| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1786 |
Name | DNMT1 |
Synonymous | ADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT;DNA (cytosine-5-)-methyltransferase 1;DNMT1;DNA (cytosine-5-)-methyltransferase 1 |
Definition | CXXC-type zinc finger protein 9|DNA (cytosine-5)-methyltransferase 1|DNA MTase HsaI|DNA methyltransferase HsaI|m.HsaI |
Position | 19p13.2 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
|
Regulation From TransFac database |
Dnmt1(h) + Sp1(h) <==> Sp1(h):Dnmt1(h) (binding) | PCNA(h) + Dnmt1(h) <==> PCNA(h):Dnmt1(h) (binding) | Dnmt1(h) --> protein remnants (degradation) | Daxx(h) + Dnmt1(h) <==> Daxx(h):Dnmt1(h) (binding) | DMAP1(m.s.) + Dnmt1(h) <==> DMAP1(m.s.):Dnmt1(h) (binding) | Dnmt1(h) + DNA (cytosine-5)-methyltransferase 3B(h) <==> Dnmt1(h):DNA (cytosine-5)-methyltransferase 3B(h) (binding) | HDAC1(h) + E2F-1(h) + pRb(h) + Dnmt1(h) <==> HDAC1(h):E2F-1(h):pRb(h):Dnmt1(h) (binding) | pRb(h) + Dnmt1(h) <==> pRb(h):Dnmt1(h) (binding) | MATH1(m.s.) + Dnmt1(h) <==> MATH1(m.s.):Dnmt1(h) (binding) | DNMT1(h) --> Dnmt1(h) (expression). | PCNA(h) + Dnmt1-1(h) <==> PCNA(h):Dnmt1-1(h) (binding) | pRb(m.s.) + Dnmt1-1(h) <==> pRb(m.s.):Dnmt1-1(h) (binding) | Dnmt1-1(h) --/ CDKN2A(h) (transrepression) | DNMT1(h) --> Dnmt1-1(h) (expression). | DNMT1(h) --> Dnmt1-2(h) (expression). | DNMT1(h) --> Dnmt1-3(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
127 | Phosphoserine. | Swiss-Prot 53.0 | 509 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 714 | Phosphoserine. | Swiss-Prot 53.0 | 954 | Phosphoserine. | Swiss-Prot 53.0 | 1105 | Phosphoserine. | Swiss-Prot 53.0 | 1113 | N6-acetyllysine. | Swiss-Prot 53.0 | 1115 | N6-acetyllysine. | Swiss-Prot 53.0 | 1117 | N6-acetyllysine. | Swiss-Prot 53.0 | 714 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 | 954 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 127 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1105 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr19 |
Promoter: 10166311 - 10168311 | Agilent_014791 |
chr19 |
Promoter: 10166311 - 10168311 | GoldenGate_Methylation_Cancer_Panel_I |
chr19 |
Promoter: 10166311 - 10168311 | GSE27584 |
chr19 |
Promoter: 10166311 - 10168311 | Agilent_014791_44K |