| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5727 |
Name | PTCH1 |
Synonymous | BCNS|HPE7|NBCCS|PTC|PTC1|PTCH|PTCH11;patched 1;PTCH1;patched 1 |
Definition | PTCH protein +12b|PTCH protein +4'|PTCH protein -10|PTCH protein -3,4,5|protein patched homolog 1 |
Position | 9q22.3 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
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Regulation From TransFac database |
Ptc1(h) + SMOH(m.s.) <==> Ptc1(h):SMOH(m.s.) (binding) | Ptc2(h) + Ptc1(h) <==> Ptc2(h):Ptc1(h) (binding) | Ptc1(h) + caveolin-1(m.s.) <==> Ptc1(h):caveolin-1(m.s.) (binding) | cyclinB1(h) + Ptc1(h) <==> cyclinB1(h):Ptc1(h) (binding) | Cdk1(h) + Ptc1(h) <==> Cdk1(h):Ptc1(h) (binding) | Ptc1(h) + cyclinB1(h){p} <==> Ptc1(h):cyclinB1(h){p} (regulation of localization; binding) | PTCH1(h) --> Ptc1(h) (expression). | c-Jun(m.s.) --> Ptc1(h) (decrease of promoter activity) | JunB(m.s.) --> Ptc1(h) (decrease of promoter activity) | JunD(m.s.) --> Ptc1(h) (decrease of promoter activity) | Fra-1(m.s.) --> Ptc1(h) (increase of promoter activity) | Fra-2(m.s.) --> Ptc1(h) (increase of promoter activity) | c-Fos(m.s.) --> Ptc1(h) (decrease of promoter activity) | PTCH1(h) --> Ptc1(h) (expression). | PTCH1(h) --> PTCH-Lprim(h) (expression). | PTCH1(h) --> PTCH-M(h) (expression). | PTCH1(h) --> PTCH-S(h) (expression). |
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Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
141 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 312 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 349 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 414 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 875 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1000 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr9 |
Promoter: 97310152 - 97312152 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 97310152 - 97312152 | GSE27584 |
chr9 |
Promoter: 97310152 - 97312152 | PMID:21206974 |