| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1490 |
Name | CTGF |
Synonymous | CCN2|HCS24|IGFBP8|NOV2;connective tissue growth factor;CTGF;connective tissue growth factor |
Definition | CCN family member 2|IBP-8|IGF-binding protein 8|IGFBP-8|hypertrophic chondrocyte-specific protein 24|insulin-like growth factor-binding protein 8 |
Position | 6q23.1 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
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Regulation From TransFac database |
CTGF(h) --> MEK(h){pS217}{pS221} (increase of phosphorylation) | CTGF(h) --> JNK(h){pT183}{pY185} (increase of phosphorylation) | CTGF(h) --> RSK(h){pS} (increase of phosphorylation) | CTGF(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | CTGF(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | CTGF(h) --> MKK4(h){pT261} (increase of phosphorylation) | CTGF(h) --> ATF-2(h){pT} (increase of phosphorylation) | CTGF(h) --> CaMKII-alpha(h){pT286} (increase of phosphorylation) | CTGF(h) --> AKT-1(h){pT308}{pS473} (increase of phosphorylation) | trkA(h) + CTGF(h) <==> trkA(h):CTGF(h) (binding) | p75NTR(h) + CTGF(h) <==> p75NTR(h):CTGF(h) (binding) | CTGF(h) --> CTGF(h) (expression). | CTGF(h) --> CTGF-isoform1(h) (expression). | CTGF(h) --> CTGF-isoform2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
28 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 225 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr6 |
Promoter: 132313711 - 132315711 | Agilent_014791 |
chr6 |
Promoter: 132313711 - 132315711 | GoldenGate_Methylation_Cancer_Panel_I |
chr6 |
Promoter: 132313711 - 132315711 | GSE27584 |
chr6 |
Promoter: 132313711 - 132315711 | Agilent_014791_44K |
chr6 |
Promoter: 132313711 - 132315711 | PMID:15911243 |