Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6772

Name

STAT1

Synonymous

CANDF7|IMD31A|IMD31B|IMD31C|ISGF-3|STAT91;signal transducer and activator of transcription 1, 91kDa;STAT1;signal transducer and activator of transcription 1, 91kDa

Definition

signal transducer and activator of transcription 1, 91kD|signal transducer and activator of transcription 1-alpha/beta|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84

Position

2q32.2

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

STAT1beta(h) --> IRF1(h) (DNA binding).
STAT1alpha(h) + STAT1beta(h) <==> STAT1alpha(h):STAT1beta(h) (binding).
STAT1beta(h) + STAT2(h) <==> STAT1beta(h):STAT2(h) (binding)
STAT1alpha(m) + STAT1beta(h) <==> STAT1beta(h):STAT1alpha(m) (binding).
STAT1beta(h) --> CCL2(h) (DNA binding; transactivation).
STAT1beta(h) --> protein remnants (degradation)
brca1(h) + STAT1beta(h) <==> brca1(h):STAT1beta(h) (binding)
STAT1beta(h) + RON(h) <==> STAT1beta(h):RON(h) (binding)
ErbB1(h) + STAT1beta(h) <==> ErbB1(h):STAT1beta(h) (binding)
STAT1beta(h) + ATP --> STAT1beta(h){pY} + ADP (phosphorylation)
STAT1beta(h) + CaMKII-gamma(h) <==> STAT1beta(h):CaMKII-gamma(h) (binding)
STAT1beta(h) --> Cxcl9(m) (DNA binding).
STAT1beta(h) + ATP --> STAT1beta(h){pY701} + ADP (phosphorylation)
STAT1(h) --> STAT1beta(h) (expression).
IFNgamma(m.s.) --> STAT1beta(h) (increase of abundance)
IFNbeta(h) --> STAT1beta(h) (increase of abundance)
PDGFRbeta(h) + STAT1alpha(h) <==> PDGFRbeta(h):STAT1alpha(h) (binding)
STAT1alpha(h) --> IRF1(h) (DNA binding; transactivation).
c-Kit(h) + STAT1alpha(h) <==> c-Kit(h):STAT1alpha(h) (binding)
STAT1alpha(h) + ATP --c-Kit(h)--> STAT1alpha(h){pY} + ADP (phosphorylation)
STAT1alpha(m) + STAT1alpha(h) <==> STAT1alpha(m):STAT1alpha(h) (binding).
STAT1alpha(h) + STAT2(h) <==> STAT1alpha(h):STAT2(h) (binding)
STAT1alpha(h) + STAT1beta(h) <==> STAT1alpha(h):STAT1beta(h) (binding).
STAT1alpha(h) + ATP --> STAT1alpha(h){pS727} + ADP (phosphorylation)
STAT1alpha(h) + STAT1alpha(h) <==> STAT1alpha(h):STAT1alpha(h) (binding).
STAT1alpha(h) --> CYBB(h) (DNA binding; transactivation).
STAT1alpha(h) + NTP --Bmx(m)--> STAT1alpha(h){pY} + NDP (phosphorylation)
STAT1alpha(h) + NTP --Jak2(m)--> STAT1alpha(h){pY} + NDP (phosphorylation)
STAT1alpha(h) --> CCL2(h) (DNA binding; transactivation).
STAT1alpha(h) --> Irf1(r) (DNA binding; transactivation).
STAT1alpha(h) + ATP --> STAT1alpha(h){pY} + ADP (phosphorylation)
STAT1alpha(h) --> protein remnants (degradation)
brca1(h) + STAT1alpha(h) <==> brca1(h):STAT1alpha(h) (binding)
STAT1alpha(h) + brca1(h) <==> STAT1alpha(h):brca1(h) (binding)
STAT1alpha(h) + RON(h) <==> STAT1alpha(h):RON(h) (binding)
ErbB1(h) + STAT1alpha(h) <==> ErbB1(h):STAT1alpha(h) (binding)
STAT1alpha(h) --> CD40(h) (DNA binding).
STAT1alpha(h) --> CD86(h) (DNA binding).
STAT1alpha(h) --> S100A10(h) (DNA binding).
STAT1alpha(h) --> HLA-E(h) (DNA binding).
STAT1alpha(h) --> FCGR1C(h) (DNA binding).
STAT1alpha(h) --> Tap1(h) (DNA binding).
PIAS1(m.s.) + STAT1alpha(h) <==> PIAS1(m.s.):STAT1alpha(h) (binding)
STAT1alpha(h) + 2 ATP --> STAT1alpha(h){pY701}{pS727} + 2 ADP (phosphorylation)
p300(h) + STAT1alpha(h) <==> p300(h):STAT1alpha(h) (binding)
STAT1alpha(h) + ATP --> STAT1alpha(h){pY701} + ADP (phosphorylation)
STAT1alpha(h) + CaMKII(h) <==> STAT1alpha(h):CaMKII(h) (binding)
STAT1alpha(h) + CaMKII-gamma(h) <==> STAT1alpha(h):CaMKII-gamma(h) (binding)
STAT1alpha(h) + ATP --CaMKII(h)--> STAT1alpha(h){pS727} + ADP (phosphorylation)
STAT1alpha(h) --> Cxcl9(m) (DNA binding).
STAT1alpha(h) --> PRF1(h) (DNA binding).
STAT1alpha(h) + IFNGR(h){pY457} <==> STAT1alpha(h):IFNGR(h){pY457} (binding)
STAT1alpha(h) --> STAT1alpha(h) (translocation)
STAT1alpha(h) --> STAT1alpha(h) (translocation)
ERK2(h) + STAT1alpha(h) <==> ERK2(h):STAT1alpha(h) (binding)
STAT1(h) --> STAT1alpha(h) (expression).
IFNgamma(m.s.) --> STAT1alpha(h) (increase of abundance)
IFNbeta(h) --> STAT1alpha(h) (increase of abundance)
STAT1alpha(h) --> STAT1alpha(h) (translocation)
STAT1alpha(h) --> STAT1alpha(h) (translocation)
IFNbeta(h) --> STAT1alpha(h) (increase of abundance)
STAT1(h) --> IL-2Ralpha(m) (DNA binding).
STAT1(h) --> IL-2Ralpha(h) (DNA binding).
STAT1(h) --> A2-Mag(r) (DNA binding).
STAT1(h) --> FOS(h) (DNA binding; transactivation).
STAT1(h) --> FCGR1A(h) (DNA binding).
STAT1(h) --> CDKN1A(h) (DNA binding; transactivation).
STAT1(h) --Caspase-3(h)--> protein remnants (processing)
STAT1(h) + ATP --p38alpha(h)--> STAT1(h){pS727} + ADP (phosphorylation)
STAT1(h) + ATP --p38beta2(h)--> STAT1(h){pS727} + ADP (phosphorylation)
STAT1(h) + ATP --protein tyrosine kinases(v.s.)--> STAT1(h){pY701} + ADP (phosphorylation)
STAT1(h) + ATP --Jak2(r)--> STAT1(h){pY} + ADP (phosphorylation)
RACK1(h) + STAT1(h) <==> RACK1(h):STAT1(h) (binding)
STAT1(h) --> CIITA(h) (DNA binding; transactivation).
2 STAT1(h) <==> STAT1(h):STAT1(h) (binding)
STAT1(h) + STAT3(h) <==> STAT1(h):STAT3(h) (binding)
STAT1(h) + ATP --Jak2(m)--> STAT1(h){p} + ADP (phosphorylation)
Fes(h) + STAT1(h) <==> Fes(h):STAT1(h) (binding)
STAT1(h) --> c-myc(h) (DNA binding; transactivation).
RelA-p65(h) + STAT1(h) + CBP(m) <==> STAT1(h):RelA-p65(h):CBP(m) (assembly; binding; interaction)
STAT1(h) --> Cxcl9(m) (DNA binding; transactivation).
ErbB1(h) + STAT1(h) <==> ErbB1(h):STAT1(h) (binding)
Src(h) + STAT1(h) <==> Src(h):STAT1(h) (binding)
STAT1(h) --> CCND1(h) (DNA binding; transactivation).
STAT1(h) --> TRH(h) (DNA binding; transactivation).
STAT1(h) --> IRF1(h) (DNA binding; transactivation).
STAT1(h) --> PIM1(h) (DNA binding; transactivation).
STAT1(h) --> IFP 53(h) (DNA binding; transactivation).
STAT1(h) --> SOAT1(h) (DNA binding; transactivation).
uPAR(h) + STAT1(h) <==> uPAR(h):STAT1(h) (binding)
STAT1(h) + ATP --> STAT1(h){p} + ADP (phosphorylation)
STAT1(h) + c-Jun(h) <==> STAT1(h):c-Jun(h) (binding) [re.
STAT1(h) + sumo1(m.s.) --> STAT1(h){sumo} (sumoylation)
STAT1(h) + sumo1(h) --> STAT1(h){sumo} (sumoylation)
HSF1(h) + STAT1(h) <==> HSF1(h):STAT1(h) (binding)
Chk2(h) + STAT1(h) <==> Chk2(h):STAT1(h) (binding)
NFBD1(h) + STAT1(h) <==> NFBD1(h):STAT1(h) (binding)
53BP1(h) + STAT1(h) <==> 53BP1(h):STAT1(h) (binding)
STAT1(h) --> ATM(h){pS1981} (increase of abundance)
GRP58(h) + Hsp90(h) + STAT1(h) + caveolin-1(h) + STAT3(h) <==> GRP58(h):Hsp90(h):STAT1(h):caveolin-1(h):STAT3(h) (binding)
STAT1(h) --> STAT1(h) (translocation)
irf1(h) + STAT1(h) <==> irf1(h):STAT1(h) (binding)
STAT1(h) --> Mt1(m) (DNA binding).
STAT1(h) --> OPRM1(h) (DNA binding).
STAT1(h) --> PSMB9(h) (DNA binding).
STAT1(h) + ATP --> STAT1(h){pY701} + ADP (phosphorylation)
ErbB1-p170(h){pY998}{pY1016} + STAT1(h) <==> ErbB1-p170(h){pY998}{pY1016}:STAT1(h) (binding)
ErbB2(h){pY1221}{pY1222} + STAT1(h) <==> ErbB2(h){pY1221}{pY1222}:STAT1(h) (binding)
ErbB3-isoform1(h){pY1262} + STAT1(h) <==> ErbB3-isoform1(h){pY1262}:STAT1(h) (binding)
ErbB4(h) + STAT1(h) <==> ErbB4(h):STAT1(h) (binding)
HCV-core(HCV) + STAT1(h) <==> HCV-core(HCV):STAT1(h) (binding)
STAT2(h) + STAT1(h) <==> STAT2(h):STAT1(h) (binding)
HCV-NS5A-1B-Japanese(HCV1BJapan) + STAT1(h) <==> HCV-NS5A-1B-Japanese(HCV1BJapan):STAT1(h) (binding)
STAT1(h) --> VIP(h) (DNA binding).
STAT1(h) --> GLOB-AG(h) (DNA binding).
STAT1(h) --> NOS2(h) (DNA binding; transactivation).
STAT1(h) --> MUC1(h) (DNA binding; transactivation).
STAT1(h) --> IL6ST(h) (DNA binding; transactivation).
STAT1(h) --> Tcfap2a(m) (DNA binding).
Jak1(h) + STAT1(h) <==> Jak1(h):STAT1(h) (binding)
STAT1(h) + ATP --> STAT1(h){pY} + ADP (phosphorylation)
STAT1(h) + STAT2(h) <==> STAT2(h):STAT1(h) (binding)
STAT1(h) + LPLUNC3(h) <==> STAT1(h):LPLUNC3(h) (binding)
RBTN2(h) + STAT1(h) <==> RBTN2(h):STAT1(h) (binding)
STAT1(h) + eif1ad(h) <==> STAT1(h):eif1ad(h) (binding)
STAT1(h) --> CCL19(h) (DNA binding).
STAT1(h) + STAT5(h) <==> STAT1(h):STAT5(h) (binding)
STAT1(h) --> Ly6a(m) (DNA binding).
STAT1(h) --> ICAM1(h) (DNA binding).
STAT1(h) --> INDO(h) (DNA binding).
STAT1(h) --> IFNG(h) (DNA binding).
STAT1(h) --> CD86(h) (DNA binding).
STAT1(h) --> MYD88(h) (DNA binding).
STAT1(h) --> IL21(h) (DNA binding).
STAT1(h) --> AGT(h) (DNA binding).
STAT1(h) --> FCER2(h) (DNA binding).
STAT1(h) --> Klf4(m) (DNA binding).
STAT1(h) --> NOX1(h) (DNA binding).
STAT1(h) --> MVP(h) (DNA binding).
STAT1(h) --> Tap1(h) (DNA binding).
STAT1(h) --> BIRC4BP(h) (DNA binding).
STAT1(h) --> Irf1(m) (DNA binding).
STAT1(h) --> FCGR1C(h) (DNA binding).
STAT1(h) + 2 ATP --> STAT1(h){pY701}{pS727} + 2 ADP (phosphorylation)
STAT1(h) + ATP --> STAT1(h){pS727} + ADP (phosphorylation)
STAT1(h) --> BACE1(h) (transactivation)
STAT1(h) --> Asp2(h) (increase of abundance)
STAT1(h) + PKCdelta(h) <==> STAT1(h):PKCdelta(h) (binding)
STAT1(h) + Src(h){pY} <==> STAT1(h):Src(h){pY} (binding)
Jak2(h) + STAT1(h) <==> Jak2(h):STAT1(h) (binding)
STAT1(h) + Jak1(h){pY} <==> STAT1(h):Jak1(h){pY} (binding)
STAT1(h) + Jak2(h){pY} <==> STAT1(h):Jak2(h){pY} (binding)
STAT1(h) --> c-myc(m) (DNA binding).
STAT1(h) --> IL1B(h) (DNA binding).
STAT1(h) --> MSR1(h) (DNA binding).
STAT1(h) --> IVL(h) (DNA binding).
STAT1(h) --> FCGRT(h) (DNA binding).
STAT1(h) + ATP --PKCdelta(h)--> STAT1(h){pS727} + ADP (phosphorylation)
STAT1(h) --> S100P(h) (DNA binding).
IL-22(h) --> STAT1(h) (activation; phosphorylation)
IL-17A(h) --> STAT1(h) (activation; phosphorylation)
AT2(h) --> STAT1(h) (activation)
STAT1(h) --> STAT1(h) (expression).
p53(h) --/ STAT1(h) (decrease of abundance)
STAT1(h) --> STAT1(h) (translocation)
HCV-NS4A(HCV):HCV-NS3(HCV) --/ STAT1(h) (decrease of abundance)
HCV-E1(HCV) --/ STAT1(h) (decrease of abundance)
HCV-E2(HCV) --/ STAT1(h) (decrease of abundance)
IFNgamma(m.s.) --> STAT1(h) (increase of abundance)
IFNbeta(h) --> STAT1(h) (increase of abundance)
IFNgamma(h) --> STAT1(h) (increase of abundance)
IFNalpha(m.s.) --> STAT1(h) (increase of abundance)
STAT1(h){pY701} --TC-PTP(h)--> STAT1(h) + p (dephosphorylation)
IFN-lambda(m.s.) --> STAT1(h) (increase of abundance)
IFNalpha(m) --> STAT1(h) (increase of abundance)
IFNbeta(m.s.) --> STAT1(h) (increase of abundance)
IFNalpha2a(h) --> STAT1(h) (increase of abundance)

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

701Phosphotyrosine (by JAK).Swiss-Prot 53.0
727Phosphoserine.Swiss-Prot 53.0
727Phosphoserine95354205Phospho.ELM 6.0
701Phosphotyrosine (Src;EGFR;JAK)7592750;15322115;11438544;10748192Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr2

Promoter: 191586681 - 191588681Agilent_014791

chr2

Promoter: 191586681 - 191588681GSE27584

chr2

Promoter: 191586681 - 191588681GSE27584

chr2

Promoter: 191586681 - 191588681Agilent_014791_44K

chr2

Promoter: 191586681 - 191588681Agilent_014791

chr2

Promoter: 191586681 - 191588681PMID:16242928

chr2

Promoter: 191586681 - 191588681PMID:16242928

chr2

Promoter: 191586681 - 191588681PMID:16449678

chr2

Promoter: 191586681 - 191588681PMID:16449678


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