Entrez Gene

Basic Information
Gene ID	1676
Name	DFFA
Synonymous	DFF-45\|DFF1\|ICAD;DNA fragmentation factor, 45kDa, alpha polypeptide;DFFA;DNA fragmentation factor, 45kDa, alpha polypeptide
Definition	DFF45\|DNA fragmentation factor 45 kDa subunit\|DNA fragmentation factor subunit alpha\|inhibitor of CAD
Position	1p36.3-p36.2
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
ICAD(h) --Caspase-3(ha)--> protein remnants (processing)
ICAD(h) --Caspase-3(h)--> protein remnants (processing)
ICAD(h) --> ICAD-p25(h) + protein remnants (cleavage)
ICAD(h) --> ICAD-p17(h) + protein remnants (cleavage)
ICAD(h) --> ICAD-p11(h) + protein remnants (cleavage)
ICAD(h) --Caspase-9(h)--> protein remnants (cleavage)
14-3-3zeta(h) + ICAD(h) <==> 14-3-3zeta(h):ICAD(h) (binding)
ICAD(h) + CAD(h) <==> CAD(h):ICAD(h) (binding)
ICAD(h) + P532(h) <==> ICAD(h):P532(h) (binding)
ICAD(h) + MCC1(h) <==> ICAD(h):MCC1(h) (binding)
ICAD(h) + DRLM(h) <==> ICAD(h):DRLM(h) (binding)
ZPRO(h) + ICAD(h) <==> ZPRO(h):ICAD(h) (binding)
Bak(h) + ICAD(h) <==> Bak(h):ICAD(h) (binding)
ICAD(h) + Unph4(h) <==> ICAD(h):Unph4(h) (binding)
ICAD(h) + EWS(h) <==> ICAD(h):EWS(h) (binding)
ICAD(h) + EFCBP2(h) <==> ICAD(h):EFCBP2(h) (binding)
DFFA(h) --> ICAD(h) (expression).
Apo2L(h) --> ICAD(h) (increase of cleavage)
Bcl-2(m.s.) --> ICAD(h) (decrease of cleavage)
Bcl-2(h) --> ICAD(h) (decrease of cleavage)
Cdk5(h) --> ICAD(h) (decrease of cleavage)
DFFA(h) --> DFF45(h) (expression).
DFFA(h) --> DFF35(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
315	Phosphoserine.		Swiss-Prot 53.0