Entrez Gene

Basic Information
Gene ID	641
Name	BLM
Synonymous	BS\|RECQ2\|RECQL2\|RECQL3;Bloom syndrome, RecQ helicase-like;BLM;Bloom syndrome, RecQ helicase-like
Definition	Bloom syndrome protein\|DNA helicase, RecQ-like type 2\|recQ protein-like 3
Position	15q26.1
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
BLM(h) --> BLMp47(h) + BLMp112(h) (cleavage)
BLM(h) --Caspase-3(h)--> BLMp112(h) + BLMp47(h) (cleavage)
FEN1(h) + BLM(h) <==> FEN1(h):BLM(h) (binding)
BLM(h) + 53BP1(h) <==> BLM(h):53BP1(h) (binding)
BLM(h) + Chk1(h) <==> BLM(h):Chk1(h) (binding)
BLM(h) + ATP --Chk1(h)--> BLM(h){pS} + ADP (phosphorylation)
53BP1(h) + BLM(h) + p53(h) <==> 53BP1(h):BLM(h):p53(h) (binding)
GTBP(h) + BLM(h) <==> GTBP(h):BLM(h) (binding)
BLM(h) + MSH2(h) <==> BLM(h):MSH2(h) (binding)
Rad51(h) + BLM(h) <==> Rad51(h):BLM(h) (binding)
BLM(h) + Ubc9(h) <==> BLM(h):Ubc9(h) (binding)
BLM(h) + sumo1(h) --> BLM(h){sumo} (sumoylation)
BLM(h) + SUMO2(h) --> BLM(h){sumo2} (sumoylation)
RFC4(h) + RFC2(h) + MLH1(h) + MSH2(h) + RECC1(h) + BLM(h) + ATM(h) + brca1(h) + GTBP(h) <==> RFC4(h):RFC2(h):MLH1(h):MSH2(h):RECC1(h):BLM(h):ATM(h):brca1(h):GTBP(h) (binding)
BLM(h) + brca1(h) <==> BLM(h):brca1(h) (binding)
BLM(h) + ATM(h) <==> BLM(h):ATM(h) (binding)
BLM(h) + MLH1(h) <==> BLM(h):MLH1(h) (binding)
RECC1(h) + BLM(h) <==> RECC1(h):BLM(h) (binding)
Rad50(h) + BLM(h) <==> Rad50(h):BLM(h) (binding)
BLM(h) + NBS1(h) <==> BLM(h):NBS1(h) (binding)
BLM(h) + Rad50(h) + MSH2(h) + ATM(h) + brca1(h) + RECC1(h) <==> BLM(h):Rad50(h):MSH2(h):ATM(h):brca1(h):RECC1(h) (binding)
BLM(h) --> BLM(h) (expression).
FEN1(h) + BLM(h) <==> FEN1(h):BLM(h) (binding)
BLM(h) --> BLM(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
419	Phosphoserine.		Swiss-Prot 53.0
422	Phosphoserine.		Swiss-Prot 53.0
499	Phosphoserine.		Swiss-Prot 53.0
508	Phosphothreonine.		Swiss-Prot 53.0
1296	Phosphoserine.		Swiss-Prot 53.0
1296	Phosphoserine	15302935	Phospho.ELM 6.0
99	Phosphothreonine (ATM)	11375976	Phospho.ELM 6.0
122	Phosphothreonine	14729972	Phospho.ELM 6.0
419	Phosphoserine	16565220	Phospho.ELM 6.0
422	Phosphoserine	16565220	Phospho.ELM 6.0