| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 3605 |
Name | IL17A |
Synonymous | CTLA8|IL-17|IL-17A|IL17;interleukin 17A;IL17A;interleukin 17A |
Definition | CTLA-8|cytotoxic T-lymphocyte-associated antigen 8|cytotoxic T-lymphocyte-associated protein 8|interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)|interleukin-17A |
Position | 6p12 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
IL-17A(h) --> Jak1(h) (activation; phosphorylation) | IL-17A(h) --> Jak2(h) (activation; phosphorylation) | IL-17A(h) --> Jak3(h) (activation; phosphorylation) | IL-17A(h) --> Tyk2(h) (activation; phosphorylation) | IL-17A(h) --> STAT1(h) (activation; phosphorylation) | IL-17A(h) --> STAT2(h) (activation; phosphorylation) | IL-17A(h) --> STAT3(h) (activation; phosphorylation) | IL-17A(h) --> STAT4(h) (activation; phosphorylation) | IL-17A(h) --> IL-1beta(h) (activation) | IL-17A(h) --> TNF-alpha(h) (activation) | IL-17A(h) --> IL-6(h) (activation) | IL-17A(h) --> IL-10(h) (activation) | IL-17A(h) --> IL-1RA(h) (activation) | IL-17A(h) --> IL-12(h) (activation) | IL-17A(h) --> PGE2 (activation) | IL-17A(h) --> stromelysin1(h) (activation) | IL-17A(h) --> Ca (activation) | 2 IL-17A(h) <==> (IL-17A(h))2 (binding) | IL-17F(h) + IL-17A(h) <==> IL-17F(h):IL-17A(h) (binding) | IL17A(h) --> IL-17A(h) (expression). | IL-17A(h) --> MMP1(h) (transactivation) | IL-17A(h) --> mmp1(h) (increase of abundance) | IL-17A(h) --> RelA-p65(h) (increase of abundance) | IL-17A(h) --> NF-kappaB1(h) (increase of abundance) | IL-17A(h) --> c-Fos(h) (increase of abundance) | IL-17A(h) --> FOSB(h) (increase of abundance) | IL-17A(h) --> c-Jun(h) (increase of abundance) | IL-17A(h) --> Fra-1(h) (increase of abundance) | IL-17A(h) --> JunD(h) (increase of abundance) | IL-17A(h) --> C/EBPbeta(h) (increase of abundance) | IL-17A(h) --> p38(h){p} (increase of abundance) | IL-17A(h) --> ATF-2(h){pT71} (increase of phosphorylation) | IL-17A(h) --> ERK1(h){p} (increase of phosphorylation) | IL-17A(h) --> ERK2(h){p} (increase of phosphorylation) | IL-17A(h) --> ELK(h){pS} (increase of phosphorylation) | IL-17A(h) --> mmp2(h) (increase of abundance) | IL-17A(h) --> stromelysin1(h) (increase of abundance) | IL-17A(h) --> gelatinase B(h) (increase of abundance) | IL-17A(h) --> MMP-13(h) (increase of abundance) | IL-17A(h) --> TIMP-1(h) (increase of abundance) | IL-17A(h) + IL-17RC(h) <==> IL-17A(h):IL-17RC(h) (binding) | IL-17A(h) + IL-17RA(h) <==> IL-17A(h):IL-17RA(h) (binding) | IL-17A(h) --> IL-8(h) (increase of secretion) | IL-17A(h) --> IL-6(h) (increase of secretion) | IL-17A(h) --> GROalpha(h) (increase of secretion) | IL-17A(h) + IL-17RC(m) <==> IL-17A(h):IL-17RC(m) (binding) | IL-17A(h) --> G-CSF(h) (increase of secretion) | IL-17A(h) --> MCP-1(h) (increase of secretion) | IL-17A(h) --> IkappaB-alpha(m){p} (increase of phosphorylation) | 2 IL-17A(h) <==> (IL-17A(h))2 (binding; oligomerization) | IL-17A(h) --> DEFB4(h) (transactivation) | IL-17A(h) + NDP-Gly --> IL-17A(h){gly} + NMP (glycosylation) | IL-17A(h) --> prostaglandin E synthase 2(h) (increase of secretion) | IL-17A(h) --> IL19(h) (transactivation) | IL-17A(h) --> CXCL1(h) (transactivation) | IL-17A(h) --> CXCL2(h) (transactivation) | IL-17A(h) --> GRO3(h) (transactivation) | IL-17A(h) --> CXCL5(h) (transactivation) | IL-17A(h) --> CXCL6(h) (transactivation) | IL-17A(h) --> PIP3 (increase of secretion) | IL-17A(h) --> AKT-1(h){pT308}{pS473} (increase of phosphorylation) | IL-17A(h) --> GROalpha(m) (increase of secretion) | IL-17A(h) + IL-17F(h) <==> IL-17A(h):IL-17F(h) (binding) | IL-17A(h) --> GSK3beta(h){pS9} (increase of phosphorylation) | IL-17A(h) --> IL1B(h) (transactivation) | IL-17A(h) --> NOS2(h) (transactivation) | IL-17A(h) --> Jak2(h){pY1007}{pY1008} (increase of phosphorylation) | IL-17A(h) --> Jak1(h){pY} (increase of phosphorylation) | IL-17A(h) --> PTGS2(h) (transactivation) | IL-17A(h) --> IL6(h) (transactivation) | IL-17A(h) --> iNOS(h) (increase of abundance) | IL-17A(h) --> STAT3(h){pY705} (increase of phosphorylation) | IL-17A(h) --> CRP(h) (transactivation) | IL-17A(h) --> IL8(h) (transactivation) | IL-17A(h) --> Muc5AC(h) (increase of secretion) | IL-17A(h) --> Cxcl1(m) (transactivation) | IL-17A(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | IL-17A(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | IL-17A(h) --> COX2(h) (increase of abundance) | IL-17A(h) --> p38(b){p} (increase of phosphorylation) | IL-17A(h) --> ERK1(b){p} (increase of phosphorylation) | IL-17A(h) --> ERK2(b){p} (increase of phosphorylation) | IL-17A(h) --> JNK1(h){p} (increase of phosphorylation) | IL-17A(h) --/ IkappaB-alpha(b) (decrease of abundance) | IL-17A(h) --> S100A7(h) (transactivation) | IL-17A(h) --> S100A8(h) (transactivation) | IL-17A(h) --> S100A9(h) (transactivation) | IL-17A(h) --/ IkappaB-alpha(h) (decrease of abundance) | IL-17A(h) --> NFKBIZ(h) (transactivation) | IL-17A(h) --> CRP(h) (increase of secretion) | IL-17A(h) --> c-Rel(h) (increase of abundance) | IL-17A(h) --> C/EBPalpha(h) (increase of abundance) | IL-17A(h) --> C/EBPbeta(h){pT235} (increase of phosphorylation) | IL-17A(h) --> p38alpha(h){pT180}{pY182} (increase of phosphorylation) | IL-17A(h) --> Nfkbiz(m) (transactivation) | IL-17A(h) --> Fas(m) (transactivation) | IL-17A(h) --> Ccl2(m) (transactivation) | IL-17A(h) --> Beta-defensin2(h) (increase of secretion) | IL-17A(h) --> Defb3(m) (transactivation) | IL-17A(h) --> CCL20(h) (transactivation) | IL-17A(h) --> Ccl20(m) (transactivation) | IL-17A(h) --> MIP-3alpha(h) (increase of secretion) | IL-17A(h) --> p38(h){pT}{pY} (increase of phosphorylation) | IL-17A(h) --> eotaxin-1(h) (increase of secretion) | IL-17A(h) --> CCL11(h) (transactivation) | IL-17A(h) --> JNK(h){pT}{pY} (increase of phosphorylation) | IL17A(h) --> IL-17A(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
68 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
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Methylation Profile [Top] | ||
There is no record for IL17A | ||