Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5727

Name

PTCH1

Synonymous

BCNS|HPE7|NBCCS|PTC|PTC1|PTCH|PTCH11;patched 1;PTCH1;patched 1

Definition

PTCH protein +12b|PTCH protein +4'|PTCH protein -10|PTCH protein -3,4,5|protein patched homolog 1

Position

9q22.3

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

Ptc1(h) + SMOH(m.s.) <==> Ptc1(h):SMOH(m.s.) (binding)
Ptc2(h) + Ptc1(h) <==> Ptc2(h):Ptc1(h) (binding)
Ptc1(h) + caveolin-1(m.s.) <==> Ptc1(h):caveolin-1(m.s.) (binding)
cyclinB1(h) + Ptc1(h) <==> cyclinB1(h):Ptc1(h) (binding)
Cdk1(h) + Ptc1(h) <==> Cdk1(h):Ptc1(h) (binding)
Ptc1(h) + cyclinB1(h){p} <==> Ptc1(h):cyclinB1(h){p} (regulation of localization; binding)
PTCH1(h) --> Ptc1(h) (expression).
c-Jun(m.s.) --> Ptc1(h) (decrease of promoter activity)
JunB(m.s.) --> Ptc1(h) (decrease of promoter activity)
JunD(m.s.) --> Ptc1(h) (decrease of promoter activity)
Fra-1(m.s.) --> Ptc1(h) (increase of promoter activity)
Fra-2(m.s.) --> Ptc1(h) (increase of promoter activity)
c-Fos(m.s.) --> Ptc1(h) (decrease of promoter activity)
PTCH1(h) --> Ptc1(h) (expression).
PTCH1(h) --> PTCH-Lprim(h) (expression).
PTCH1(h) --> PTCH-M(h) (expression).
PTCH1(h) --> PTCH-S(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

141N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
312N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
349N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
414N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
875N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1000N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr9

Promoter: 97310152 - 97312152GoldenGate_Methylation_Cancer_Panel_I

chr9

Promoter: 97310152 - 97312152GSE27584

chr9

Promoter: 97310152 - 97312152PMID:21206974


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