| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 1601 |
Name | DAB2 |
Synonymous | DOC-2|DOC2;Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila);DAB2;Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
Definition | adaptor molecule disabled-2|differentially expressed in ovarian carcinoma 2|differentially-expressed protein 2|disabled homolog 2|disabled homolog 2, mitogen-responsive phosphoprotein |
Position | 5p13.1 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
Dab2(h) --> Dab2(h) (expression). | Dab2(h) --> c-Jun(m.s.){pS63} (binding) | Dab2(h) --> fibronectin(h) (increase of abundance) | Dab2(h) --> Smad2(h){p} (increase of phosphorylation) | Smad2(m.s.) + Dab2(h) <==> Smad2(m.s.):Dab2(h) (binding) | Dab2(h) + Smad3(m.s.) <==> Dab2(h):Smad3(m.s.) (binding) | Smad2(h) + Dab2(h) <==> Smad2(h):Dab2(h) (binding) | Dab2(h) + Smad3(h) <==> Dab2(h):Smad3(h) (binding) | TGFbetaR-I(h) + Dab2(h) <==> TGFbetaR-I(h):Dab2(h) (binding) | TGFbetaR-II(h) + Dab2(h) <==> TGFbetaR-II(h):Dab2(h) (binding) | Dab2(h) --> Dab2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
221 | Phosphothreonine. | Swiss-Prot 53.0 | 227 | Phosphoserine. | Swiss-Prot 53.0 | 342 | Phosphotyrosine. | Swiss-Prot 53.0 | 393 | Phosphoserine. | Swiss-Prot 53.0 | 394 | Phosphoserine. | Swiss-Prot 53.0 | 401 | Phosphoserine. | Swiss-Prot 53.0 | 24 | Phosphoserine (PKC alpha;PK) | 10542228;11812785 | Phospho.ELM 6.0 | 401 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 227 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 221 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr5 |
Promoter: 39460203 - 39462203 | Agilent_014791 |
chr5 |
Promoter: 39460203 - 39462203 | GoldenGate_Methylation_Cancer_Panel_I |
chr5 |
Promoter: 39460203 - 39462203 | GSE27584 |
chr5 |
Promoter: 39460203 - 39462203 | Agilent_014791_44K |
chr5 |
Promoter: 39460203 - 39462203 | Agilent_014791 |
chr5 |
Promoter: 39460203 - 39462203 | PMID:17115114 |
chr5 |
Promoter: 39460203 - 39462203 | PMID:15041729 |