Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

2146

Name

EZH2

Synonymous

ENX-1|ENX1|EZH1|EZH2b|KMT6|KMT6A|WVS|WVS2;enhancer of zeste 2 polycomb repressive complex 2 subunit;EZH2;enhancer of zeste 2 polycomb repressive complex 2 subunit

Definition

enhancer of zeste homolog 2|histone-lysine N-methyltransferase EZH2|lysine N-methyltransferase 6

Position

7q35-q36

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

hdac2(h) + EZH2(h) <==> hdac2(h):EZH2(h) (binding)
EZH2(h) + HDAC1(h) <==> EZH2(h):HDAC1(h) (binding)
EZH2(h) + EED(h) <==> EED(h):EZH2(h) (binding)
EED(h) + EZH2(h) + HDAC1(h) + hdac2(h) <==> EED(h):EZH2(h):HDAC1(h):hdac2(h) (binding)
EZH2(h) + DIPA(h) <==> EZH2(h):DIPA(h) (binding)
EZH2(h) + POLA2(h) <==> EZH2(h):POLA2(h) (binding)
EZH2(h) --> EZH2(h) (expression).
EZH2(h) --> EZH2(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

487Phosphothreonine.Swiss-Prot 53.0
487Phosphothreonine15302935;17081983Phospho.ELM 6.0
21Phosphoserine16224021Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr7

Promoter: 148211847 - 148213847Agilent_014791

chr7

Promoter: 148211847 - 148213847GSE27584

chr7

Promoter: 148211847 - 148213847GSE27584

chr7

Promoter: 148211847 - 148213847Agilent_014791_44K


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