| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 355 |
Name | FAS |
Synonymous | ALPS1A|APO-1|APT1|CD95|FAS1|FASTM|TNFRSF6;Fas cell surface death receptor;FAS;Fas cell surface death receptor |
Definition | APO-1 cell surface antigen|CD95 antigen|Delta Fas/APO-1/CD95|FAS 827dupA|FAS receptor variant 9|FASLG receptor|Fas (TNF receptor superfamily, member 6)|Fas AMA|TNF receptor superfamily member 6|apoptosis antigen 1|apoptosis-mediating surface antigen FAS|t |
Position | 10q24.1 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
Fas(h) + FADD(h) <==> Fas(h):FADD(h) (binding) | Fas(h) + RIP(h) <==> Fas(h):RIP(h) (binding) | FasL(h) + Fas(h) <==> FasL(h):Fas(h) (binding) | Fas(h) + FAP-1(h) <==> Fas(h):FAP-1(h) (binding) | Fas(h) + FAP-1(m) <==> Fas(h):FAP-1(m) (binding) | c-Met(h) + Fas(h) <==> c-Met(h):Fas(h) (binding) | Fas(h) + sumo1(h) <==> Fas(h):sumo1(h) (binding) | c-FLIP-L-p43(h) + FADD(h) + Fas(h) + FasL(h) + proCaspase-8(h) <==> FasL(h):Fas(h):FADD(h):proCaspase-8(h):c-FLIP-L-p43(h) (binding) | Fas(h) + ASK1(h) <==> Fas(h):ASK1(h) (binding) | Fas(h) + Daxx(h) + ASK1(h) <==> Fas(h):Daxx(h):ASK1(h) (binding) | Fas(h) + FAF1(h) <==> Fas(h):FAF1(h) (binding) | proCaspase-8(h) + Fas(h) <==> Fas(h):proCaspase-8(h) (binding) | FADD(h) + FasL(h) + Fas(h) + proCaspase-10(h) <==> FADD(h):FasL(h):Fas(h):proCaspase-10(h) (binding) | proCaspase-10(h) + FADD(h) + Fas(h) <==> proCaspase-10(h):FADD(h):Fas(h) (binding) | FADD(h) + FasL(h) + Fas(h) <==> FADD(h):FasL(h):Fas(h) (binding) | Fas(h) + c-FLIP-L-p43(h) + Caspase-8a-p43(h) <==> Caspase-8a-p43(h):c-FLIP-L-p43(h):Fas(h) (binding) | Fas(h) + c-FLIP-L-p43(h) + Caspase-8b-p41(h) <==> c-FLIP-L-p43(h):Caspase-8b-p41(h):Fas(h) (binding) | FADD(h) + Fas(h) + c-FLIP-L-p43(h) <==> c-FLIP-L-p43(h):Fas(h):FADD(h) (binding) | Fas(h) + c-FLIP-L(h) <==> Fas(h):c-FLIP-L(h) (binding) | Fas(h) + Daxx(h) <==> Fas(h):Daxx(h) (binding) | Fas(h) --> c-FLIP(m) (binding) | Fas(h) --> TRAF1(h) (binding) | Fas(h) --> TRAF2(h) (binding) | Fas(h) --> Raf-1(h) (binding) | Fas(h) + Btk(h) <==> Fas(h):Btk(h) (binding) | c-FLIP-L-p43(h) + FADD(h) + Fas(h) + proCaspase-10(h) <==> c-FLIP-L-p43(h):FADD(h):Fas(h):proCaspase-10(h) (binding) | Fas(h) + FADD(m.s.) <==> Fas(h):FADD(m.s.) (binding) | Fas(h) --> proCaspase-8(h) (increase of processing) | Fas(h) --> proCaspase-3(h) (increase of processing) | c-FLIP-L-p43(h) + FADD(h) + Fas(h) + proCaspase-8(h) <==> c-FLIP-L-p43(h):FADD(h):Fas(h):proCaspase-8(h) (binding) | Fas(h) --> Bid(h) (increase of processing) | c-FLIP-L-p43(h) + FADD(h) + proCaspase-8(h) + Fas(h) <==> c-FLIP-L-p43(h):Fas(h):FADD(h):proCaspase-8(h) (binding) | Fas(h) + FasL(h) + c-FLIP-S(m.s.) + FADD(h) + proCaspase-8(h) + c-FLIP-L-p43(h) <==> Fas(h):FasL(h):c-FLIP-S(m.s.):FADD(h):proCaspase-8(h):c-FLIP-L-p43(h) (binding) | Fas(h) + FasL(h) + FADD(h) + Caspase-8-p43(h) + c-FLIP-L-p43(m.s.) <==> Fas(h):FasL(h):FADD(h):Caspase-8-p43(h):c-FLIP-L-p43(m.s.) (binding) | Fas(h) + Caspase-8-p43(h) + FADD(h) + RIP(h) + c-FLIP-L-p43(h) + c-FLIP-S(h) <==> Fas(h):Caspase-8-p43(h):FADD(h):RIP(h):c-FLIP-L-p43(h):c-FLIP-S(h) (binding) | Fas(h) + FADD(h) + proCaspase-8(h) + c-FLIP-p22(m.s.) <==> Fas(h):FADD(h):proCaspase-8(h):c-FLIP-p22(m.s.) (binding) | Fas(h) + FADD(h) + c-FLIP-L-p43(h) + Caspase-8-p18(h) <==> Fas(h):FADD(h):c-FLIP-L-p43(h):Caspase-8-p18(h) (binding) | Fas(h) + FADD(h) + c-FLIP-R(h) + c-FLIP-L-p43(h) + Caspase-8-p18(h) <==> Fas(h):FADD(h):c-FLIP-R(h):c-FLIP-L-p43(h):Caspase-8-p18(h) (binding) | Fas(h) + FADD(h) + c-FLIP-S(h) + c-FLIP-L-p43(h) + Caspase-8-p43(h) <==> Fas(h):FADD(h):c-FLIP-S(h):c-FLIP-L-p43(h):Caspase-8-p43(h) (binding) | Fas(h) + proCaspase-2(h) + Caspase-8-p43(h) <==> Fas(h):proCaspase-2(h):Caspase-8-p43(h) (binding) | Fas(h) + FADD(h) + Caspase-8-p18(h) + Caspase-2-p33(h) <==> Fas(h):FADD(h):Caspase-8-p18(h):Caspase-2-p33(h) (binding) | Fas(h) + FADD(h) + proCaspase-2(h) + Caspase-8-p43(h) <==> Fas(h):FADD(h):proCaspase-2(h):Caspase-8-p43(h) (binding) | Fas(h) + proCaspase-8(h) + Caspase-2-p33(h) <==> Fas(h):proCaspase-8(h):Caspase-2-p33(h) (binding) | Fas(h) + proCaspase-2(h) + proCaspase-8(h) <==> Fas(h):proCaspase-2(h):proCaspase-8(h) (binding) | Fas(h) + FADD(h) + proCaspase-8(h) <==> Fas(h):FADD(h):proCaspase-8(h) (binding) | Fas(h) + proCaspase-8(h) + FADD(h) <==> Fas(h):proCaspase-8(h):FADD(h) (binding) | Fas(h) + FADD(h) <==> Fas(h):FADD(h) (binding) | Fas(h) + p75NTR(h) <==> Fas(h):p75NTR(h) (binding) | Caspase-8-p43(h) + FasL(h) + FADD(h) + Fas(h) <==> Caspase-8-p43(h):FasL(h):FADD(h):Fas(h) (binding) | n Fas(h) <==> (Fas(h))n (oligomerization; binding) | c-FLIP-R(h) + c-FLIP-L(h) + proCaspase-8a(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L(h):proCaspase-8a(h):FADD(h):Fas(h) (binding) | c-FLIP-R(h) + c-FLIP-L(h) + proCaspase-8b(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L(h):proCaspase-8b(h):FADD(h):Fas(h) (binding) | c-FLIP-R(h) + c-FLIP-L-p43(h) + Caspase-8a-p43(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L-p43(h):Caspase-8a-p43(h):FADD(h):Fas(h) (binding) | c-FLIP-R(h) + c-FLIP-L-p43(h) + Caspase-8b-p41(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L-p43(h):Caspase-8b-p41(h):FADD(h):Fas(h) (binding) | c-FLIP-L(h) + proCaspase-8a(h) + Fas(h) <==> c-FLIP-L(h):proCaspase-8a(h):Fas(h) (binding) | c-FLIP-L(h) + proCaspase-8b(h) + Fas(h) <==> c-FLIP-L(h):proCaspase-8b(h):Fas(h) (binding) | c-FLIP-L-p43(h) + Caspase-8a-p43(h) + Fas(h) <==> c-FLIP-L-p43(h):Caspase-8a-p43(h):Fas(h) (binding) | Fas(h) + CRMP1(h) <==> Fas(h):CRMP1(h) (binding) | Fas(h) + EEF1A(h) <==> Fas(h):EEF1A(h) (binding) | FAS(h) --> Fas(h) (expression). | TNFR1(h) --> Fas(h) (binding) | Btk(h) --/ Fas(h) (inhibition) | amylin(h) --> Fas(h) (increase of abundance) | Apak(h) --/ Fas(h) (decrease of abundance) | FAS(h) --> Fas-isoform-1(h) (expression). | FAS(h) --> Fas-isoform-2(h) (expression). | FAS(h) --> Fas-isoform-3(h) (expression). | FAS(h) --> Fas-isoform-4(h) (expression). | FAS(h) --> Fas-isoform-5(h) (expression). | FAS(h) --> Fas-isoform-6(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
118 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 136 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr10 |
Promoter: 90738768 - 90740768 | Agilent_014791 |
chr10 |
Promoter: 90738768 - 90740768 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 90738768 - 90740768 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 90738768 - 90740768 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 90738768 - 90740768 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 90738768 - 90740768 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 90738768 - 90740768 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 90738768 - 90740768 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 90738768 - 90740768 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 90738768 - 90740768 | GSE27584 |
chr10 |
Promoter: 90738768 - 90740768 | GSE27584 |
chr10 |
Promoter: 90738768 - 90740768 | GSE27584 |
chr10 |
Promoter: 90738768 - 90740768 | Agilent_014791_44K |
chr10 |
Promoter: 90738768 - 90740768 | Agilent_014791_44K |
chr10 |
Promoter: 90738768 - 90740768 | Agilent_014791_44K |
chr10 |
Promoter: 90738768 - 90740768 | Agilent_014791 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:20064646 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:20064646 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:20064646 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:20064646 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:20064646 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:20064646 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:20064646 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:20064646 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:12700649 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:12700649 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:12700649 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:12700649 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:12700649 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:12700649 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:12700649 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:12700649 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:11568974 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:11568974 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:11568974 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:11568974 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:11568974 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:11568974 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:11568974 |
chr10 |
Promoter: 90738768 - 90740768 | PMID:11568974 |