Entrez Gene

Basic Information
Gene ID	64326
Name	RFWD2
Synonymous	COP1\|RNF200;ring finger and WD repeat domain 2, E3 ubiquitin protein ligase;RFWD2;ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
Definition	E3 ubiquitin-protein ligase RFWD2\|RING finger protein 200\|constitutive photomorphogenesis protein 1 homolog\|putative ubiquitin ligase COP1
Position	1q25.1-q25.2
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
COP1(h) + DET1(h) <==> COP1(h):DET1(h) (binding)
DDB1(m) + COP1(h) <==> DDB1(m):COP1(h) (binding)
c-Jun(h) + COP1(h) <==> c-Jun(h):COP1(h) (binding)
p53(h) + COP1(h) <==> p53(h):COP1(h) (binding)
COP1(h) + Roc1(h) <==> COP1(h):Roc1(h) (binding)
COP1(h) --/ p21Cip1(h) (decrease of abundance)
COP1(h) --/ p53(h) (decrease of abundance)
RFWD2(h) --> COP1(h) (expression).
c-Jun(h) + n ubiquitin(h) --COP1(h),DET1(h)--> c-Jun(h){ub(n)} (ubiquitination)
c-Jun(h) + n ubiquitin(v.s.) --E1(rb),Ubc5C(h),DET1(h),DDB1(h),CUL4A(m),Roc1(h),COP1(h),ATP--> c-Jun(h){ub(n)} (ubiquitination)
p53(h) + n ubiquitin(v.s.) --COP1(h)--> p53(h){ub(n)} (ubiquitination)
p53(h) + n ubiquitin(v.s.) --E1(rb),Ubc5A(h),COP1(h)--> p53(h){ub(n)} (ubiquitination)
RFWD2(h) --> COP1-isoform1(h) (expression).
RFWD2(h) --> COP1-isoform2(h) (expression).
RFWD2(h) --> COP1-isoform3(h) (expression).

Post Transcriptional Modification [Top]
	There is no record for RFWD2