Entrez Gene

Basic Information
Gene ID	317
Name	APAF1
Synonymous	APAF-1\|CED4;apoptotic peptidase activating factor 1;APAF1;apoptotic peptidase activating factor 1
Definition	apoptotic protease-activating factor 1
Position	12q23
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Experimentally validated miRNA-TS gene regulation information.

Regulation From TransFac database
Transcription Factors [Top]
Cytochrome C(h) + Apaf-1(h) + Caspase-9(h) + dATP <==> Cytochrome C(h):Apaf-1(h):Caspase-9(h):dATP (binding)
Bcl-X(h) + Apaf-1(h) <==> Bcl-X(h):Apaf-1(h) (binding)
Apaf-1(h) + Caspase-4(h) <==> Apaf-1(h):Caspase-4(h) (binding)
Apaf-1(h) + CED-3(ce) <==> Apaf-1(h):CED-3(ce) (binding)
Apaf-1(h) + proCaspase-9(h) <==> Apaf-1(h):proCaspase-9(h) (binding)
Apaf-1(h) + proCaspase-8(h) <==> Apaf-1(h):proCaspase-8(h) (binding)
Boo(m) + Apaf-1(h) <==> Boo(m):Apaf-1(h) (binding)
Aven(h) + Apaf-1(h) <==> Aven(h):Apaf-1(h) (binding)
Apaf-1(h) + ATP <==> Apaf-1(h):ATP (binding)
2 Apaf-1(h) <==> Apaf-1(h):Apaf-1(h) (oligomerization)
Hsp70-1(h) + Apaf-1(h) <==> Hsp70-1(h):Apaf-1(h) (binding)
Hsp90(h) + Apaf-1(h) <==> Hsp90(h):Apaf-1(h) (binding)
NAC-beta(h) + Apaf-1(h) <==> NAC-beta(h):Apaf-1(h) (binding)
Apaf-1(h) --Caspase-8(h)--> Apaf-1-p84(h) + protein remnants (processing)
Apaf-1(h) + proCaspase-9(h) + proCaspase-3(h) <==> Apaf-1(h):proCaspase-9(h):proCaspase-3(h) (binding)
Apaf-1(h) --Caspase-3(h)--> Apaf-1-p84(h) + protein remnants (processing)
proCaspase-3(h) + XIAP(h) + Cytochrome C(h) + Apaf-1(h) + proCaspase-9(h) <==> proCaspase-3(h):XIAP(h):Cytochrome C(h):Apaf-1(h):proCaspase-9(h) (binding)
Cytochrome C(h) + Apaf-1(h) <==> Cytochrome C(h):Apaf-1(h) (binding)
Apaf-1(h) + Hsp70(h) <==> Apaf-1(h):Hsp70(h) (binding)
proCaspase-2(h) + proCaspase-9(h) + Apaf-1(h) + proCaspase-3(h) <==> proCaspase-2(h):proCaspase-9(h):Apaf-1(h):proCaspase-3(h) (binding)
Apaf-1(h) + Caspase-9-p35(h) <==> Apaf-1(h):Caspase-9-p35(h) (binding)
Caspase-9-p35(h) + Apaf-1(h) + XIAP(h) <==> Caspase-9-p35(h):Apaf-1(h):XIAP(h) (binding)
HSPC132(m.s.) + Apaf-1(h) <==> HSPC132(m.s.):Apaf-1(h) (binding)
Apaf-1(h) + HSPC132(h) <==> Apaf-1(h):HSPC132(h) (binding)
APAF1(h) --> Apaf-1(h) (expression).
proCaspase-9(h) --Apaf-1(h)--> Caspase-9(h) (processing)
Hsp70-1(h) + Apaf-1L(h) <==> Hsp70-1(h):Apaf-1L(h) (binding)
Cytochrome C(m.s.) + 8 Apaf-1L(h) <==> Cytochrome C(m.s.):(Apaf-1L(h))8 (binding)
8 Apaf-1L(h) + proCaspase-9(m.s.) <==> (Apaf-1L(h))8:proCaspase-9(m.s.) (binding)
2 Apaf-1L(h) <==> (Apaf-1L(h))2 (binding)
Cytochrome C(m.s.) + Apaf-1L(h) <==> Cytochrome C(m.s.):Apaf-1L(h) (binding)
APAF1(h) --> Apaf-1L(h) (expression).
APAF1(h) --> Apaf-1S(h) (expression).
APAF1(h) --> Apaf-1XL(h) (expression).
APAF1(h) --> Apaf-1M(h) (expression).
APAF1(h) --> Apaf-1XS(h) (expression).
APAF1(h) --> Apaf-1ALT(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
204	Phosphothreonine.		Swiss-Prot 53.0
238	Phosphoserine.		Swiss-Prot 53.0
248	Phosphoserine.		Swiss-Prot 53.0
204	Phosphothreonine	17081983	Phospho.ELM 6.0
238	Phosphoserine	17081983	Phospho.ELM 6.0
248	Phosphoserine	17081983	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr12	Promoter: 97561709 - 97563709	GSE27584
chr12	Promoter: 97561709 - 97563709	GSE27584
chr12	Promoter: 97561709 - 97563709	GSE27584
chr12	Promoter: 97561709 - 97563709	GSE27584
chr12	Promoter: 97561709 - 97563709	GSE27584
chr12	Promoter: 97561709 - 97563709	Agilent_014791_44K
chr12	Promoter: 97561709 - 97563709	Agilent_014791
chr12	Promoter: 97561709 - 97563709	PMID:15198948
chr12	Promoter: 97561709 - 97563709	PMID:15198948
chr12	Promoter: 97561709 - 97563709	PMID:15198948
chr12	Promoter: 97561709 - 97563709	PMID:15198948
chr12	Promoter: 97561709 - 97563709	PMID:15198948
chr12	Promoter: 97561709 - 97563709	PMID:16192589
chr12	Promoter: 97561709 - 97563709	PMID:16192589
chr12	Promoter: 97561709 - 97563709	PMID:16192589
chr12	Promoter: 97561709 - 97563709	PMID:16192589
chr12	Promoter: 97561709 - 97563709	PMID:16192589
chr12	Promoter: 97561709 - 97563709	PMID:15972851
chr12	Promoter: 97561709 - 97563709	PMID:15972851
chr12	Promoter: 97561709 - 97563709	PMID:15972851
chr12	Promoter: 97561709 - 97563709	PMID:15972851
chr12	Promoter: 97561709 - 97563709	PMID:15972851
chr12	Promoter: 97561709 - 97563709	PMID:16697107
chr12	Promoter: 97561709 - 97563709	PMID:16697107
chr12	Promoter: 97561709 - 97563709	PMID:16697107
chr12	Promoter: 97561709 - 97563709	PMID:16697107
chr12	Promoter: 97561709 - 97563709	PMID:16697107
chr12	Promoter: 97561709 - 97563709	PMID:17133271
chr12	Promoter: 97561709 - 97563709	PMID:17133271
chr12	Promoter: 97561709 - 97563709	PMID:17133271
chr12	Promoter: 97561709 - 97563709	PMID:17133271
chr12	Promoter: 97561709 - 97563709	PMID:17133271
chr12	Promoter: 97561709 - 97563709	PMID:16642478
chr12	Promoter: 97561709 - 97563709	PMID:16642478
chr12	Promoter: 97561709 - 97563709	PMID:16642478
chr12	Promoter: 97561709 - 97563709	PMID:16642478
chr12	Promoter: 97561709 - 97563709	PMID:16642478
chr12	Promoter: 97561709 - 97563709	PMID:16951219
chr12	Promoter: 97561709 - 97563709	PMID:16951219
chr12	Promoter: 97561709 - 97563709	PMID:16951219
chr12	Promoter: 97561709 - 97563709	PMID:16951219
chr12	Promoter: 97561709 - 97563709	PMID:16951219

Experimentally verified miRNA from miRTarBase [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]