Entrez Gene

Basic Information
Gene ID	2521
Name	FUS
Synonymous	ALS6\|ETM4\|FUS1\|HNRNPP2\|POMP75\|TLS;FUS RNA binding protein;FUS;FUS RNA binding protein
Definition	75 kDa DNA-pairing protein\|RNA-binding protein FUS\|fus-like protein\|fused in sarcoma\|fusion gene in myxoid liposarcoma\|heterogeneous nuclear ribonucleoprotein P2\|oncogene FUS\|oncogene TLS\|translocated in liposarcoma protein
Position	16p11.2
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
ILF3(h) + TLS(h) <==> ILF3(h):TLS(h) (binding)
TLS(h) + RXR-alpha(m) <==> TLS(h):RXR-alpha(m) (binding)
TLS(h) + ER-alpha-L(h) <==> TLS(h):ER-alpha-L(h) (binding)
T3R-alpha(c) + TLS(h) <==> T3R-alpha(c):TLS(h) (binding)
TLS(h) --> PPAT(h) (DNA binding).
TLS(h) --> PAICS(h) (DNA binding).
CAB(h) + TLS(h) <==> CAB(h):TLS(h) (binding)
USF2(h) + TLS(h) <==> USF2(h):TLS(h) (binding)
TLS(h) + PTB1(h) <==> TLS(h):PTB1(h) (binding)
SRp75(h) + PR264(h) + TLS(h) <==> SRp75(h):PR264(h):TLS(h) (binding)
SRm160(h) + TLS(h) <==> SRm160(h):TLS(h) (binding)
ddx1(h) + DDX3(h) + p72(h) + p68(h) + DDX15(h) + NF45(h) + HNRPH1(h) + EWS(h) + TDP43(h) + RN3(m.s.) + HNRPUL1(h) + raly(h) + SRPK1(h) + taf15(h) + TLS(h) + JKTBP(h) + hnRNPM(h) + SAF-A(h) + DRBP76(h) + Gy1(h) <==> ddx1(h):DDX3(h):p72(h):p68(h):DDX15(h):NF45(h):HNRPH1(h):EWS(h):TDP43(h):RN3(m.s.):HNRPUL1(h):raly(h):SRPK1(h):taf15(h):TLS(h):JKTBP(h):hnRNPM(h):SAF-A(h):DRBP76(h):Gy1(h) (binding)
FUS(h) --> TLS(h) (expression).
FUS-L(h) + T3R-alpha(c) <==> FUS-L(h):T3R-alpha(c) (binding)
FUS-L(h) + GR(r) <==> FUS-L(h):GR(r) (binding)
FUS-L(h) + PU.1-xbb1(m) <==> FUS-L(h):PU.1-xbb1(m) (binding)
FUS(h) --> FUS-L(h) (expression).
FUS(h) --> FUS-S(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
216	Omega-N-methylated arginine.		Swiss-Prot 53.0
218	Omega-N-methylated arginine.		Swiss-Prot 53.0
257	Phosphoserine (PKC beta)	10913197	Phospho.ELM 6.0