Entrez Gene

Basic Information
Gene ID	5728
Name	PTEN
Synonymous	10q23del\|BZS\|CWS1\|DEC\|GLM2\|MHAM\|MMAC1\|PTEN1\|TEP1;phosphatase and tensin homolog;PTEN;phosphatase and tensin homolog
Definition	MMAC1 phosphatase and tensin homolog deleted on chromosome 10\|mitochondrial PTENalpha\|mitochondrial phosphatase and tensin protein alpha\|mutated in multiple advanced cancers 1\|phosphatase and tensin-like protein\|phosphatidylinositol 3,4,5-trisphosphate 3-
Position	10q23.3
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Experimentally validated miRNA-TS gene regulation information.

Regulation From TransFac database
Transcription Factors [Top]
MVP(h) + PTEN(h) <==> MVP(h):PTEN(h) (binding)
PTEN(h) + 2 ATP --CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2--> PTEN(h){pS370}{pS385} + 2 ADP (phosphorylation)
CKII-alpha(h) + PTEN(h) <==> CKII-alpha(h):PTEN(h) (binding)
PTEN(h) + 5 ATP --CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2--> PTEN(h){pS370}{pS380}{pT382}{pT383}{pS385} + 5 ADP (phosphorylation)
PTEN(h) + 5 ATP --CKII(mo)--> PTEN(h){pS370}{pS380}{pT382}{pT383}{pS385} + 5 ADP (phosphorylation)
p300(h) + PTEN(h) <==> p300(h):PTEN(h) (binding)
p53(h) + PTEN(h) <==> p53(h):PTEN(h) (binding)
PTEN(h) + 3 ATP --> PTEN(h){pS380}{pT381}{pT382} + 3 ADP (phosphorylation)
PTEN(h) + ubiquitin(h) --> PTEN(h){ub} (ubiquitination)
PTEN(h) --> AKT-1(h){pT308}{pS473} (decrease of phosphorylation)
PTEN(h) --> p21Cip1(h) (increase of abundance)
PTEN(h) --/ Skp2(h) (decrease of abundance)
PTEN(h) --> AKT-1(h){pS473} (decrease of phosphorylation)
HAUSP(h) + PTEN(h) <==> HAUSP(h):PTEN(h) (binding)
PTEN(h) + HAUSP(m.s.) <==> PTEN(h):HAUSP(m.s.) (binding)
PTEN(h) --> PTEN(h) (expression).
estradiol --/ PTEN(h) (decrease of abundance)
p53(h) --> PTEN(h) (increase of abundance)
p53(m.s.) --> PTEN(h) (increase of abundance)
mdm2(m.s.) --/ PTEN(h) (decrease of abundance)
p16INK4a(m.s.) --> PTEN(h) (increase of abundance)
estradiol --> PTEN(h) (increase of abundance)
Fzr(h) --/ PTEN(h) (decrease of abundance)
PTEN(h){ub} --HAUSP(m.s.)--> PTEN(h) + ubiquitin(h) (deubiquitination)
PIP3 --PTEN(h)--> PIP2 + p (dephosphorylation)
PtdIns(3,4)P2 --PTEN(h)--> PtdIns(4)P + p (dephosphorylation)
PtdIns(3)P --PTEN(h)--> PtdIns + p (dephosphorylation)
Ins(1,3,4,5)P4 --PTEN(h)--> IP3 + p (dephosphorylation)
PTEN(h) --> p38(m.s.){p} (decrease of phosphorylation)
PTEN(h) --> PTEN(h) (expression).
PTEN(h) --> PTEN(h) (expression).
hsa-miR-19a --/ PTEN(h) (predicted)
hsa-miR-19b --/ PTEN(h) (predicted)
hsa-miR-214 --/ PTEN(h) (translational repression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
366	Phosphothreonine.		Swiss-Prot 53.0
370	Phosphoserine (by CK2).		Swiss-Prot 53.0
385	Phosphoserine (by CK2).		Swiss-Prot 53.0
401	Phosphothreonine.		Swiss-Prot 53.0
383	Phosphothreonine	10866658	Phospho.ELM 6.0
380	Phosphoserine (CK2 alpha;PK)	12077256;10866658;11035045	Phospho.ELM 6.0
382	Phosphothreonine (CK2 alpha)	10866658;11035045	Phospho.ELM 6.0
240	Phosphotyrosine (Lck)	11948419	Phospho.ELM 6.0
315	Phosphotyrosine (Lck)	11948419	Phospho.ELM 6.0
229	Phosphoserine (ROCK1)	15793569	Phospho.ELM 6.0
232	Phosphothreonine (ROCK1)	15793569	Phospho.ELM 6.0
362	Phosphoserine (GSK-3beta)	16107342	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr10	Promoter: 89611675 - 89613675	Agilent_014791
chr10	Promoter: 89611675 - 89613675	GoldenGate_Methylation_Cancer_Panel_I
chr10	Promoter: 89611675 - 89613675	GSE27584
chr10	Promoter: 89611675 - 89613675	Agilent_014791
chr10	Promoter: 89611675 - 89613675	PMID:16889486
chr10	Promoter: 89611675 - 89613675	PMID:15196854
chr10	Promoter: 89611675 - 89613675	PMID:16928264
chr10	Promoter: 89611675 - 89613675	PMID:15198948
chr10	Promoter: 89611675 - 89613675	PMID:16192589
chr10	Promoter: 89611675 - 89613675	PMID:17177027
chr10	Promoter: 89611675 - 89613675	PMID:15389252
chr10	Promoter: 89611675 - 89613675	PMID:15126336
chr10	Promoter: 89611675 - 89613675	PMID:16818626
chr10	Promoter: 89611675 - 89613675	PMID:15596045
chr10	Promoter: 89611675 - 89613675	PMID:16258501
chr10	Promoter: 89611675 - 89613675	PMID:15891996
chr10	Promoter: 89611675 - 89613675	PMID:11896207
chr10	Promoter: 89611675 - 89613675	PMID:15382065
chr10	Promoter: 89611675 - 89613675	PMID:15662588
chr10	Promoter: 89611675 - 89613675	PMID:12660822
chr10	Promoter: 89611675 - 89613675	PMID:16739377
chr10	Promoter: 89611675 - 89613675	PMID:15975525
chr10	Promoter: 89611675 - 89613675	PMID:16983315
chr10	Promoter: 89611675 - 89613675	PMID:12006535
chr10	Promoter: 89611675 - 89613675	PMID:15547698

Experimentally verified miRNA from miRTarBase [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]