Entrez Gene

Basic Information
Gene ID	5499
Name	PPP1CA
Synonymous	PP-1A\|PP1A\|PP1alpha\|PPP1A;protein phosphatase 1, catalytic subunit, alpha isozyme;PPP1CA;protein phosphatase 1, catalytic subunit, alpha isozyme
Definition	protein phosphatase 1, catalytic subunit, alpha isoform\|serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit\|serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Position	11q13
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
pRb(h) + PP1-alpha2(h) <==> pRb(h):PP1-alpha2(h) (binding)
PPP1CA(h) --> PP1-alpha2(h) (expression).
pRb(h) + PP1-alpha1(h) <==> pRb(h):PP1-alpha1(h) (binding)
neurabin-II(r) + PP1-alpha1(h) <==> neurabin-II(r):PP1-alpha1(h) (binding)
PPP1CA(h) --> PP1-alpha1(h) (expression).
KPI-2(h) + PP1-alpha(h) <==> KPI-2(h):PP1-alpha(h) (binding)
Aurora-B(h) + PP1-alpha(h) <==> Aurora-B(h):PP1-alpha(h) (binding)
PP1G(rb) + PP1-alpha(h) <==> PP1G(rb):PP1-alpha(h) (binding)
PPP1CA(h) --> PP1-alpha(h) (expression).
brca1(h){pS1423}{p}n --PP1-alpha(h)--> brca1(h){p}n + ATP (dephosphorylation)

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
320	Phosphothreonine (CDK1;CDK2;CD)	97225924;10880350;12202491	Phospho.ELM 6.0