| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 56616 |
Name | DIABLO |
Synonymous | DFNA64|SMAC;diablo, IAP-binding mitochondrial protein;DIABLO;diablo, IAP-binding mitochondrial protein |
Definition | diablo homolog, mitochondrial|direct IAP-binding protein with low pI|second mitochondria-derived activator of caspase |
Position | 12q24.31 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
Smac(h) + cIAP-1(h) <==> Smac(h):cIAP-1(h) (binding) | Smac(h) + cIAP-2(h) <==> Smac(h):cIAP-2(h) (binding) | Smac(h) + XIAP(h) <==> Smac(h):XIAP(h) (binding) | Smac(h) + survivin(h) <==> Smac(h):survivin(h) (binding) | Smac(h) + ML-IAP(h) <==> Smac(h):ML-IAP(h) (binding) | Smac(h) + ML-IAP1(h) <==> Smac(h):ML-IAP1(h) (binding) | Smac(h) + ML-IAP2(h) <==> Smac(h):ML-IAP2(h) (binding) | Smac(h) + NADE(m) <==> Smac(h):NADE(m) (binding) | Smac(h) + n ubiquitin(v.s.) --XIAP(h)--> Smac(h){ub(n)} (ubiquitination) | Smac(h) --> Smac(h) (translocation) | XIAP(h) + Smac(h) <==> XIAP(h):Smac(h) (binding) | Smac(h) --> Caspase-9-p35(h) (increase of processing) | apollon(h) + Smac(h) <==> apollon(h):Smac(h) (binding) | Smac(h) + apollon(m) <==> Smac(h):apollon(m) (binding) | Smac(h) + ubiquitin(h) --apollon(m),E1(h)--> Smac(h){ub} (ubiquitination) | Smac(h) --> Caspase-3(h):apollon(m) (decrease of binding) | Smac(h) --> Caspase-9(h):apollon(m) (decrease of binding) | XIAP(m.s.) + Smac(h) <==> XIAP(m.s.):Smac(h) (binding) | Smac(h) --> Caspase-7(h):apollon(m) (decrease of binding) | DIABLO(h) --> Smac(h) (expression). | Smac(h) --> Smac(h) (translocation) | p75NTR(m.s.) --> Smac(h) (increase of abundance) | Smac-alpha(h) + XIAP(h) <==> Smac-alpha(h):XIAP(h) (binding) | Smac-alpha(h) + XIAP(m.s.) <==> Smac-alpha(h):XIAP(m.s.) (binding) | DIABLO(h) --> Smac-alpha(h) (expression). | Caspase-7(h) + n ubiquitin(h) --XIAP(h)--> Caspase-7(h){ub(n)} (ubiquitination) | cIAP-2(h) + n ubiquitin(h) --> cIAP-2(h){ub(n)} (ubiquitination) | DIABLO(h) --> Smac-beta(h) (expression). | Smac-delta(h) + XIAP(h) <==> Smac-delta(h):XIAP(h) (binding) | Smac-delta(h) --> Smac-delta(h) (translocation) | Smac-delta(h) + XIAP(m.s.) <==> Smac-delta(h):XIAP(m.s.) (binding) | Smac-delta(h) --/ XIAP(m.s.) (decrease of abundance) | Smac-delta(h) --> XIAP(m.s.) (increase of cleavage) | Smac-delta(h) --> XIAP(m.s.){ub}n (increase of ubiquitination) | Smac-delta(h) --/ XIAP(m) (decrease of abundance) | Smac-delta(h) --> XIAP(m.s.):Caspase-9-p35(h) (decrease of binding) | Smac-delta(h) --> XIAP(m.s.):Caspase-9-p12(h) (decrease of binding) | Smac-delta(h) --> proCaspase-3(h) (increase of processing) | DIABLO(h) --> Smac-delta(h) (expression). | Smac-delta(h) --> Smac-delta(h) (translocation) | Caspase-7(h) + n ubiquitin(h) --XIAP(h)--> Caspase-7(h){ub(n)} (ubiquitination) | cIAP-2(h) + n ubiquitin(h) --> cIAP-2(h){ub(n)} (ubiquitination) |
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Post Transcriptional Modification [Top] | |||
There is no record for DIABLO | |||
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr12 |
Promoter: 121276052 - 121278052 | Agilent_014791 |
chr12 |
Promoter: 121276052 - 121278052 | GSE27584 |
chr12 |
Promoter: 121276052 - 121278052 | GSE27584 |
chr12 |
Promoter: 121276052 - 121278052 | Agilent_014791_44K |
chr12 |
Promoter: 121276052 - 121278052 | PMID:16192589 |
chr12 |
Promoter: 121276052 - 121278052 | PMID:16192589 |
chr12 |
Promoter: 121276052 - 121278052 | PMID:16192589 |