | 27 | O-linked | Kaushansky, K., Lopez, J., and Brown, C. (1992)Biochemistry, 31, 1881-1886. Medline: 92144609; | OGlycBase6.0 | 257 | O-linked | Kaushansky, K., Lopez, J., and Brown, C. (1992)Biochemistry, 31, 1881-1886. Medline: 92144609; | OGlycBase6.0 | 155 | N-liked | Kaushansky, K., Lopez, J., and Brown, C. (1992)Biochemistry, 31, 1881-1886. Medline: 92144609; | OGlycBase6.0 | 169 | N-liked | Kaushansky, K., Lopez, J., and Brown, C. (1992)Biochemistry, 31, 1881-1886. Medline: 92144609; | OGlycBase6.0 | 214 | N-liked | Kaushansky, K., Lopez, J., and Brown, C. (1992)Biochemistry, 31, 1881-1886. Medline: 92144609; | OGlycBase6.0 |
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Methylation Profile [Top] | ||
There is no record for CSF2 | ||